Formulations for neutralization of chemical and biological toxants

• US 6,566,574 B1
• Filed: 06/29/2000
• Issued: 05/20/2003
• Est. Priority Date: 06/30/1998
• Status: Expired due to Term

• Current Assignee: National Technology & Engineering Solutions Of Sandia LLC (Honeywell International Inc.)
• Original Assignee: Sandia Corporation (Martin Marietta Corporation)
• Inventors: Tucker, Mark D., Tadros, Maher E.
• Primary Examiner(s): Lovering, Richard D.
• Application Number:
  US09/607,586
• Time in Patent Office: 1,055 Days
• Field of Search: 516/15, 252/186.41, 510/110, 510/372, 510/504, 510/370, 588/200, 588/901, 588/218, 588/221
• US Class Current: 252/186.41
• CPC Class Codes: A62D 2101/02 Chemical warfare substances, e.g. cholinesterase inhibitors
• CPC Class Codes: A62D 3/38 by oxidation; by combustion
• CPC Class Codes: Y10S 588/901 Compositions

Abstract

A formulation and method of making that neutralizes the adverse health effects of both chemical and biological compounds, especially chemical warfare (CW) and biological warfare (BW) agents. The formulation of the present invention non-toxic and non-corrosive and can be delivered by a variety of means and in different phases. The formulation provides solubilizing compounds that serve to effectively render the chemical and biological compounds, particularly CW and BW compounds, susceptible to attack and at least one reactive compound that serves to attack (and detoxify or kill) the compound. The at least one reactive compound can be an oxidizing compound, a nucleophilic compound or a mixture of both. The formulation can kill up to 99.99999% of bacterial spores within one hour of exposure.

Claims

1. A formulation for use in the neutralization of at least one toxant, comprising:

at least two solubilizing compounds, wherein at least one solubilizing compound is a cationic surfactant, said cationic surfactant being a quaternary ammonium salt, and at least one solubilizing compound is a cationic hydrotrope, at least one reactive compound, said reactive compound selected from the group consisting of nucleophilic and oxidizing compounds and water to produce an aqueous formulation, said quaternary ammonium salt having a concentration between approximately 0.1 to approximately 10 weight percent of the aqueous formulation, wherein said at least two solubilizing compounds and at least one reactive compound, when mixed with said water and exposed to at least one toxant, neutralizes said at least one toxant.

2. The formulation of claim 1 wherein the quaternary ammonium salt is selected from the group consisting of cetyltrimethyl ammonium bromide, benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, tetrabutyl ammonium bromide and polymeric quaternary compounds.

3. The formulation of claim 1 further comprising a water-soluble polymer, with concentration between 0 and approximately 10 percent of the aqueous formulation.

4. The formulation of claim 3 wherein the water-soluble polymer is selected from the group consisting of polyvinyl alcohol, guar gum, cationic polydiallyl dimethyl ammonium chloride, non-ionic polydiallyl dimethyl ammonium chloride, and polyacrylamide.

5. The formulation of claim 3 further comprising a corrosion inhibitor.

6. The formulation of claim 5 wherein the corrosion inhibitor is selected from the group consisting of dimethyl ethanolamine, triethanolamine, ethanolamine salts of C9, C10 and C12 diacid mixtures, dicyclohexyl amine nitrite, and N,N-dibenzylamine.

7. The formulation of claim 3 further comprising a fatty alcohol comprised of from 10 to 16 carbon atoms per molecule, with concentration between 0 and approximately 1 percent of the aqueous formulation.

8. The formulation of claim 7 further comprising a catalyst, said catalyst selected from the group consisting of iodosobenzoate and copper amine complexes.

9. The formulation of claim 7 wherein the reactive compound is selected from the group consisting of hydrogen peroxide, urea hydrogen peroxide, hydroperoxycarbonate, oximates, alkoxides, aryloxides, aldehydes, peroxymonosulfate, Fenton'"'"'s reagent, and sodium hypochlorite.

10. A formulation according to claim 9 used in a kit.

11. The formulation according to claim 10 wherein the kit comprises a premixed component comprising the at least two solubilizing agents, the water-soluble polymer, and the fatty alcohol, and a component consisting of the reactive compound, wherein upon mixing with water can be used in neutralization of at least one toxant.

12. The formulation of claim 9 further comprising water as a carrier medium for said formulation to produce an aqueous formulation capable of detoxification of chemical and biological compounds.

13. The formulation of claim 12 wherein the formulation is at a pH of between approximately 8 and approximately 11.

14. The formulation of claim 12 wherein the formulation is at a pH of approximately 9.

15. The formulation of claim 12 wherein the formulation is in a phase selected from the group consisting of a foam, a fog, a gel, an aerosol, and a liquid.

16. The formulation of claim 15 wherein the foam has an expansion ratio of between approximately 20 and 125.

17. The formulation of claim 15 wherein the cationic hydrotrope is selected the group consisting of from tetrapentyl ammonium bromide, triacetyl methyl ammonium bromide, and tetrabutyl ammonium bromide, with concentration between approximately 0.1 and approximately 10 percent of the aqueous formulation.

18. A formulation for use in neutralization of chemical toxants, comprising:

at least two solubilizing compounds, wherein at least one solubilizing compound is a quaternary ammonium salt and at least one solubilizing compound is a cationic hydrotrope;

a water-soluble polymer;

at least one reactive compound said reactive compound selected from the group consisting of nucleophilic and oxidizing compounds, and;

water in a fluidic phase wherein said at least two solubilizing compounds and at least one reactive compounds, when mixed with said water in a fluidic phase yields a formulation that neutralizes chemical toxants.

19. The formulation of claim 18 wherein the formulation is a foam.

20. The formulation of claim 18 wherein the quaternary ammonium salt has a concentration between approximately 0.1 to approximately 10 weight percent of the aqueous formulation, the cationic hydrotrope is selected from the group consisting of tetrapentyl ammonium bromide, triacetyl methyl ammonium bromide, and tetrabutyl ammonium bromide, with concentration between approximately 0.1 and approximately 10 percent of the aqueous formulation, and the water-soluble polymer is selected from the group consisting of polyvinyl alcohol, guar gum, cationic polydiallyl dimethyl ammonium chloride, non-ionic polydiallyl dimethyl ammonium chloride, and polyacrylamide.

21. A formulation for use in neutralization of biological toxants, comprising:

at least one solubilizing compound, selected from the group consisting of a quaternary ammonium salt, a cationic hydrotrope, and a fatty alcohol comprising 8-20 carbon atoms;

at least one reactive compound, wherein said at least one reactive compound is an oxidizer selected from the group consisting of hydrogen peroxide, urea hydrogen peroxide, and hydroperoxycarbonate;

a peroxide activator which reacts with said at least one reactive compound to form hydroxymonocarbonate; and

water, thereby forming a formulation at a pH value of approximately 5 to approximately 12.

22. The formulation of claim 21 further comprising an alcohol having between 2 and 6 carbon atoms.

23. An aqueous formulation for neutralization of at least one toxant, comprising about 4 weight percent of a first quaternary ammonium salt, about 2 weight percent of a first mixture of alcohols, about 0.2 weight percent of a water soluble polymer, about 3 weight percent of a second quaternary ammonium salt, about 1.5 weight percent of a second mixture of alcohols, and about 4 weight percent of oxidizer.