Peptides blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis, polynucleotides encoding said peptides and methods of use thereof
First Claim
Patent Images
1. A purified peptide selected from the group consisting of SEQ ID NO:
- 8, SEQ ID NO;
9, SEQ ID NO;
10, SEQ ID NO;
11, SEQ ID NO;
12, SEQ ID NO;
13, SEQ ID NO;
14;
wherein said peptide inhibits the binding of VEGF to KDR.
2 Assignments
0 Petitions
Accused Products
Abstract
The present invention provides peptides which can interact with VEGF and inhibit VEGF interaction with KDR or anti-VEGF antibody thereby inhibiting VEGF mediated angiogenesis or angiogeneis related diseases, polynucleotide encoding the peptides, vectors containing the polynucleotides, pharmaceutical compositions containing the peptides, and methods of inhibiting angiogenesis with the peptides.
93 Citations
13 Claims
-
1. A purified peptide selected from the group consisting of SEQ ID NO:
- 8, SEQ ID NO;
9, SEQ ID NO;
10, SEQ ID NO;
11, SEQ ID NO;
12, SEQ ID NO;
13, SEQ ID NO;
14;
wherein said peptide inhibits the binding of VEGF to KDR. - View Dependent Claims (2, 10)
- 8, SEQ ID NO;
-
3. A purified peptide selected from the group consisting of SEQ ID NO:
- 1, SEQ ID NO;
2, SEQ ID NO;
3, SEQ ID NO;
4, SEQ ID NO;
5, SEQ ID NO;
6, SEQ ID NO;
7;
wherein said peptide inhibits the binding of anti-VEGF antibody to VEGF. - View Dependent Claims (4, 11)
- 1, SEQ ID NO;
- 5. A purified peptide of the sequence ATWLPPR (SEQ ID NO:
Specification