Drug delivery device
First Claim
1. A device to provide the controlled release of a biologically-active agent contained therein to a body, comprising:
- a cap member, formed of a conductive material, preventing the agent from passing outward from the device to the body;
a first conductor electrically and mechanically coupled to the cap member; and
a second conductor electrically and mechanically isolated from the cap member, the first conductor and the second conductor forming a circuit when a voltage potential difference is generated between the first conductor and the second conductor, the voltage potential difference causing ionization of the cap member to enable the biologically-active agent to pass outward from the device to the body.
1 Assignment
0 Petitions
Reexamination
Accused Products
Abstract
An Implantable Medical Device (IMD) for controllably releasing a biologically-active agent such as a drug to a body is disclosed. The IMD includes a catheter having one or more ports, each of which is individually controlled by a respective pair of conductive members located in proximity to the port. According to the invention, a voltage potential difference generated across a respective pair of conductive members is used to control drug delivery via the respective port. In one embodiment of the current invention, each port includes a cap member formed of a conductive material. This cap member is electrically coupled to one of the conductive members associated with the port to form an anode. The second one of the conductive members is located in proximity to the port and serves as a cathode. When the cap member is exposed to a conductive fluid such as blood, a potential difference generated between the conductors causes current to flow from the anode to the catheter, dissolving the cap so that a biologically active agent is released to the body. In another embodiment of the invention, each port is in proximity to a reservoir or other expandable member containing a cross-linked polymer gel of the type that expands when placed within an electrical field. Creation of an electric field between respective conductive members across the cross-linked polymer gel causes the gel to expand. In one embodiment, this expansion causes the expandable member to assume a state that blocks the exit of the drug from the respective port. Alternatively, the expansion may be utilized to assert a force on a bolus of the drug so that it is delivered via the respective port. Drug delivery is controlled by a control circuit that selectively activates one or more of the predetermined ports.
371 Citations
20 Claims
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1. A device to provide the controlled release of a biologically-active agent contained therein to a body, comprising:
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a cap member, formed of a conductive material, preventing the agent from passing outward from the device to the body;
a first conductor electrically and mechanically coupled to the cap member; and
a second conductor electrically and mechanically isolated from the cap member, the first conductor and the second conductor forming a circuit when a voltage potential difference is generated between the first conductor and the second conductor, the voltage potential difference causing ionization of the cap member to enable the biologically-active agent to pass outward from the device to the body. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A device to provide the controlled release of a biologically-active agent to a body, comprising:
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an outer portion extending from a proximal assembly to a tip portion of the device and defining a plurality of ports through which the biologically-active agent is released from the device to the body;
a plurality of reservoirs containing the biologically-active agent, the plurality of reservoirs formed along the outer portion in fluid communication with the plurality of ports;
a plurality of cap members, formed of a conductive material, positioned over the plurality of reservoirs and preventing the agent from passing outward to the body from the plurality of reservoirs through the plurality of ports;
a plurality of conductor pairs, each of the plurality of conductor pairs including a first conductor, extending from the proximal assembly to the tip portion and electrically and mechanically coupled to one reservoir of the plurality of reservoirs, and a second conductor extending from the proximal assembly to the tip portion and electrically and mechanically isolated from the one reservoir, the first conductor and the second conductor forming a circuit when a voltage potential difference is generated between the first conductor and the second conductor, the voltage potential difference causing ionization of a corresponding one of the plurality of cap members to enable the biologically-active agent to flow from the one reservoir to the body through a corresponding port of the plurality of ports. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method of delivering a biologically-active agent to a body, comprising the steps of:
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positioning a device providing the controlled release of the biologically-active along a predetermined location within the body, the device having at least one cap member, formed of a conductive material, preventing the agent from passing outward from the device to the body; and
generating a voltage potential difference between a first conductor electrically and mechanically coupled to the cap member, and a second conductor electrically and mechanically isolated from the cap member, the voltage potential difference causing ionization of the cap member to enable the biologically-active agent to pass outward from the device to the body.
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Specification