Fast-acting pharmaceutical compositions and methods of use

• US 6,569,839 B1
• Filed: 11/30/1999
• Issued: 05/27/2003
• Est. Priority Date: 09/16/1998
• Status: Expired due to Fees

• Current Assignee: Douglas William Mckay
• Original Assignee: Douglas William Mckay
• Inventors: McKay, Douglas William
• Primary Examiner(s): Henley, III, Raymond
• Assistant Examiner(s): JAGOE, DONNA A
• Application Number:
  US09/449,637
• Time in Patent Office: 1,274 Days
• Field of Search: 514/54, 514/56, 514/59, 514/169, 514/198, 514/411, 514/818, 514/887
• US Class Current: 514/54
• CPC Class Codes: A61M 1/3627 Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
• CPC Class Codes: A61M 1/63 with means for emptying the suction container, e.g. by interrupting suction
• CPC Class Codes: A61M 1/72 Cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 1/732 Visual indicating means for vacuum pressure
• CPC Class Codes: A61M 1/74 Suction control underwater drainage A61M1/61
• CPC Class Codes: A61M 1/77 Suction-irrigation systems aspiration tips supplying fluids A61M1/85; specific for negative pressure wound therapy A61M1/92; combined with tracheal tubes A61M16/0463
• CPC Class Codes: A61M 2205/123 with incorporated reservoirs
• CPC Class Codes: A61M 3/0201 Cassettes therefor
• CPC Class Codes: A61M 3/0241 the liquid being supplied by gravity
• CPC Class Codes: A61M 3/0245 Containers therefor, e.g. with heating means or with storage means for cannula

Abstract

A pharmaceutical composition comprising at least one local anesthetic, at least one anti-inflammatory agent and at least one antibiotic are disclosed. The local anesthetic has a peak effect no later than about 10 minutes after administration to a mammal, and the anesthetic and anti-inflammatory have a half-life of no greater than about 36 hours after administration. The pharmaceutical composition, thus, advantageously provides rapid relief of pain with a substantially low residual accumulation of active components so that the pharmaceutical composition can be repeatedly or continuously administered to a wound. Embodiments include preparing a medicinal solution including Lidocaine as the local anesthetic, Hydrocortisone sodium succinate as the anti-inflammatory agent, Chloramphenicol as the antibiotic agent and, optionally, Heparin as an anticoagulant. The medicinal solution is continuously administered to treat a wound of a mammal to maintain a constant positive physiological pressure in the treated wound at a pressure to enable permeation of the medicinal solution and fluids from the wound with concomitant periodical suctioning of debris from the wound.

Claims

1. A medicinal solution, comprising about 0.01 to about 5 weight percent of at least one local anesthetic, about 0.01 to about 5 weight percent of at least one anti-inflammatory, about 0.01 to about 5 weight percent of at least one antibiotic, at least one anticoagulant, and a carrier;

wherein the at least one local anesthetic, anti-inflammatory, antibiotic, anticoagulant, and the carrier are, respectively, Lidocaine or a pharmaceutical salt thereof, Hydrocortisone sodium succinate, Chloramphenicol or a pharmaceutical salt thereof and Heparin or a pharmaceutical salt thereof in normal saline.

2. A method of treating a wound of a mammal, the method comprising:

administering the medicinal solution of claim 1 to the wound to treat the wound.

3. The method according to claim 2, comprising directly administering the medicinal solution continuously at a relatively constant rate to the wound.

4. The method according to claim 2, comprising administering the medicinal solution continuously at a rate of about 20 cc/hr to about 100 cc/hr.

5. The method according to claim 2, comprising administering the medicinal solution over a period up to about 3 days.

6. The method according to claim 2, further comprising the step of:

maintaining a relatively constant positive physiological pressure in the wound during and throughout said administration step.