Systems and methods of use for delivering beneficial agents for revascularizing stenotic bypass grafts and other occluded blood vessels and for other purposes
First Claim
1. An intra-luminal system for locally delivering an infusate liquid comprising at least one beneficial agent to the wall of a lumen in the body of a living being, said system comprising:
- an infusation means for delivering said infusate liquid, said delivery done at an infusate liquid flow rate, said infusate liquid comprising a beneficial agent;
an extraction means for removing an extraction liquid, said removing done at an extraction liquid flow rate, said extraction liquid comprising the beneficial agent, the concentration of the beneficial agent in the extraction liquid either the same or different from the concentration of the beneficial agent in the infusate liquid;
wherein the extraction liquid flow rate exceeds the infusion liquid flow rate.
1 Assignment
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Accused Products
Abstract
A system and method for opening a lumen in an occluded blood vessel, e.g., a coronary bypass graft, of a living being. The system comprises an atherectomy catheter having a working head, e.g., a rotary impacting impeller, and a debris extraction sub-system. The atherectomy catheter is located within a guide catheter. The working head is arranged to operate on, e.g., impact, the occlusive material in the occluded vessel to open a lumen therein, whereupon some debris may be produced. The debris extraction sub-system introduces an infusate liquid at a first flow rate adjacent the working head and withdraws that liquid and some blood at a second and higher flow rate, through the guide catheter to create a differential flow adjacent the working head, whereupon the debris is withdrawn in the infusate liquid and blood for collection outside the being'"'"'s body. A guide wire having an inflatable balloon on its distal end may be used with the atherectomy catheter to block the flow of debris distally, while enabling distal tissues to be perfused with an oxygenating liquid.
346 Citations
38 Claims
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1. An intra-luminal system for locally delivering an infusate liquid comprising at least one beneficial agent to the wall of a lumen in the body of a living being, said system comprising:
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an infusation means for delivering said infusate liquid, said delivery done at an infusate liquid flow rate, said infusate liquid comprising a beneficial agent;
an extraction means for removing an extraction liquid, said removing done at an extraction liquid flow rate, said extraction liquid comprising the beneficial agent, the concentration of the beneficial agent in the extraction liquid either the same or different from the concentration of the beneficial agent in the infusate liquid;
wherein the extraction liquid flow rate exceeds the infusion liquid flow rate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for locally delivering at least one beneficial agent to the wall of a lumen in the body of a living being comprising the steps of:
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A. providing an intra-luminal system comprising an infusate liquid, an infusation means for delivering said at least one beneficial agent, an extraction means for removing an extraction liquid, said infusation means comprising an outlet port, said infusation liquid comprising at least one beneficial agent, B. positioning said intra-luminal system within the body of the being so that said outlet port is within the lumen adjacent a portion of the wall thereof, and C. delivering, at an infusate liquid flow rate, said infusation liquid through said infusation means and out of said outlet port for localized delivery into the adjacent lumen wall portion; and
D. removing via the extraction means, at an extraction liquid flow rate, at least a portion of said infusation liquid;
wherein the extraction liquid flow rate exceeds the infusion liquid flow rate. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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19. An intra-luminal system for locally delivering an infusate liquid comprising at least one beneficial agent to the wall of a lumen in the body of a living being, said system comprising:
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a working head to open the lumen;
an infusation means for delivering said infusate liquid, said delivering done at an infusate liquid flow rate, said infusate liquid comprising a beneficial agent;
an extraction means for removing an extraction liquid, said removing done at an extraction liquid flow rate, said extraction liquid comprising the beneficial agent, the concentration of the beneficial agent in the extraction liquid either the same or different from the concentration of the beneficial agent in the infusate liquid;
wherein the extraction liquid flow rate exceeds the infusion liquid flow rate. - View Dependent Claims (20, 21, 22, 23, 24, 26, 27, 28)
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25. The intra-luminal system of claim wherein said beneficial agent is an antineoplastic agent selected from the group consisting of alkylating agents, antimetabolites, antimitotic agents, antibiotics, hormones, enzymes, cytoprotective agents, biological response modifiers and monoclonal antibodies.
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29. A method for locally delivering at least one beneficial agent to the wall of a lumen in the body of a living being comprising the steps of:
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A. providing an intra-luminal system comprising a working head, infusate liquid, an infusation means for delivering said drug, an extraction means for removing an extraction liquid, said infusation means comprising an outlet port, said infusation liquid comprising at least one beneficial agent, B. positioning said intra-luminal system within the body of the being so that that the working head and said outlet port is within the lumen adjacent a portion of the wall thereof, and C. delivering, at an infusate liquid flow rate, said infusation liquid through said infusation means and out of said outlet port for localized delivery into the adjacent lumen wall portion; and
D. removing via the extraction means, at an extraction liquid flow rate, at least a portion of said infusation liquid;
wherein the extraction liquid flow rate exceeds the infusion liquid flow rate. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38)
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Specification