Microfluidic valve and system therefor

• US 6,561,224 B1
• Filed: 02/14/2002
• Issued: 05/13/2003
• Est. Priority Date: 02/14/2002
• Status: Expired due to Fees

• Current Assignee: Hospira Incorporated (Pfizer Inc.)
• Original Assignee: Abbott Laboratories Incorporated
• Inventors: Cho, Steven T.
• Primary Examiner(s): CHAMBERS, A MICHAEL
• Application Number:
  US10/075,416
• Time in Patent Office: 453 Days
• Field of Search: 137/827, 137/831, 251/129.06, 251/368, 251/331
• US Class Current: 137/831
• CPC Class Codes: F15C 5/00 Manufacture of fluid circuit elements; Manufacture of assemblages of such elements integrated circuits
• CPC Class Codes: F16K 2099/0088 Implanted devices
• CPC Class Codes: F16K 99/0001 Microvalves microdevices B81B1/00; manufacture or treatment of devices or systems in or on a substrate B81C1/00; microfluidic structures B01L3/5027; micropumps F04B19/006
• CPC Class Codes: F16K 99/0015 Diaphragm or membrane valves
• CPC Class Codes: F16K 99/0046 using magnets
• CPC Class Codes: F16K 99/0048 using piezoelectric means
• CPC Class Codes: F16K 99/0051 using electrostatic means
• CPC Class Codes: Y10T 137/2191 By non-fluid energy field affecting input [e.g., transducer]
• CPC Class Codes: Y10T 137/2213 Electrically-actuated element [e.g., electro-mechanical transducer]

Abstract

A valve (105) controls fluid flow in a microfluidic system (100). The valve (105) has an input port adapted to receive fluid exerting a predetermined level of pressure on the valve (105) and an output port. The valve (105) has a variable sized aperture disposed perpendicular to the flow of the fluid (119). The aperture varies in size between a relatively small aperture (137) and a relatively large aperture (151). The small aperture (137) prevents the flow of the fluid (119) through the valve (105) responsive to a relatively high level of capillary forces between the fluid (119) and the valve (105) in the small aperture (137). The large aperture (151) permits the flow of the fluid (119) through the valve (105) responsive to a relatively low level of capillary forces between the fluid (119) and the valve (105) in the large aperture (151).

Claims

1. A valve adapted to control the flow of the fluid in a microfluidic system, the valve comprising:

an input port adapted to receive a fluid exerting a predetermined level of pressure on the valve and an output port adapted to provide the fluid, and

a tubular body having a variable sized aperture adapted to vary between a first aperture size and a second aperture size, larger than the first aperture size,

wherein the first aperture size prevents the flow of the fluid through the valve responsive to a first level of capillary forces between the fluid and the tubular body at the first aperture size, and

wherein the second aperture size permits the flow of the fluid through the valve responsive to a second level of capillary forces, less than the first level of capillary, forces, between the fluid and the tubular body at the second aperture;

a first substrate being planar;

a second substrate being planar and disposed opposite to and parallel to the first substrate; and

a bridge element disposed between and adjacent to the first substrate and the second substrate and having an H-shaped cross-section disposed perpendicular to the direction of the flow of the fluid through the valve, the bridge element including;

a first sidewall interconnecting the first substrate and the second substrate;

a second sidewall spaced from the first sidewall and interconnecting the first substrate and the second substrate;

a diaphragm being planar and having a predetermined thickness,

the diaphragm being connected to and extending between the first sidewall and the second sidewall, the diaphragm being disposed between and parallel to the first substrate and the second substrate in a neutral first, unbiased position,

the diaphragm being adapted to move between a first position and a second position toward one of the first substrate and the second substrate;

the valve forming a first aperture of the first aperture size disposed below the diaphragm when the diaphragm is in the first position and defining a first cross-sectional area equal to a first distance between a bottom surface of the diaphragm and a top surface of the first substrate multiplied by a length of the diaphragm that extends between the first sidewall and the second sidewall;

the valve forming a second aperture of the second aperture size disposed below the diaphragm when the diaphragm is in the second position and defining a second cross-sectional area equal to a second distance between a bottom surface of the diaphragm and a top surface of the first substrate multiplied by the length of the diaphragm that extends between the first sidewall and the second sidewall.

