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Methods of spray drying pharmaceutical compositions

  • US 6,565,885 B1
  • Filed: 12/22/1998
  • Issued: 05/20/2003
  • Est. Priority Date: 09/29/1997
  • Status: Expired due to Term
First Claim
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1. A method for forming a powder comprising perforated microstructures for pharmaceutical applications by spray drying comprising the steps of:

  • providing a feed stock comprising a bioactive agent, surfactant, and a blowing agent wherein said blowing agent is selected from the group consisting of fluorinated compounds, nonfluorinated oils, ammonium salts, alcohols, chloroform, ethyl acetate, acetone, nitrogen, carbon dioxide, camphor, and latex wherein the ratio of blowing agent/surfactant is between 1.0-60 w/w;

    atomizing said feed stock to produce dispersed droplets;

    drying said droplets to form perforated microstructures comprising said bioactive agent and surfactant; and

    collecting said perforated microstructures.

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