Injector device and method for its operation

• US 6,562,006 B1
• Filed: 04/14/2000
• Issued: 05/13/2003
• Est. Priority Date: 04/16/1999
• Status: Expired due to Term

• Current Assignee: Pfizer Health AB (Pfizer Inc.)
• Original Assignee: Pharmacia AB (Pharmacia Corp.)
• Inventors: Hjertman, Birger, Cseke, Rudolf
• Primary Examiner(s): Look, Edward K.
• Assistant Examiner(s): Edgar, Richard A.
• Application Number:
  US09/549,373
• Time in Patent Office: 1,124 Days
• Field of Search: 604/207, 604/208, 604/209, 604/210, 604/211, 604/218, 604/186, 604/187, 604/506, 604/507, 604/181, 604/184, 604/188, 604/200
• US Class Current: 604/208
• CPC Class Codes: A61M 5/2448 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/3146 Priming, e.g. purging, reducing backlash or clearance
• CPC Class Codes: A61M 5/31553 without axial movement of dose setting member
• CPC Class Codes: A61M 5/3156 using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
• CPC Class Codes: A61M 5/3158 performed by axially moving actuator operated by user, e.g. an injection button
• CPC Class Codes: A61M 5/31593 Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
• CPC Class Codes: A61M 5/31595 Pre-defined multi-dose administration by repeated overcoming of means blocking the free advancing movement of piston rod, e.g. by tearing or de-blocking

Abstract

Injector device, and method for its operation, for containers of syringe type, comprising a barrel of axially roughly constant cross-section, a front opening and at least one movable wall inserted in the barrel for displacement of a container content, the injector comprising a) a housing or housing part arranged to receive the container at least axially stationary, b) an integral or composite piston rod arrangement operable to displace the container movable wall at least in the forward direction and c) a track system for controlling or sequencing the piston rod movements, the track system comprising at least one cooperating track and follower, the cooperating track and follower being arranged stationary with respect to the housing and the piston rod respectively, or vice versa, and in cooperation allowing at least one forward for the piston rod. The track system comprises arrangements initiation, dose setting and expulsion of container content.

Claims

1. Injector device for a container of syringe type, comprising a barrel of axially substantially constant cross-section, a front opening and at least one container movable wall inserted in the barrel for displacement of a container content, the injector comprising a) a housing or housing part arranged to receive the container at least axially stationary, b) an integral or composite piston rod arrangement operable to displace the container movable wall at least in the forward direction and c) a track system adapted to control or sequence the piston rod movements, the track system comprising at least one cooperating track and follower, the cooperating track and follower being stationary with respect to the housing and the piston rod respectively, or vice versa, and in cooperation adapted to allow at least forward movement of the piston rod, wherein the track system comprises (i) a first joining track running at least partly transversal to the axial direction, (ii) at least two expelling tracks, each with a first end being connected to the first joining track, and adapted to allow the follower to selectively enter into any one of the expelling tracks, each expelling track running at least partly in the axial direction and in cooperation with the follower adapted to allow forward movement of the piston rod, and (iii) a second joining track, wherein at least one of the expelling tracks intersects the second joining track at a position forward of the first joining track and wherein the second joining track intersects at least one other of the expelling tracks.

2. The injector of claim 1, wherein the at least two expelling tracks are different.

3. The injector of claim 1, wherein the joining track is arranged to give a line guidance in cooperation with the follower.

4. The injector of claim 1, wherein at least one of the expelling tracks comprises a stop surface for the follower, limiting the piston rod forward movement.

5. The injector of claim 4, wherein the at least two expelling tracks have stop surfaces at different axial positions, providing piston rod limitations corresponding to different doses.

6. The injector of claim 4, wherein the stop surface is arranged to allow in cooperation with the follower no further transversal or forward axial movement of the piston rod.

7. The injector of claim 4, wherein the stop surface is arranged at a track knee or branch, allowing in cooperation with the follower a further transversal movement of the piston rod.

