Contoured syringe and novel luer hub and methods for embolizing blood vessels
First Claim
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1. A method for inhibiting premature precipitation of a biocompatible polymer in a fluid composition design to form a solid mass in vivo which composition is delivered by microcatheter to a vascular site of a mammal where it precipitates and embolizes the vascular site which method comprises:
- (a) selecting a fluid composition comprising a biocompatible polymer and placing it in a syringe wherein the syringe comprises a syringe body for holding a fluid composition, an ejection port having an annular wall and an orifice which extends from the syringe body to a distal end of said port wherein said annular wall is tapered at the distal end along the length of at least a portion of the ejection port, a means for ejecting the composition in the syringe body through the ejection port and out of the syringe, and a means for mating and syringe body to a microcatheter;
(b) positioning the tip of a microcatheter at a vascular site, wherein said microcatheter comprises a luer hub body for holding a fluid composition, a catheter delivery line attached to luer hub body, and at least one means for mating the hub body to a syringe wherein the annular wall is tapered so that the inner diameter of the ejection port matches the inner diameter of the luer hub when the ejection port is mated with the luer hub, and wherein the tapered distal end of the annular wall minimizes dead space formation between the annular wall and the luer hub body when the luer hub body mates to the syringe;
(c) mating the syringe of (a) above to a microcatheter of (b) above;
(d) ejecting the composition from the syringe into the microcatheter and then into the vascular site under conditions where the biocomptible polymer in the fluid composition precipitates thereby embolizing the vascular line.
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Abstract
Disclosed are novel syringes and catheters for delivering compositions which form solid masses in vivo. These syringes and catheters are particularly useful for delivering embolizing compositions intravascularly.
125 Citations
4 Claims
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1. A method for inhibiting premature precipitation of a biocompatible polymer in a fluid composition design to form a solid mass in vivo which composition is delivered by microcatheter to a vascular site of a mammal where it precipitates and embolizes the vascular site which method comprises:
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(a) selecting a fluid composition comprising a biocompatible polymer and placing it in a syringe wherein the syringe comprises a syringe body for holding a fluid composition, an ejection port having an annular wall and an orifice which extends from the syringe body to a distal end of said port wherein said annular wall is tapered at the distal end along the length of at least a portion of the ejection port, a means for ejecting the composition in the syringe body through the ejection port and out of the syringe, and a means for mating and syringe body to a microcatheter;
(b) positioning the tip of a microcatheter at a vascular site, wherein said microcatheter comprises a luer hub body for holding a fluid composition, a catheter delivery line attached to luer hub body, and at least one means for mating the hub body to a syringe wherein the annular wall is tapered so that the inner diameter of the ejection port matches the inner diameter of the luer hub when the ejection port is mated with the luer hub, and wherein the tapered distal end of the annular wall minimizes dead space formation between the annular wall and the luer hub body when the luer hub body mates to the syringe;
(c) mating the syringe of (a) above to a microcatheter of (b) above;
(d) ejecting the composition from the syringe into the microcatheter and then into the vascular site under conditions where the biocomptible polymer in the fluid composition precipitates thereby embolizing the vascular line. - View Dependent Claims (2, 3)
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4. A method of inhibiting premature precipitation of a biocompatible polymer in a fluid composition designed to form a solid mass in vivo in a mammal which composition is delivered by a microcatheter to a vascular site of the mammal where it precipitates and embolizes the vascular site which method comprises:
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(a) selecting a fluid composition comprising a biocompatible polymer using and placing it into a syringe wherein the syringe comprises a syringe body for holding a fluid material, an ejection port having an annular wall that is tapered along the length of at least a portion of the ejection port, a means for ejecting the composition in the syringe body through the ejection port and out of the syringe, and a means for mating said syringe body to a microcatheter;
(b) positioning the tip of a microcatheter at a vascular site, wherein said microcatheter comprises a luer hub body for holding a fluid material, a catheter delivery line attached to luer hub body, and at least one means for mating the luer hub body to a syringe, wherein the annular wall is tapered so that the inner diameter of the ejection port matches the inner diameter of the luer hub when the ejection port is mated with the luer hub, and wherein said luer hub body has a maximal volumetric capacity of no more than 0.2 cc wherein the ejection port is configured to minimize dead space between the syringe and the luer hub body;
(c) mating the syringe of (a) above to a microcatheter of (b) above;
(d) ejecting the composition from the syringe into the microcatheter and then into the vascular site under conditions where the biocompatible polymer in the fluid composition precipitates thereby embolizing the vascular site.
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Specification