Bacteria resistant medical devices

• US 6,562,295 B1
• Filed: 06/30/1999
• Issued: 05/13/2003
• Est. Priority Date: 06/30/1999
• Status: Expired due to Term

• Current Assignee: Biolitec Unternehmensbeteiligungs II AG
• Original Assignee: CeramOptec Industries Incorporated (Biolitec AG)
• Inventors: Neuberger, Wolfgang
• Primary Examiner(s): Thornton, Krisanne
• Application Number:
  US09/345,282
• Time in Patent Office: 1,413 Days
• Field of Search: 422/22, 422/24, 422/28, 422/29, 514/2, 514/185, 604/265
• US Class Current: 422/22
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 29/08 Materials for coatings
• CPC Class Codes: A61L 29/14 Materials characterised by their function or physical properties , e.g. lubricating compositions
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent

Abstract

A novel approach to fight bacterial growth on and attachment to medical devices/implants is described. This approach reduces the necessity of the painful and complicated replacement of the medical devices that frequently need to remain in the body for periods of time longer than is recommended using a traditionally sterilized device. Several methods are described to kill bacteria that have attached to the surface of medical devices. Long term use is then possible with those medical devices. Furthermore a medical device is described under this method that has a photosensitizing compound affixed to or near the device surface with means to periodically activate the compound by suitable illumination.

Claims

1. A bacteria resistant medical device comprising:

surfaces having a photosensitizing compound in proximity to or in contact with said surfaces, to provide means to prevent attachment and growth of bacteria and microorganisms; and

means to permit activation of said photosensitizing compound by irradiation with a suitable light source while portions of said device to be irradiated reside under a patient'"'"'s skin.

2. A medical device according to claim 1, wherein said means to permit activation of said photosensitizing compound comprises a wall and said surfaces manufactured from material that is sufficiently translucent to a wavelength required for activating said photosensitizing compound and preferably is essentially transparent to said wavelength.

3. A medical device according to claim 1, wherein said means to permit activation of said photosensitizing compound comprises a wall containing at least two ports running longitudinally into which optical fibers may be placed and said wall and said surfaces being manufactured from material that is sufficiently translucent to a wavelength required for activating said photosensitizing compound and preferably is essentially transparent to said wavelength.

4. A medical device according to claim 1, wherein said photosensitizing compound upon activation produces singlet oxygen to destroy said bacteria and micro-organisms.

5. A medical device according to claim 1, wherein said photosensitizing compound is immobilized on said surface.

6. A medical device according to claim 1, wherein said photosensitizing compound is initially present in a dormant state.

7. A medical device according to claim 1, wherein said photosensitizing compound is releasable from said surface.

8. A medical device according to claim 1, wherein said photosensitizing compound is incorporated into a layer below said surface and is releasable through said surface.

9. A medical device according to claim 7 wherein said released photosensitizing compound then adheres onto or near said surface.

10. A medical device according to claim 8 wherein said released photosensitizing compound then adheres onto or near said surface.

11. A bacteria resistant medical device comprising:

at least one surface, wherein said surface has means to retain a photosensitizing compound in proximity to said surface;

means to introduce said photosensitizing compound to said surface from an outside source to fight bacterial growth and attachment on said surface while portions of said surface to be irradiated reside under a patient'"'"'s skin;

wherein said photosensitizing compound is chosen to aid in the destruction of selected microorganisms/bacteria, and wherein said photosensitizing compound is activatable by a suitable light source.

12. A medical device according to claim 11 wherein said photosensitizing compound is specifically chosen to produce singlet oxygen to destroy said microorganisms/bacteria.

13. A method to fight bacterial attack on medical devices comprising the steps of:

applying a photosensitizing compound to at least some of a medical device'"'"'s surfaces;

introducing said medical device into a patient'"'"'s body and beginning treatment;

applying radiation, at some selected later time, to said surfaces with a suitable wavelength to activate said photosensitizing compound, while said device is still within said patient'"'"'s body;

generating singlet oxygen by said activated photosensitizing compound; and

eliminating bacteria and preventing bacterial encrustation of said device.

14. A method according to claim 13, wherein said step of applying radiation is selectively repeated at periodic intervals.

15. A method according to claim 13, wherein said step of applying radiation is accomplished by irradiation through skin and tissue to reach said medical device.

16. A method according to claim 13, wherein said step of applying radiation is accomplished by transmitting said radiation through an optical fiber.

17. A method according to claim 16 further comprising the steps of:

inserting said optical fiber toward a distal end of said medical device; and

withdrawing said optical fiber at some predetermined rate to apply an appropriate dosage of light energy per square inch.

18. A method according to claim 17, wherein said step of inserting introduces said optical fiber into said medical device and said activation of said photosensitizing compound occurs by transmitting radiation through a wall between said optical fiber and said device'"'"'s surfaces, said wall and surfaces being sufficiently translucent and preferably being essentially transparent to said suitable wavelength.

19. A method according to claim 18, wherein said insertion step is introducing said optical fiber through a port incorporated into said device.

20. A method according to claim 18, wherein said insertion step is inserting said optical fiber through an existing lumen in said medical device.

21. A method according to claim 16, wherein said optical fiber has a diffusing tip at its distal end, thus applying radiation to activate said photosensitizing compound in a geometrically broader manner.

22. A method according to claim 13, wherein said radiation step further comprises the steps of:

irradiating said photosensitizing compound with a first wavelength to excite a dormant photo sensing compound into an active state; and

irradiating said active state of said photosensitizing compound with a second wavelength to activate said photosensitizing compound.