System for delivering insulin
First Claim
1. An implantable closed loop insulin delivery system for delivering insulin to a patient, comprising:
- stimulus means for stimulating pancreatic beta cells within a predetermined location of said patient;
sensing means for sensing electrical activity of said beta cells following a said stimulating;
measure means for determining from said sensed electrical activity a measure of the patient'"'"'s blood glucose level; and
insulin delivery means for delivering insulin to said patient in response to a determined said measure greater than a predetermined level, wherein said stimulus means comprises pulse generating means for generating stimulus pulses and lead means for delivery of a stimulus pulse to said predetermined location.
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Abstract
There is provided an implantable system and method for monitoring pancreatic beta cell electrical activity in a patient in order to obtain a measure of a patient'"'"'s insulin demand and blood glucose level. A stimulus generator is controlled to deliver stimulus pulses so as to synchronize pancreatic beta cell depolarization, thereby producing an enhanced electrical signal which is sensed and processed. In a specific embodiment, the signal is processed to determine the start and end of beta cell depolarization, from which the depolarization duration is obtained. In order to reduce cardiac interference, each stimulus pulse is timed to be offset from the QRS signal which can interfere with the pancreas sensing. Additionally, the beta cell signals are processed by a correction circuit, e.g., an adaptive filter, to remove QRS artifacts, as well as artifacts from other sources, such as respiration. The thus obtained insulin demand signal is used either to control delivery of insulin from an implanted insulin pump, or to control ongoing pancreatic stimulation of a form to enhance insulin production.
95 Citations
5 Claims
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1. An implantable closed loop insulin delivery system for delivering insulin to a patient, comprising:
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stimulus means for stimulating pancreatic beta cells within a predetermined location of said patient;
sensing means for sensing electrical activity of said beta cells following a said stimulating;
measure means for determining from said sensed electrical activity a measure of the patient'"'"'s blood glucose level; and
insulin delivery means for delivering insulin to said patient in response to a determined said measure greater than a predetermined level, wherein said stimulus means comprises pulse generating means for generating stimulus pulses and lead means for delivery of a stimulus pulse to said predetermined location. - View Dependent Claims (2, 3, 4, 5)
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Specification