Software for high throughput microfluidic systems
First Claim
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1. A computer implemented method of analyzing an array of sample compounds utilizing a microfluidic device, comprising:
- receiving a signal corresponding to sample compounds being driven through the microfluidic device;
analyzing the signal to detect a deviation from a steady state signal, wherein analyzing the signal includes determining if the signal exceeds a threshold deviation, wherein the threshold deviation is 10%; and
identifying a sample compound that caused the threshold deviation.
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Abstract
Techniques for analyzing an array of compounds utilizing a high throughput microfluidic system are provided. The system can translate a plurality of multiwell plates through various stations for analysis. Effects to sample compounds can be identified according to deviations in a steady state signal. Also, a user can enter the dwell times for sample compounds and a buffer solution so that the system will alternatingly inject the sample compounds and buffer solution into a microfluidic device according to the specified dwell times.
155 Citations
41 Claims
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1. A computer implemented method of analyzing an array of sample compounds utilizing a microfluidic device, comprising:
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receiving a signal corresponding to sample compounds being driven through the microfluidic device;
analyzing the signal to detect a deviation from a steady state signal, wherein analyzing the signal includes determining if the signal exceeds a threshold deviation, wherein the threshold deviation is 10%; and
identifying a sample compound that caused the threshold deviation.
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2. A computer implemented method of analyzing an array of sample compounds utilizing a microfluidic device, comprising:
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receiving a signal corresponding to sample compounds being driven through the microfluidic device;
analyzing the signal to detect a deviation from a steady state signal, wherein analyzing the signal includes determining if the signal exceeds a threshold deviation and wherein the expected signal profile is based on a signal from a control experiment for obtaining the expected signal profile; and
identifying a sample compound that caused the threshold deviation.
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3. A computer implemented method of analyzing an array of sample compounds utilizing a microfluidic device, comprising:
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receiving a signal corresponding to sample compounds being driven through the microfluidic device, wherein the sample compounds are stored in multiple wells in which markers are stored in known wells;
analyzing the signal to detect a deviation from a steady state signal, wherein analyzing the signal includes determining if the signal exceeds a threshold deviation; and
identifying a sample compound that caused the threshold deviation. - View Dependent Claims (4, 5)
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6. A computer implemented method of analyzing an array of sample compounds utilizing a microfluidic device, comprising:
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receiving a signal corresponding to sample compounds being driven through the microfluidic device;
analyzing the signal to detect a deviation from a steady state signal, wherein analyzing the signal includes determining if the signal exceeds a threshold deviation;
identifying a sample compound that caused the threshold deviation;
identifying sample compounds in the signal that are near in time being driven through the microfluidic device to the identified sample compound; and
directing the identified sample compounds to be driven through the microfluidic device again for analysis.
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7. A computer implemented method of analyzing an array of sample compounds utilizing a microfluidic device, comprising:
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receiving user input specifying a dwell time for the sample compounds;
receiving user input specifying a dwell time for a buffer solution;
receiving user input specifying at least one of an initial delay time before the sample compounds and buffer solution are injected into the microfluidic device and a final delay time after the sample compounds and buffer solution are injected into the microfluidic device; and
alternatingly injecting the sample compounds and buffer solution into the microfluidic device for the specified dwell times for the sample compounds and buffer solution. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A computer program product that analyzes an array of sample compounds utilizing a microfluidic device, comprising:
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computer code that receives user input specifying a dwell time for the sample compounds;
computer code that receives user input specifying a dwell time for a buffer solution;
computer code that directs the sample compounds and buffer solution to be alternatingly injected into the microfluidic device for the specified dwell times for the sample compounds and buffer solution;
computer code that receives user input specifying at least one of an initial delay time before the sample compounds and buffer solution are injected into the microfluidic device and a final delay time after the sample compounds and buffer solution are injected into the microfluidic device; and
a computer readable medium that stores the computer codes. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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36. A computer program product that analyzes an array of sample compounds utilizing a microfluidic device, comprising:
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computer code that receives a signal corresponding to sample compounds being driven through the microfluidic device;
computer code that analyzes the signal to detect a deviation from a steady state signal, wherein the computer code that analyzes the signal includes computer code that determines if the signal exceeds a threshold deviation, wherein the threshold deviation is 10%;
computer code that identifies a sample compound that caused the threshold deviation; and
a computer readable medium that stores the computer codes.
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37. A computer program product that analyzes an array of sample compounds utilizing a microfluidic device, comprising:
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computer code that receives a signal corresponding to sample compounds being driven through the microfluidic device;
computer code that analyzes the signal to detect a deviation from a steady state signal, wherein the computer code that analyzes the signal includes computer code that determines if the signal exceeds a threshold deviation and wherein the expected signal profile is based on a signal from a control experiment for obtaining the expected signal profile;
computer code that identifies a sample compound that caused the threshold deviation; and
a computer readable medium that stores the computer codes.
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38. A computer program product that analyzes an array of sample compounds utilizing a microfluidic device, comprising:
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computer code that receives a signal corresponding to sample compounds being driven through the microfluidic device, wherein the sample compounds are stored in multiple wells in which markers are stored in known wells;
computer code that analyzes the signal to detect a deviation from a steady state signal, wherein the computer code that analyzes the signal includes computer code that determines if the signal exceeds a threshold deviation;
computer code that identifies a sample compound that caused the threshold deviation; and
a computer readable medium that stores the computer codes. - View Dependent Claims (39, 40)
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41. A computer program product that analyzes an array of sample compounds utilizing a microfluidic device, comprising:
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computer code that receives a signal corresponding to sample compounds being driven through the microfluidic device;
computer code that analyzes the signal to detect a deviation from a steady state signal, wherein the computer code that analyzes the signal includes computer code that determines if the signal exceeds a threshold deviation;
computer code that identifies a sample compound that caused the threshold deviation;
computer code that identifies sample compounds in the signal that are near in time being driven through the microfluidic device to the identified sample compound;
computer code that directs the identified sample compounds to be driven through the microfluidic device again for analysis; and
a computer readable medium that stores the computer codes.
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Specification