Contoured syringe and novel luer hub and methods for embolizing blood vessels

• US 6,565,551 B1
• Filed: 11/23/1998
• Issued: 05/20/2003
• Est. Priority Date: 06/13/1997
• Status: Expired due to Term

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Micro Therapeutics, Inc. (Medtronic Plc)
• Inventors: Jones, Michael L., Greff, Richard J.
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): BIANCO, PATRICIA
• Application Number:
  US09/197,527
• Time in Patent Office: 1,639 Days
• Field of Search: 604/187, 604/234, 604/240, 604/241, 604/242, 604/264, 604/500, 604/523
• US Class Current: 604/507
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12186 liquid materials adapted to be injected
• CPC Class Codes: A61B 2017/1205 Introduction devices
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61M 31/00 Devices for introducing or retaining media, e.g. remedies, in cavities of the body A61M25/00 takes precedence ; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008
• CPC Class Codes: A61M 31/007 Injectors for solid bodies, e.g. suppositories
• CPC Class Codes: A61M 35/003 Portable hand-held applicators having means for dispensing or spreading integral media hand-held massage devices with liquid delivery A61H7/003
• CPC Class Codes: A61M 37/0069 Devices for implanting pellets, e.g. markers or solid medicaments for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027

Abstract

Disclosed are novel syringes and catheters for delivering compositions which form solid masses in vivo. These syringes and catheters are particularly useful for delivering embolizing compositions intravascularly.

Claims

1. A method for inhibiting premature precipitation of a biocompatible polymer in a fluid composition design to form a solid mass in vivo which composition is delivered by microcatheter to a vascular site of a mammal where it precipitates and embolizes the vascular site which method comprises:

(a) selecting a fluid composition comprising a biocompatible polymer and placing it in a syringe wherein the syringe comprises a syringe body for holding a fluid composition, an ejection port having an annular wall and an orifice which extends from the syringe body to a distal end of said port wherein said annular wall is tapered at the distal end along the length of at least a portion of the ejection port, a means for ejecting the composition in the syringe body through the ejection port and out of the syringe, and a means for mating and syringe body to a microcatheter;

(b) positioning the tip of a microcatheter at a vascular site, wherein said microcatheter comprises a luer hub body for holding a fluid composition, a catheter delivery line attached to luer hub body, and at least one means for mating the hub body to a syringe wherein the annular wall is tapered so that the inner diameter of the ejection port matches the inner diameter of the luer hub when the ejection port is mated with the luer hub, and wherein the tapered distal end of the annular wall minimizes dead space formation between the annular wall and the luer hub body when the luer hub body mates to the syringe;

(c) mating the syringe of (a) above to a microcatheter of (b) above;

(d) ejecting the composition from the syringe into the microcatheter and then into the vascular site under conditions where the biocomptible polymer in the fluid composition precipitates thereby embolizing the vascular line.

2. The method of claim 1 wherein said microcatheter luer hub body has a maximal volumetric capacity of no more than 0.2 cc.

3. The method of claim 1 wherein the annular wall is located at an inner periphery of the ejection port such that the annular wall is adjacent a path of the fluid composition as the fluid composition ejects through the ejection port.

4. A method of inhibiting premature precipitation of a biocompatible polymer in a fluid composition designed to form a solid mass in vivo in a mammal which composition is delivered by a microcatheter to a vascular site of the mammal where it precipitates and embolizes the vascular site which method comprises:

(a) selecting a fluid composition comprising a biocompatible polymer using and placing it into a syringe wherein the syringe comprises a syringe body for holding a fluid material, an ejection port having an annular wall that is tapered along the length of at least a portion of the ejection port, a means for ejecting the composition in the syringe body through the ejection port and out of the syringe, and a means for mating said syringe body to a microcatheter;

(b) positioning the tip of a microcatheter at a vascular site, wherein said microcatheter comprises a luer hub body for holding a fluid material, a catheter delivery line attached to luer hub body, and at least one means for mating the luer hub body to a syringe, wherein the annular wall is tapered so that the inner diameter of the ejection port matches the inner diameter of the luer hub when the ejection port is mated with the luer hub, and wherein said luer hub body has a maximal volumetric capacity of no more than 0.2 cc wherein the ejection port is configured to minimize dead space between the syringe and the luer hub body;

(c) mating the syringe of (a) above to a microcatheter of (b) above;

(d) ejecting the composition from the syringe into the microcatheter and then into the vascular site under conditions where the biocompatible polymer in the fluid composition precipitates thereby embolizing the vascular site.