Methods and apparatus for brachytherapy treatment of prostate disease

• US 6,558,309 B2
• Filed: 03/09/2001
• Issued: 05/06/2003
• Est. Priority Date: 03/09/2000
• Status: Expired due to Fees

• Current Assignee: Neose Technologies, Inc.
• Original Assignee: Neose Technologies, Inc.
• Inventors: Hogendijk, Michael, Green, Thomas C.
• Primary Examiner(s): Hindenburg, Max F.
• Assistant Examiner(s): WINGOOD, PAMELA LYNN
• Application Number:
  US09/802,335
• Publication Number:
  US 20010056218A1
• Time in Patent Office: 788 Days
• Field of Search: 600/1, 600/2, 600/3, 600/4, 600/5, 600/6, 600/7, 600/8, 604/48
• US Class Current: 600/7
• CPC Class Codes: A61M 2210/166 Prostate
• CPC Class Codes: A61M 25/0105 Steering means as part of the catheter or advancing means; Markers for positioning systems for detection of markers A61B
• CPC Class Codes: A61N 2005/1011 Apparatus for permanent insertion of sources
• CPC Class Codes: A61N 5/1007 Arrangements or means for the introduction of sources into the body
• CPC Class Codes: A61N 5/1027 Interstitial radiation therapy

Abstract

Methods and apparatus are provided for brachytherapy treatment of prostate disease for use in conjunction with needles containing a plurality of radioactive seeds. The apparatus comprises a housing and plunger assembly operable by a single clinician. The plunger is coupled to the housing, so that when the apparatus is actuated the needle is retracted against the plunger and the plurality of radioactive seeds is ejected.

Claims

1. Apparatus for performing brachytherapy with a needle having a lumen containing a plurality of seeds and a distal tip, the apparatus comprising:

a housing having a spiral thread disposed along an interior surface of the bore;

a plunger coupled to the housing, the plunger adapted to be received within the lumen of the needle; and

an actuator disposed within the bore and coupled to the needle, the actuator configured to retract the needle within the bore so that the plunger ejects the plurality of seeds from the distal tip.

2. The apparatus of claim 1, wherein the actuator comprises a mating thread disposed on an exterior surface of the needle, the mating thread engaging the spiral thread disposed along the interior of the bore.

3. The apparatus of claim 1 further comprising a lock configured to selectively restrict motion of the plunger relative to the needle.

4. The apparatus of claim 3 wherein the needle further comprises a slot distal of the mating thread, and the lock is removably received within the slot.

5. The apparatus of claim 2, wherein the housing further comprises a cord bore extending into the bore, the apparatus further comprising:

a swivel coupled to the proximal end of the needle; and

a cord coupled to the swivel and extending through the cord bore.

6. The apparatus of claim 2 further comprising a first swivel attached to the proximal end of the needle.

7. The apparatus of claim 6 further comprising a syringe swivel slidingly received within the bore of the housing, the syringe swivel coupled to the first swivel.

8. The apparatus of claim 7 wherein the housing comprises a first half and a second half, and a hinge joining the first half to the second half.

9. The apparatus of claim 8 wherein the hinge comprises a living hinge.

10. The apparatus of claim 2 wherein the housing further comprises a slot lumen, the slot lumen in communication with the lumen.

11. The apparatus of claim 10 further comprising a pull tab adapted to extend through the slot lumen to engage the needle.

12. The apparatus of claim 11 wherein the pull tab further comprises threads configured to engage the mating thread.

13. The apparatus of claim 1 further comprises measurement indicia for determining a depth of the plunger within the lumen.

14. The apparatus of claim 1 wherein actuator comprises:

a tubular member disposed for rotation in the bore, the actuator having an elongated slot and a central bore;

a needle coupling disposed for rotation and translation in the central bore;

a pin affixed to the needle coupling, extending through the elongated slot in the tubular member, and engaged in the spiral groove; and

a knob affixed to the tubular member, wherein rotation of the knob causes the tubular member to urge the pin along the spiral groove and retract the needle coupling within the central bore.

15. The apparatus of claim 14 further comprising a stop mechanism that permits the plunger to be coupled to the housing with in a predetermined relation.

16. The apparatus of claim 14 wherein the stop mechanism further comprises means for advancing the plunger relative to the housing while retaining the needle in fixed position relative to the housing.

17. A method of ejecting seeds from a needle having a lumen containing a plurality of seeds and a distal tip, the method comprising:

providing apparatus comprising a housing having a bore, a plunger disposed within the bore and coupled to housing, the plunger having a distal end adapted to be disposed within the lumen of the needle;

coupling the needle to the apparatus so that the distal end of the plunger is received within the lumen of the needle until the distal end of the plunger contacts a distal-most of the plurality of seeds; and

actuating the apparatus to retract the needle within the bore of the housing, while the plunger maintains the plurality of seeds stationary with respect to the housing, relative motion between the needle and the plunger causing the plurality of seeds to be ejected from the lumen.

18. The method of claim 17 wherein actuating the apparatus further comprises rotating the needle during retraction of the needle.

19. The method of claim 18 further comprising, prior to actuating the apparatus to retract the needle, actuating the apparatus to advance the plunger distally with respect to the needle and advance a proximal-most one of the plurality of seeds relative to the distal tip of the needle.