8. The injector of claim 7, wherein the track knee or branch is connected to at least one further track knee or branch, the further track knee or branch allowing in cooperation with the follower a further forward axial movement of the piston rod.

9. The injector of claim 1, wherein at least one of the expelling tracks continues towards its second end in a first axial section, a knee or branch and a second axial section.

10. The injector of claim 9, wherein the at least one expelling track continues into a second knee or branch and a third axial section, optionally further repeated.

11. The injector of claim 1, wherein each of at least two expelling tracks continues towards its second end in a first axial section, a knee or branch and a second axial section.

12. The injector of claim 11, wherein the first axial section of each of the at least two expelling tracks have the same axial length, adapted for an initiation step.

13. The injector of claim 1, wherein one or several one-way structures are arranged in the track system to prevent movement in one direction.

14. The injector of claim 13, wherein the one-way structure is arranged for manual control.

15. The injector of claim 1, wherein one or several friction altering structures are arranged in the track system.

16. The injector of claim 1, further comprising displayed information and an information selector, the information and the selector being arranged on the housing part and the piston rod part respectively or vice versa.

17. The injector of claim 16, wherein the selector incorporates one of a window or a pointer.

18. The injector of claim 16, wherein the information is displayed on the housing part or piston rod part carrying the track system.

19. The injector of claim 16, wherein information is displayed in relation to each expelling track.

20. The injector of claim 16, wherein information is displayed in the form of a ring concentric with the container axis.

21. The injector of claim 20, wherein the ring is arranged on the piston rod.

22. The injector of claim 20, wherein information is displayed axially separate from the expelling tracks.

23. An injectable syringe device, comprising a) a barrel of axially substantially constant cross-section, a front opening and at least one container movable wall inserted in the barrel for displacement of a container content, and b) the injector device of claim 1.

90. The injector of claim 1, wherein the track system further comprises an initial track, with one end being connected to the first joining track, allowing the follower to enter from the initial track into the first joining track under forward movement of the piston rod.

91. The injector of claim 90 wherein the initial track is connected to the first joining track at a point where further axial movement is prevented by a wall surface of the joining track.

92. The injector of claim 90, wherein the initial track has a track section allowing forward movement of the piston rod over a predetermined axial length adapted for de-aeration of the container.

93. The injector of claim 90, wherein the initial track has a section allowing forward movement of the piston rod over a predetermined axial length adapted for mixing of a dual or multiple chamber container.

94. The injector of claim 93, wherein the section comprises a screw-threaded track.

95. The injector of claim 94, wherein the screw-threaded track comprises at least two parallel threaded tracks with at least one follower each.

24. Injector device for a container of syringe type, comprising a barrel of axially substantially constant cross-section, a front opening and at least one container movable wall inserted in the barrel for displacement of a container content, the injector comprising a) a housing or housing part arranged to receive the container at least axially stationary, b) an integral or composite piston rod arrangement operable to displace the container movable wall at least in the forward direction and c) a track system adapted to control or sequence the piston rod movements, the track system comprising at least one cooperating track and follower, the cooperating track and follower being stationary with respect to the housing and the piston rod respectively, or vice versa, and in cooperation adapted to allow at least forward movement of the piston rod, wherein the track system comprises (i) a joining track running at least partly transversal to the axial direction, (ii) at least two expelling tracks, each with a first end being connected to the joining track, adapted to allow the follower to selectively enter into any one of the expelling tracks, each expelling track running at least partly in the axial direction and in cooperation with the follower adapted to allow forward movement of the piston rod, and (iii) an initial track, with one end being connected to the joining track, adapted to allow the follower to enter from the initial track to the joining track under forward movement of the piston rod.

25. The injector of claim 24, wherein the initial track is connected to the joining track at a point where further axial movement is prevented by a wall surface of the joining track.

