Methods for modifying surfaces of articles

• US 6,558,734 B2
• Filed: 02/09/2001
• Issued: 05/06/2003
• Est. Priority Date: 02/09/2001
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Koulik, Edouard, Patrick, Cahalan T., Iwata, Hiroo
• Primary Examiner(s): CAMERON, ERMA C
• Application Number:
  US09/779,535
• Publication Number:
  US 20020150671A1
• Time in Patent Office: 816 Days
• Field of Search: 427/2.24, 427/2.3, 427/412.1, 427/379, 427/393.5
• US Class Current: 427/2.24
• CPC Class Codes: A61L 29/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 33/0088 by grafting of a monomer onto the substrate
• CPC Class Codes: B05D 2201/02 Polymeric substrate
• CPC Class Codes: B05D 3/0254 After-treatment
• CPC Class Codes: C08L 83/04 Polysiloxanes

Abstract

This invention relates to methods for preparing articles having modified surfaces. Preferably the articles are medical devices. Preferably the surfaces are elastomeric. Preferably the articles having modified surfaces are useful for immobilizing biologically active agents on the surfaces.

Claims

1. A method for preparing an article having a modified surface, the method comprising:

providing an article having a surface that is partially cured, the surface comprising a polysiloxane and a peroxide;

applying a monomer to coat the surface; and

heating the coated surface under conditions sufficient to provide the modified surface with an attached polymer.

2. The method of claim 1 wherein providing an article having a surface that is partially cured comprises:

providing a surface comprising a peroxide curable polysiloxane and a peroxide; and

processing the surface under conditions sufficient to form a partially-cured surface using a method selected from the group consisting of extruding, molding, and heating.

3. The method of claim 2 wherein the peroxide curable polysiloxane comprises poly(dimethylsiloxane-co-methylvinylsiloxane).

4. The method of claim 2 wherein processing the surface comprises heating the surface by a method selected from the group consisting of conduction, convection, hot air impingement, steam treatment, infrared irradiation, ultraviolet irradiation, microwave irradiation, mechanical shearing, and combinations thereof.

5. A method for preparing a biocompatible medical device comprising:

providing a medical device having a surface that is elastomeric, the surface comprising a polysiloxane and a peroxide;

applying a monomer to coat the surface;

heating the surface under conditions sufficient to provide the modified surface with an attached polymer; and

contacting the surface wit a biologically active agent under conditions sufficient to immobilize the biologically active agent on the surface, wherein the biologically active agent is selected from the group consisting of heparin, albumin, phosphorylcholine, dexamethazone, fibrinokinase, collagen, and combinations thereof.

6. A method for preparing a biocompatible medical device comprising:

providing a medical device having a surface, the surface comprising a polysiloxane and peroxide;

applying an amide-functional monomer to coat the surface;

heating the coated surface under conditions sufficient to provide an amide-functional surface;

treating the amide-functional surface under conditions sufficient to convert at least a portion of the amide-functional surface to an amine-functional surface; and

contacting the surface with a biologically active agent under conditions sufficient to immobilize the biologically active agent on the surface.

7. The method of claim 6 wherein the biologically active agent is selected from the group consisting of heparin, albumin, phosphorylcholine, dexamethazone, fibrinokinase, collagen, and combinations thereof.