Biomedical moldings

• US 6,555,103 B2
• Filed: 08/14/2001
• Issued: 04/29/2003
• Est. Priority Date: 08/14/2000
• Status: Expired due to Fees

• Current Assignee: Novartis Ag
• Original Assignee: Novartis Ag
• Inventors: Lohmann, Dieter, Chabrecek, Peter, Leukel, Jörg
• Primary Examiner(s): Dees, Jose G.
• Assistant Examiner(s): George, Konata M.
• Application Number:
  US09/929,670
• Publication Number:
  US 20020022013A1
• Time in Patent Office: 623 Days
• Field of Search: 424/78.04, 424/427, 623/5, 514/764
• US Class Current: 424/78.04
• CPC Class Codes: A61L 27/14 Macromolecular materials
• CPC Class Codes: C08L 101/02 characterised by the presence of specified groups , e.g. terminal or pendant functional groups

Abstract

The present invention is concerned with a biomedical molding comprising a non-biodegradable biocompatible organic polymer comprising attached to its surface radicals of formula

wherein the variables are as defined in the claims. The biomedical moldings of the invention are radiation sensitive and may be used, for example, as intraocular lens in ophthalmic surgery.

Claims

1. A biomedical molding comprising a non-biodegradable biocompatible organic polymer comprising attached to its surface radicals of formula

wherein R₁ is hydroxy, C₁-C₄-alkyl, C₁-C₄-alkoxy, sulfo, nitro, trifluoromethyl or halogen, m is an integer from 0 to 2, and Z is a group which functions as a triggerable precursor for carbene, nitrene or benzhydrol formation.

2. A biomedical molding according to claim 1, wherein the biocompatible organic polymer is selected from a polyurethane, epoxy resin, polyether, polyester, polyamide, polyimide, polyolefine, polybutadiene, polyisoprene and a silicone.

3. A biomedical molding according to claim 1, wherein the biocompatible organic polymer is selected from a polysiloxane, perfluoroalkyl polyether, fluorinated poly(meth)acrylate, polyalkyl (meth)acrylate, polyolefine and a fluorinated polyolefine.

4. A biomedical molding according to claim 1, wherein Z in formula (1) is a group of formula

wherein R₃ is fluorinated C₁-C₆-alkyl, R₁′

is hydroxy, C₁-C₄-alkyl, C₁-C₄-alkoxy, sulfo, nitro, trifluoromethyl or halogen, and m1 is 0 or 1.

5. A biomedical molding according to claim 1, comprising attached to its surface radicals of formula

wherein R₁, m and Z are defined as in claim 1, and A is a functional group of formula

6. A biomedical molding according to claim 1, comprising attached to its surface radicals of formula

wherein R₁, m and Z are each as defined in claim 1, and A′

is a spacer group of formula

7. A biomedical molding according to claim 1, wherein the radicals of formula (1) are attached to the molding surface by a process comprising the steps of

(i) providing the molding surface with reactive groups by a plasma induced polymerization of an ethylenically unsaturated compound carrying a reactive group;

and

(ii) reacting the reactive groups of the modified molding surface with a coreactive compound comprising a radical of formula (1).

8. A biomedical molding according to claim 1, which is a corneal onlay.

9. A process for implanting a corneal onlay onto a cornea comprising the steps of

(i) providing an onlay comprising groups of formula (1) according to claim 1 at its anterior surface only;

(ii) placing the onlay in contact with the corneal tissue; and

(iii) irradiating the onlay whereby the onlay is fixed on the cornea.

10. A process for implanting a corneal onlay onto a cornea comprising the steps of

(i) providing an onlay comprising groups of formula (1) according to claim 1 at both its posterior and anterior surface,

(ii) placing the onlay in contact with the corneal tissue,

(iii) before or after step (ii) coating the posterior surface with one or more components which promote the growth of tissue adjacent to the implanted onlay;

and

(iv) irradiating the onlay whereby the onlay is fixed on the cornea, and the tissue growth promoting compound is fixed on the posterior onlay surface.

11. A process according to claim 10, wherein the tissue growth promoting compound is an albumine, extracellular matrix (ECM), fibronectin, laminin, chondroitan sulfate, collagen, cell-attachment protein, anti-gelatine factor, cold-insoluble globulin, chondronectin, epidermal growth factor, mussel adhesive protein, sialo protein, thrombospondin, vitronectin, proteoglycan, or a mixture of two or more of the compounds mentioned.

12. A method of using a non-biodegradable biocompatible organic polymer comprising attached to its surface radicals of formula

wherein

R₁ is an electron-withdrawing substituent, m is an integer from 0 to 2, and

Z is a group which functions as a triggerable precursor for carbene, nitrene or benzhydrol formation, as an intraocular lens for the implantation into or onto a cornea, comprising the step of attaching said organic polymer to the cornea.