26. The injector of claim 24, wherein the initial track has a track section allowing forward movement of the piston rod over a predetermined axial length, the predetermined axial length preferably being adapted for de-aeration of the container.

27. The injector of claim 24, wherein the initial track has a section allowing forward movement of the piston rod over a predetermined axial length, the predetermined axial length preferably being adapted for mixing of a dual or multiple chamber container.

28. The injector of claim 27, wherein the section comprises a screw-threaded track.

29. The injector of claim 28, wherein the screw-threaded track comprises at least two parallel threaded tracks with at least one follower each.

30. An injectable syringe device, comprising a) a barrel of axially substantially constant cross-section, a front opening and at least one container movable wall inserted in the barrel for displacement of a container content, and b) the injector device of claim 24.

64. The injector of claim 24, wherein the at least two expelling tracks are different.

65. The injector of claim 24, wherein the joining track is arranged to give a line guidance in cooperation with the follower.

66. The injector of claim 24, wherein at least one of the expelling tracks comprises a stop surface for the follower, limiting the piston rod forward movement.

67. The injector of claim 66, wherein the at least two expelling tracks have stop surfaces at different axial positions, providing piston rod limitations corresponding to different doses.

68. The injector of claim 66, wherein the stop surface is arranged to allow in cooperation with the follower no further transversal or forward axial movement of the piston rod.

69. The injector of claim 66, wherein the stop surface is arranged at a track knee or branch, allowing in cooperation with the follower a further transversal movement of the piston rod.

70. The injector of claim 69, wherein the track knee or branch is connected to at least one further track knee or branch, the further track knee or branch allowing in cooperation with the follower a further forward axial movement of the piston rod.

71. The injector of claim 24, wherein at least one of the expelling tracks continues towards its second end in a first axial section, a knee or branch, and a second axial section.

72. The injector of claim 71 wherein the at least one expelling track continues into a second knee or branch and a third axial section, optionally further repeated.

73. The injector of claim 72, wherein the at least one expelling track is of a form selected from the group consisting of a staircase form, a meandering form, a grid form and combinations thereof.

74. The injector of claim 24, wherein each of the at least two expelling tracks continues toward its respective second end in a first axial section, a knee or branch, and a second axial section.

75. The injector of claim 74, wherein the first axial section of each of the at least two expelling tracks have the same axial length, adapted for an initiation step.

76. The injector of claim 24, wherein one or several one-way structures are arranged in the track system to prevent movement in one direction.

77. The injector of claim 76, wherein the one-way structure is arranged for manual control.

78. The injector of claim 24, wherein one or several friction altering structures are arranged in the track system.

79. The injector of claim 24, wherein more than one follower is used for different parts of the track system.

80. The injector of claim 79, wherein the different parts are serially arranged.

81. The injector of claim 79, wherein the different parts are arranged in parallel.

82. The injector of claim 24, further comprising displayed information and an information selector, the information and the selector being arranged on the housing part and the piston rod part, respectively, or vice versa.

83. The injector of claim 82, wherein the selector incorporates one of a window or a pointer.

84. The injector of claim 82, wherein the information is displayed on the same housing part or piston rod part carrying the track system.

85. The injector of claim 82, wherein the information is displayed in relation to each expelling track.

86. The injector of claim 82, wherein the information is displayed in the form of a ring concentric with the container axis.