2. A valve according to claim 1 wherein the diaphragm is adapted to move between the first position and the second position responsive to a first control signal having a first electrical potential and a second electrical potential, respectively.

3. A valve according to claim 2 wherein the valve further comprises:

a first contact disposed on the first substrate between the first substrate and the second substrate, the first contact being electrically coupled to receive the first control signal,

the diaphragm having a third electrical potential,

the first electrical potential on the first contact interacting with the third electrical potential on the diaphragm to move the diaphragm to the first position, and the second electrical potential on the first contact interacting with the third electrical potential on the diaphragm to move the diaphragm to the second position.

4. A valve according to claim 1 wherein the first substrate is formed from silicon, the second substrate is formed from glass, the first sidewall and the second sidewall are each formed of silicon dioxide, and the diaphragm is formed from polycrystalline silicon.

5. A valve according to claim 1 wherein the first substrate is formed from silicon, the second substrate is formed from glass, the first sidewall and the second sidewall are each formed of silicon dioxide, and the diaphragm is formed from polycrystalline silicon.

6. A valve adapted to control the flow of the fluid in a microfluidic system, the valve comprising:

a parallelepiped shape having an input port adapted to receive a fluid exerting a predetermined level of pressure on the valve and an output port adapted to provide the fluid, and

a variable sized aperture, having a rectangular cross-section disposed perpendicular to the flow of the fluid through the valve, adapted to vary between a first aperture and a second aperture, larger than the first aperture,

wherein the first aperture prevents the flow of the fluid through the valve responsive to a first level of capillary forces between the fluid and the valve in the first aperture, and

wherein the second aperture permits the flow of the fluid through the valve responsive to a second level of capillary forces, less than the first level of capillary forces, between the fluid and the valve in the second aperture,

wherein the valve further includes;

a first substrate being planar;

a second substrate being planar and disposed opposite to and parallel to the first substrate; and

a bridge element disposed between and adjacent to the first substrate and the second substrate and having an H-shaped cross-section disposed perpendicular to the direction of the flow of the fluid through the valve, the bridge element including;

a first sidewall disposed between and adjacent to the first substrate and the second substrate;

a second sidewall disposed between and adjacent to the first substrate and the second substrate;

a diaphragm being planar and having a predetermined thickness,

the diaphragm being disposed between and adjacent to the first sidewall and the second sidewall, the diaphragm being disposed between and parallel to the first substrate and the second substrate,

the diaphragm being adapted to move between a first position and a second position,

the valve forming the first aperture disposed below the diaphragm when the diaphragm is in the first position responsive to a first distance, extending between a bottom surface of the diaphragm and a top surface of the first substrate, multiplied by a length of the diaphragm, extending between the first sidewall and the second sidewall;

the valve forming the second aperture disposed below the diaphragm when the diaphragm is in the second position responsive to a second distance, extending between a bottom surface of the diaphragm and a top surface of the first substrate, multiplied by the length of the diaphragm, extending between the first sidewall and the second sidewall,

wherein the diaphragm is adapted to move between the first position and the second position responsive to a first control signal having a first electrical potential and a second electrical potential, respectively.

wherein the valve further includes;

a first contact disposed on the first substrate between the first substrate and the second substrate, the first contact being electrically coupled to receive the first control signal,

the diaphragm having a third electrical potential,

the first electrical potential on the first contact interacting with the third electrical potential on the diaphragm to move the diaphragm to the first position, and the second electrical potential on the first contact interacting with the third electrical potential on the diaphragm to move the diaphragm to the second position.

7. A valve according to claim 6:

wherein the valve forms a second aperture, larger than the first aperture, disposed above the diaphragm when the diaphragm is in a third position to permit the flow of the fluid through the valve responsive to a second distance, extending between the top surface of the diaphragm and the bottom surface of the second substrate, multiplied by the length of the diaphragm, extending between the first sidewall and the second sidewall;

wherein the diaphragm is adapted to move between the first position and the third position responsive to a second control signal having a first electrical potential and a second electrical potential, respectively.

8. A valve according to claim 7 wherein the valve further comprises:

a second contact disposed on the second substrate between the first substrate and the second substrate, the second contact being electrically coupled to receive the second control signal, and

the first electrical potential on the second contact interacting with the third electrical potential on the diaphragm to move the diaphragm to the first position, and the second electrical potential on the second contact interacting with the third electrical potential on the diaphragm to move the diaphragm to the third position.