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Method of sequencing by oligomer hybridization

  • US 6,562,566 B1
  • Filed: 05/03/2000
  • Issued: 05/13/2003
  • Est. Priority Date: 07/25/1995
  • Status: Expired due to Fees
First Claim
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1. A method of sequencing a DNA fragment by oligomer hybridization, comprising:

  • (a) providing a hybridization matrix comprising single-stranded oligomers composed of DNA and RNA nucleotides, wherein all single-stranded oligomers are adjusted to bring said oligomers to a uniform bond strength that is sequence-independent;

    (b) exposing a DNA fragment of interest to said hybridization matrix;

    (c) determining the positions on said hybridization matrix to which said DNA fragment hybridizes; and

    (d) deducing the sequence of said DNA fragment.

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