87. The injector of claim 86, wherein the ring is arranged on the piston rod.

88. The injector of claim 87, wherein the information is displayed between expelling tracks.

89. The injector of claim 86, wherein the information is displayed axially separate from the expelling tracks.

31. Injector device for a container of syringe type, comprising a barrel of axially substantially constant cross-section, a front opening and at least one container movable wall inserted in the barrel for displacement of a container content, the injector comprising a) a housing or housing part arranged to receive the container at least axially stationary, b) an integral or composite piston rod arrangement operable to displace the container movable wall at least in the forward direction and c) a track system adapted to control or sequence the piston rod movements, the track system comprising at least one cooperating track and follower, the cooperating track and follower being stationary with respect to the housing and the piston rod respectively, or vice versa, and in cooperation adapted to allow at least forward movement of the piston rod, wherein the track system comprises a joining track running at least partly transversal to the axial direction, at least two expelling tracks, each with a first end being connected to the joining track, adapted to allow the follower to selectively enter into any one of the expelling tracks, each expelling track running at least partly in the axial direction and in cooperation with the follower adapted to allow forward movement of the piston rod, and more than one follower is used for different parts of the track system.

32. The injector of claim 31, wherein the different parts are serially arranged.

33. The injector of claim 31, wherein the different parts are arranged in parallel.

34. An injectable syringe device, comprising a) a barrel of axially substantially constant cross-section, a front opening and at least one container movable wall inserted in the barrel for displacement of a container content, and b) the injector device of claim 31.

35. Injector device for a container of syringe type, comprising a barrel of axially substantially constant cross-section, a front opening and at least one container movable wall inserted in the barrel for displacement of a container content, the injector comprising a) a housing or housing part arranged to receive the container at least axially stationary, b) an integral or composite piston rod arrangement operable to displace the container movable wall at least in the forward direction and c) a track system adapted to control or sequence the piston rod movements, the track system comprising at least one cooperating track and follower, the cooperating track and follower being stationary with respect to the housing and the piston rod respectively, or vice versa, and in cooperation adapted to allow at least forward movement of the piston rod, wherein the track system comprises a joining track running at least partly transversal to the axial direction, and at least two expelling tracks, each with a first end being connected to the joining track, and adapted to allow the follower to selectively enter into any one of the expelling tracks, each expelling track running at least partly in the axial direction and in cooperation with the follower adapted to allow forward movement of the piston rod, and wherein the injector further comprises information displayed between expelling tracks in the form of a ring concentric with the container axis on the piston rod, and an information selector arranged on the housing part.

36. An injectable syringe device, comprising a) a barrel of axially substantially constant cross-section, a front opening and at least one container movable wall inserted in the barrel for displacement of a container content, and b) the injector device of claim 35.

37. Injector device for a container of syringe type, comprising a barrel of axially substantially constant cross-section, a front opening and at least one container movable wall inserted in the barrel for displacement of a container content, the injector comprising a) a housing or housing part arranged to receive the container at least axially stationary, b) an integral or composite piston rod arrangement operable to displace the container movable wall at least in the forward direction and c) a track system adapted to control or sequence the piston rod movements, the track system comprising at least one cooperating track and follower, the cooperating track and follower being stationary with respect to the housing and the piston rod respectively, or vice versa, and in cooperation adapted to allow at least forward movement of the piston rod, wherein the track system comprises an initial track adapted to allow forward movement of the piston rod, at least a section of the initial track comprising a screw-threaded track, and at least one expelling track having at least a first axial section and a second axial section connected by a transversal section.

38. The injector of claim 37, wherein the transversal section connects the first axial section and the second axial section in a knee form, allowing repeated ejections in cooperation with the follower.

39. The injector of claim 37, wherein the transversal section connects the first axial section and the second axial section in a branch form, allowing the follower to selectively enter into any one of several second axial sections.

40. The injector of claim 37, wherein the initial track further comprises at least a track section having a substantially axial orientation.

41. The injector of claim 37, wherein different followers are arranged for the initial track and the expelling track, each follower being arranged to be out of engagement with its respective track under at least a part of the cooperation when the other follower is in engagement with its track.

42. An injectable syringe device, comprising a) a barrel of axially substantially constant cross-section, a front opening and at least one container movable wall inserted in the barrel for displacement of a container content, and b) the injector device of claim 37.

