Real time mechanical imaging of the prostate

• US 6,569,108 B2
• Filed: 03/28/2001
• Issued: 05/27/2003
• Est. Priority Date: 03/28/2001
• Status: Expired due to Term

• Current Assignee: ProUroCare Medical, Inc.
• Original Assignee: Profile LLC
• Inventors: Egorov, Vladimir, Sarvazyan, Armen P.
• Primary Examiner(s): Hindenburg; Max F.
• Assistant Examiner(s): SZMAL, BRIAN SCOTT
• Application Number:
  US09/819,419
• Publication Number:
  US 20020143275A1
• Time in Patent Office: 790 Days
• Field of Search: 600/587,439,561,461,595 73/787,818
• US Class Current: 600/587
• CPC Class Codes: A61B 1/31 for the rectum, e.g. proctoscopes, sigmoidoscopes , colonoscopes
• CPC Class Codes: A61B 2562/0219 Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
• CPC Class Codes: A61B 2562/0247 Pressure sensors
• CPC Class Codes: A61B 2562/043 in a linear array
• CPC Class Codes: A61B 5/036 by means introduced into body tracts A61B5/032 and A61B5/035 take precedence
• CPC Class Codes: A61B 5/061 Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body A61B1/00158 takes precedence
• CPC Class Codes: A61B 5/1122 of movement trajectories
• CPC Class Codes: A61B 5/4381 Prostate evaluation or disorder diagnosis
• CPC Class Codes: A61B 5/441 Skin evaluation, e.g. for skin disorder diagnosis
• CPC Class Codes: A61B 8/0825 for diagnosis of the breast, e.g. mammography
• CPC Class Codes: A61B 8/0833 involving detecting or locating foreign bodies or organic structures
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/4254 using sensors mounted on the probe

Abstract

The present invention relates to a method for real time mechanically imaging the prostate with a transrectal probe. In the method, the prostate image is synthesized and displayed in real time during the examination process. In a preferred embodiment, a compact prostate examination device comprises a probe sized to fit within the rectum and having a head with a tactile sensor longer than the axial length of an average prostate, an electronic unit and a display. As the pressure sensing part of the head is pressed against and moved over the prostate, it generates signals characterizing mechanical structure of the examined area. An accelerometer based motion tracking system is mounted in the probe for determining the position of the pressure transducer array during prostate examination. The electronic unit incorporated into the handle of the probe receives the pressure and motion data to calculate mechanical and geometrical features of the prostate and displays it on the display.

Claims

1. A method for real time mechanical imaging the prostate comprising the steps of:

inserting a transrectal probe into a rectum to a predetermined depth, said transrectal probe having a tactile sensor with a linear dimension exceeding an axial length of an average prostate in the range of about 25 mm to about 45 mm;

acquiring pressure response data and motion data from said tactile sensor during movement of said tactile sensor along predetermined trajectories overlaying said prostate;

real time calculating and displaying of one or more pressure profiles which characterize a cross-section of said prostate;

calculating a pattern of pressure gradient responses from said pressure response data and motion data;

synthesizing a mechanical image of the prostate and its inner structure from said pressure gradient responses; and

displaying said one or more pressure profiles and said mechanical image.

2. The method of claim 1 wherein said tactile sensor comprises a tactile sensor array and said movement of said tactile sensor along each of said trajectories is performed with periodic pressing of said tactile sensor array against the prostate.

3. The method of claim 2 wherein before said pressing of said tactile sensor against the prostate further comprising the step of:

adjusting of an initial pressing site to locate the prostate under a center of said tactile sensor.

4. The method of claim 1 wherein said predetermined trajectories are formed of at least one radial trajectory passing through the sphincter along the axis of rectum and at least one lateral trajectory passing from one side of the prostate to the other.

5. The method of claim 2 wherein said periodic pressing is accompanied with oscillating said tactile sensor along the probe axis.

6. The method of claim 1 wherein said pressure profiles are displayed in real time as a function of the deformation of prostate produced by said tactile sensor pressed against the prostate.

7. The method of claim 1 wherein said pressure profiles are displayed as a function of the force applied to said tactile sensor while pressing against the prostate.

8. The method of claim 1 wherein said motion data is obtained from an accelerometer based motion tracking system and position of said tactile sensor relative to the prostate is calculated by the step of integrating linear and angular accelerations.

9. The method of claim 1 wherein said motion data is obtained from a magnetometer based motion tracking system.

10. The method of claim 1 wherein said pressure profiles are displayed as a plurality of color coded lines which gradually disappear losing their brightness and contrast.

