Multiplex sensor and method of use

• US 6,567,678 B1
• Filed: 05/15/2000
• Issued: 05/20/2003
• Est. Priority Date: 12/02/1997
• Status: Expired due to Term

• Current Assignee: Abbott Laboratories Incorporated
• Original Assignee: Abbott Laboratories Incorporated
• Inventors: Pezzaniti, Joseph L., Lindberg, John M., McGlashen, Michael L., Jeng, Tayy-Wen, Oosta, Gary M.
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US09/571,095
• Time in Patent Office: 1,100 Days
• Field of Search: 600/310, 600/318, 600/319, 600/320, 600/316, 600/322, 600/328, 356/364, 356/369, 356/370
• US Class Current: 600/316
• CPC Class Codes: A61B 5/0095 by applying light and detecting acoustic waves, i.e. photoacoustic measurements
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14558 by polarisation
• CPC Class Codes: G01N 21/21 Polarisation-affecting properties G01N21/19 takes precedence

Abstract

A method for using a multiplex sensor that provides enhanced selectivity and sensitivity. In this method, one or more parameters of a sample are measured by means of multiple spectroscopic techniques, and interferences from physiological and spectral variables are reduced or eliminated. One or more parameters of the sample are measured by means of at least two spectroscopic techniques, wherein the at least two different spectroscopic techniques are selected from the group consisting of:

(a) infrared absorbance

(b) scattering

(c) emission

(d) polarization, and

(e) photoacoustics.

Claims

1. A method of determining the concentration of at least one analyte in a sample comprising the steps of:

(a) illuminating said sample with light;

(b) measuring at least one of diattenuation or polarization;

(c) relating the measurement of step (b) to the concentration of said at least one analyte, wherein said at least one analyte is hemoglobin.

2. The method of claim 1, wherein said at least one analyte comprises glucose.