43. Injector device for a container of syringe type, comprising a barrel of axially substantially constant cross-section, a front opening and at least one container movable wall inserted in the barrel for displacement of a container content, the injector comprising a) a housing or housing part arranged to receive the container at least axially stationary, b) an integral or composite piston rod arrangement operable to displace the container movable wall at least in the forward direction and c) a track system adapted to control or sequence the piston rod movements, the track system comprising at least one cooperating track and follower, the cooperating track and follower being stationary with respect to the housing and the piston rod respectively, or vice versa, and in cooperation adapted to allow at least forward movement of the piston rod, wherein the track system comprises an initial track adapted to allow forward movement of the piston rod, at least one expelling track having at least one axial section adapted to allow forward movement of the piston rod, and different followers arranged for the initial track and expelling track, wherein each follower is arranged to be disengaged with its respective track under at least a part of the cooperation when the other follower is in engagement with its track.

44. The injector of claim 43, wherein the respective follower is disengaged at least for all movement alternatives for the other follower.

45. The injector of claim 43, wherein engagement of the follower for the expelling track substantially coincides with a stop for piston rod forward movement.

46. The injector of claim 43, wherein the track system comprises at least two expelling tracks connected to a common joining track adapted to allow any one of the followers to selectively enter into any one of the expelling tracks, each expelling track running at least partly in the axial direction and in cooperation with any one of the followers adapted to allow forward movement of the piston rod.

47. An injectable syringe device, comprising a) a barrel of axially substantially constant cross-section, a front opening and at least one container movable wall inserted in the barrel for displacement of a container content, and b) the injector device of claim 43.

48. Injector device for a container of syringe type, comprising a barrel of axially substantially constant cross-section, a front opening and at least one container movable wall inserted in the barrel for displacement of a container content, the injector comprising a) a housing or housing part arranged to receive the container at least axially stationary, b) an integral or composite piston rod arrangement operable to displace the container movable wall at least in the forward direction and c) a track system adapted to control or sequence the piston rod movements, the track system comprising at least one cooperating track and follower, the cooperating track and follower being stationary with respect to the housing and the piston rod respectively, or vice versa, and in cooperation adapted to allow at least forward movement of the piston rod, wherein the track system comprises an initial track adapted to allow forward movement of the piston rod and incorporating a screw-threaded track section,

at least one expelling track having at least one axial section adapted to allow forward movement of the piston rod, and

different followers arranged for the initial track and the expelling track.

49. The injector of claim 48, wherein the screw-threaded track section comprises at least two parallel threads and the follower is divided into at least one structure for each thread.

50. An injectable syringe device, comprising a) a barrel of axially substantially constant cross-section, a front opening and at least one container movable wall inserted in the barrel for displacement of a container content, and b) the injector device of claim 48.

51. Injector device for a container of syringe type, comprising a barrel of axially substantially constant cross-section, a front opening and at least one container movable wall inserted in the barrel for displacement of a container content, the injector comprising a) a housing or housing part arranged to receive the container at least axially stationary, b) an integral or composite piston rod arrangement operable to displace the container movable wall at least in the forward direction and c) a track system adapted to control or sequence the piston rod movements, the track system comprising at least one cooperating track and follower, the cooperating track and follower being stationary with respect to the housing and the piston rod respectively, or vice versa, and in cooperation adapted to allow at least forward movement of the piston rod, wherein

the piston rod comprises a penetrating part arranged to penetrate into the container barrel and an extended part at least partially arranged in parallel with the penetrating part to accommodate the at least part of the barrel therebetween, and

at least one track is arranged on the extended part and comprises a joining track running at least partly transverse to the axial direction, and at least two expelling tracks, each with a first end being connected to the joining track and adapted to allow the follower to selectively enter into any one of the expelling tracks, each expelling track running at least partly in the axial direction and in cooperation with the follower adapted to allow forward movement of the piston rod.

52. An injectable syringe device, comprising a) a barrel of axially substantially constant cross-section, a front opening and at least one container movable wall inserted in the barrel for displacement of a container content, and b) the injector device of claim 51.

