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Thermally stabilized contrast agent

  • US 6,562,320 B1
  • Filed: 06/26/2000
  • Issued: 05/13/2003
  • Est. Priority Date: 02/19/1996
  • Status: Expired due to Term
First Claim
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1. A freeze-dried vesicle-containing ultrasound contrast agent containing at least one bulking agent selected from the group consisting of glycerol, propylene glycol, dextran and polyethylene glycol and at least one freeze-drying stabilizer selected from the group consisting of sucrose, maltose.H2O, trehalose, raffinose and stachyose, wherein the weight ratio of said stabilizer to the vesicles in said agent is at least 10:

  • 1, and said agent has a Tg value in excess of 20°

    C, a Tg′

    value of −

    37°

    C or above, and is thermally stable at temperatures in excess of 20°

    C.

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