11. The method of claim 10 wherein said color coded lines disappear with a time constant of about 1 second.

12. A device for real time mechanical imaging of the prostate comprising:

a probe sized to fit within the rectum and having a head with tactile sensor connected by a shaft to a handle, said tactile sensor having a linear dimension exceeding an axial length of an average prostate in the range of about 25 mm to about 45 mm;

an electronic unit receiving pressure response data and motion data from said tactile sensor;

means for real time calculating pressure profiles which characterize cross-section of the prostate from said pressure response data and motion data;

means for calculating mechanical images of the prostate from said pressure response data and motion data;

a display coupled to said handle for displaying said pressure profiles and said mechanical images of the prostate and its inner structure; and

a control wheel mounted on said handle, said control wheel operating to control said electronic unit.

13. The device of claim 12 wherein said tactile sensor comprises a pressure transducer array and a motion tracking system.

14. The device of claim 13 wherein each pressure transducer in said pressure transducer array is a micro-machined piezoresistive transducer.

15. The device of claim 13 wherein each pressure transducer in said pressure transducer array is a piezopolymer transducer.

16. The device of claim 13 wherein each pressure transducer in said pressure transducer array is a capacitive transducer.

17. The device of claim 13 wherein said motion tracking system comprises a plurality of accelerometers.

18. The device of claim 17 wherein at least two of said plurality of accelerometers have sensitivity axes directed along the axis of the probe to separate gravity and inertial signal components during pressing said tactile sensor against the prostate.

19. The device of claim 18 wherein one of said accelerometers directed along the axis of the probe is located on said shaft at a first end of said handle which is connected to said shaft and is adjacent to the sphincter when said probe is fit within the rectum and a second one of said accelerometers directed along the axis of the probe is located at a second end of said handle.

20. The device of claim 17 wherein at least two of said accelerometers are used as tilt sensors to determinate rotation and elevation angles of said probe during prostate examination.

21. The device of claim 17 wherein at least two of said accelerometers are used to determinate azimuth angular acceleration of said probe during prostate examination.

22. The device of claim 12 wherein said motion tracking system comprises a plurality of magnetometers to determinate probe position during prostate examination.

23. The device of claim 12 wherein said display is connected to said handle through a support equipped with a hinge to fix said display in a first position of an examination mode and a second position of a review mode.

24. The device of claim 12 further comprising a flexible cover which covers said head and said shaft and fixing for attaching said flexible cover to said handle.

25. The device of claim 24 wherein said flexible cover is disposable.

26. The device of claim 12 wherein said tactile sensor comprises pressure transducers made in the form of a sheath covering said head and connected to said shaft by an electrical connector.

27. The device of claim 26 wherein said sheath with pressure transducers is disposable.

28. The device of claim 12 wherein said shaft with said pressure sensing head is removably attached to the handle by an electrical connector.

29. The device of claim 28 wherein said shaft with said pressure sensing head are disposable.

30. A method for real time mechanical imaging tissues or glands comprising the steps of:

applying a probe to said tissues or glands or adjacent to said tissues or glands;

acquiring pressure response data and motion data from said tactile sensor during movement of said tactile sensor along predetermined trajectories;

real time calculating and displaying of one or more pressure profiles which characterize a cross-section of said tissues or glands;

real time calculating a pattern of pressure gradient responses from said pressure response data and motion data;

real time synthesizing a mechanical image of said tissues or glands and its inner structure from said pressure gradient responses; and

real time displaying of said one or more pressure profiles and said mechanical image during examination of said tissue or gland.

31. The method of claim 30 wherein said method is applied during or after drug treatment of said tissue or gland.

32. A system for real time mechanical imaging tissues or glands comprising the steps of:

means for applying a probe to said tissues or glands or adjacent to said tissues or glands;

means for acquiring pressure response data and motion data from said tactile sensor during movement of said tactile sensor along predetermined trajectories;

means for real time calculating and displaying of one or more pressure profiles which characterize a cross-section of said tissues or glands;

means for calculating a pattern of pressure gradient responses from said pressure response data and motion data;

means for synthesizing a mechanical image of said tissues or glands and its inner structure from said pressure gradient responses; and

means for displaying said one or more pressure profiles and said mechanical image during examination of said tissue or gland.

33. The system of claim 32 wherein said probe is applied during or after drug treatment of said tissue or gland.