53. The injector of claim 51, wherein the penetrating part and the extended part are joined together.

54. The injector of claim 51, wherein the piston rod is formed as a single piece.

55. A method for operating an injector device for a container of syringe type, comprising a barrel of axially substantially constant cross-section, a front opening and at least one container movable wall inserted in the barrel for displacement of a container content, the injector comprising a housing or housing part arranged to receive the container at least axially stationary, an integral or composite piston rod arrangement operable to displace the container movable wall at least in the forward direction, the method comprising the steps of:

a) displacing the piston rod forward in a movement having at least a component in the axial direction while holding the device so as to allow flow in an upward direction, performing de-aeration of the container content,

b) rotating the piston rod in a direction different from that of step a), and

c) advancing the piston rod forward in a movement having at least a component in the axial direction, performing ejection of container content.

56. The method of claim 55, further comprising re-rotating the piston rod in a direction different from that of step c) and re-advancing the piston rod forwards to perform an additional ejection of container content.

57. The method of claim 56 wherein the re-advancing of the piston rod has an axial length different from that of step c).

58. The method of claim 56, wherein the re-advancing of the piston rod has an axial length substantially equal to that of step c).

59. The method for operating an injector device for a container of syringe type, comprising a barrel of axially substantially constant cross-section, a front opening and at least one container movable wall inserted in the barrel for displacement of a container content, the injector comprising a housing or housing part arranged to receive the container at least axially stationary, an integral or composite piston rod arrangement operable to displace the container movable wall at least in the forward direction, the method comprising the steps of:

a) moving the piston rod forward in a movement having at least a component in the axial direction, performing mixing of components in a dual or multiple chamber container,

b) displacing the piston rod forward in a movement having at least a component in the axial direction, performing de-aeration of the container content,

c) rotating the piston rod in a direction different from that of step a), and

d) advancing the piston rod forward in a movement having at least a component in the axial direction, performing hereunder ejection of container content.

60. A method for operating an injector device for a container of syringe type, comprising a barrel of axially substantially constant cross-section, a front opening and at least one container movable wall inserted in the barrel for displacement of a container content, the injector comprising a housing or housing part arranged to receive the container at least axially stationary, an integral or composite piston rod arrangement operable to displace the container movable wall at least in the forward direction, the method comprising the steps of:

a) displacing the piston rod forward in a movement having at least a component in the axial direction, the moving step comprising a screw movement,

b) rotating the piston rod in a direction different from that of step a), and

c) advancing the piston rod forward in a movement having at least a component in the axial direction.

61. Injector device for a container of syringe type, comprising a barrel of axially substantially constant cross-section, a front opening and at least one container movable wall inserted in the barrel for displacement of a container content, the injector comprising a) a housing or housing part arranged to receive the container at least axially stationary, b) an integral or composite piston rod arrangement operable to displace the container movable wall at least in the forward direction and c) a track system adapted to control or sequence the piston rod movements, the track system comprising at least one cooperating track and follower, the cooperating track and follower being stationary with respect to the housing and the piston rod respectively, or vice versa, and in cooperation adapted to allow at least forward movement of the piston rod, wherein

at least one de-aeration track is arranged at least partially in the axial direction to allow forward movement of the piston rod a distance adapted for de-aeration of the container,

at least one expelling track is arranged at least partially in the axial direction to allow forward movement of the piston rod a distance adapted for performing dosing from the container, and

at least one transversal track connects the front end of the de-aeration track with the rear end of the expelling track and runs in a direction different from the de-aeration track and the expelling track.

62. The injector of claim 61, wherein the de-aeration track, the transversal track and the expelling track form a continuous track.

63. An injectable syringe device, comprising a) a barrel of axially substantially constant cross-section, a front opening and at least one container movable wall inserted in the barrel for displacement of a container content, and b) the injector device of claim 61.