Cardiac ablation instrument

• US 6,558,375 B1
• Filed: 07/14/2000
• Issued: 05/06/2003
• Est. Priority Date: 07/14/2000
• Status: Expired due to Term

• Current Assignee: Cardiofocus Incorporated
• Original Assignee: Cardiofocus Incorporated
• Inventors: Farr, Norman E., Baxter, Lincoln S., Sinofsky, Edward L.
• Primary Examiner(s): Gibson, Roy D.
• Assistant Examiner(s): VRETTAKOS, PETER J
• Application Number:
  US09/616,777
• Time in Patent Office: 1,026 Days
• Field of Search: 606/2-3, 606/7, 606/9, 606/10-16, 606/17, 607/89, 607/88
• US Class Current: 606/16
• CPC Class Codes: A61B 18/22 the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
• CPC Class Codes: A61B 2017/00243 cardiac
• CPC Class Codes: A61B 2018/00351 Heart
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/202 Laser enclosed in a hand-piece
• CPC Class Codes: A61B 2018/2261 with scattering, diffusion or dispersion of light
• CPC Class Codes: A61B 2018/2272 with reflective or refractive surfaces for deflecting the beam A61B2018/2261, A61B2018/2266 take precedence

Abstract

The present invention is directed to a hand held cardiac ablation instrument and methods for irradiating a target ablation site. The instrument can include at least one light transmitting optical fiber and a light diffusing element to create a circumferential or curvilinear lesion. A handle is provided for manual application. The handle can be substantially coaxial or otherwise aligned with the center of the circumferential housing. Light travelling through the light transmitting optical fiber or fibers is scattered in a circular pattern by the light diffusing element. The light diffusing element can include a scattering medium, a reflective end cap, and a reflective surface diametrically opposed to the target ablation site, that interact to provide a substantially uniform distribution of laser radiation throughout the circular target region.

Claims

1. A hand held cardiac ablation instrument comprising:

a light transmitting optical fiber having a proximal end and a distal end, the proximal end being adapted to receive ablative radiation from a radiation source; and

a light diffusing element having light scattering medium and being coupled to the distal end of the optical fiber and configured in a toroidal shape to emit an annular pattern of uniform radiation.

2. The instrument of claim 1, wherein the instrument further comprises an optical transparent tubular housing surrounding at least part of the light diffusing element.

3. The instrument of claim 2, wherein the light scattering medium is disposed within a chamber in the housing.

4. The instrument of claim 3, wherein the scattering medium further comprises a polymeric material having light scattering particles incorporated therein.

5. The instrument of claim 3, wherein the scattering medium has a greater refractive index than the housing.

6. The instrument of claim 1, further comprising a handle substantially coaxial the light diffusing element.

7. The instrument of claim 1, wherein the light diffusing element is in the shape of an open loop so as to allow the loop to be placed around or within a pulmonary vein or artery.

8. The instrument of claim 7, wherein the diameter of the loop is between 10 and 50mm.

9. The instrument of claim 7, wherein the width of the diffusing element is between 1 and 5 mm.

10. The instrument of claim 2, wherein the housing comprises a fluorocarbon polmer.

11. The instrument of claim 4, wherein the light scattering particles are chosen from the group consisting of alumina, silica, and titania compounds and mixtures thereof.

12. The instrument of claim 2, wherein the tubular housing further comprises a distal reflective surface.

13. The instrument of claim 12, wherein the reflective surface comprises a mirror coated surface.

14. The instrument of claim 12, wherein radiation propagating through the fiber enters the scattering medium and a portion of the radiation is scattered outward through the housing, and another portion passes through the scattering medium and is reflected by the reflective surface for retransmission through the scattering medium.

15. The instrument of claim 14, wherein the scattering medium and the reflective end surface interact to provide a substantially uniform axial distribution of radiation over the length of the housing.

16. The instrument of claim 2, wherein the tubular housing is partially coated with a reflective surface substantially diametrically opposed to a target ablation site.

17. The instrument of claim 16, wherein the reflective surface comprises a mirror coated surface.

18. The instrument of claim 16, wherein the reflective surface is gold.

19. The instrument of claim 16, wherein the scattering medium and the reflective surface interact to provide a substantially uniform axial distribution of radiation over the length of the housing to a target ablation site.

20. A hand held cardiac ablation instrument comprising:

a slidably disposed light transmitting optical fiber;

a housing in the shape of an open toroidal loop having a first end adapted to receive the slidably disposed light transmitting optical fiber; and

at least one diffuser chamber coupled to the fiber within the housing.

21. The instrument of claim 20, wherein the diffuser chamber comprises light scattering medium disposed within the housing and coupled to the slidably disposed light transmitting optical fiber.

22. The instrument of claim 20, wherein the scattering medium further comprises a polymeric material having light scattering particles incorporated therein.

23. The instrument of claim 20, wherein the light scattering particles are chosen from the group consisting of alumina, silica, and titania compounds and mixtures thereof.

24. The instrument of claim 20, wherein the housing further comprises a second end with a reflective surface.

25. The instrument of claim 24, wherein the reflective surface comprises a mirror coated surface.

26. The instrument of claim 20, wherein the tubular housing is partially coated with a reflective surface substantially diametrically opposed to a target ablation site.

27. The instrument of claim 26, wherein the reflective surface comprises a mirror coated surface.

28. The instrument of claim 26, wherein the reflective surface is gold.

29. The instrument of claim 20, wherein the scattering medium and the reflective surface interact to provide a substantially uniform axial distribution of radiation over the length of the housing to a target ablation site.

30. A method of ablating cardiac tissue, comprising:

positioning a device in proximity to a target region of cardiac tissue, the device having a light diffusing element coupled to a source of photoablative radiation and configured in a toroidal shape to emit an arcuate pattern of radiation;

applying the device to the target region to induce an curvilinear lesion;

moving the device to a second position;

reapplying the device to the target region to induce a second curvilinear lesion;

repeating the steps of positioning and applying until the lesions are joined together to create a composite circumferential lesion.

31. The method of claim 30, wherein the device is positioned endocardially.

32. The method of claim 30, wherein the device is positioned epicardially.