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Method for determining analyte concentration using periodic temperature modulation and phase detection

  • US 6,556,850 B1
  • Filed: 09/15/2000
  • Issued: 04/29/2003
  • Est. Priority Date: 03/12/1997
  • Status: Expired due to Fees
First Claim
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1. A method of determining the absolute or relative concentration of a chemical analyte in a medium, said method comprising the steps of:

  • a) inducing at least one thermal gradient into said medium;

    b) responsive to said inducing step, measuring the radiation emitted from said medium at a predetermined wavelength related to said analyte, resulting in an analytical signal;

    c) Further responsive to said inducing step, measuring the radiation emitted from said medium at least one reference wavelength, resulting in at least one reference signal;

    d) comparing the analytical signal with at least one of said at least one reference signals;

    e) determining from said comparison, a parameter between said analytical signal and said at least one reference signal; and

    f) deducing from said parameter the concentration of said analyte in said medium.

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