Method of preventing short sampling of a capillary or wicking fill device

• US 6,571,651 B1
• Filed: 03/27/2000
• Issued: 06/03/2003
• Est. Priority Date: 03/27/2000
• Status: Expired due to Fees

• Current Assignee: Lifescan Incorporated (Duv Holding Corporation)
• Original Assignee: Lifescan Incorporated (Duv Holding Corporation)
• Inventors: Hodges, Alastair McIndoe
• Primary Examiner(s): NOLAND, THOMAS
• Application Number:
  US09/536,234
• Time in Patent Office: 1,163 Days
• Field of Search: 738/647.2, 738/63, 738/649.1, 73/645.6, 738/648.1, 738/648.3, 738/648.4, 738/648.5, 738/640.1, 738/640.2, 738/645.1, 204/556, 204/403, 295/95, 436/180, 422/55, 422/56, 422/57, 422/58, 422/68.1, 422/69, 422/50, 422/101, 422/102, 435/14, 600/584
• US Class Current: 73/864.72
• CPC Class Codes: A61B 2562/0295 Strip shaped analyte sensors for apparatus classified in A61B5/145 or A61B5/157 disposable multilayered or laminated electrodes G01N27/307; details of handling chemical test elements G01N33/4875
• CPC Class Codes: B01L 2300/0645 Electrodes
• CPC Class Codes: B01L 2300/069 Absorbents; Gels to retain a fluid
• CPC Class Codes: B01L 2300/0825 Test strips
• CPC Class Codes: B01L 2300/0887 Laminated structure
• CPC Class Codes: B01L 2300/165 Specific details about hydrophobic, oleophobic surfaces
• CPC Class Codes: B01L 2400/0406 capillary forces
• CPC Class Codes: B01L 3/5023 with a sample being transported to, and subsequently stored in an absorbent for analysis
• CPC Class Codes: B01L 3/502707 characterised by the manufacture of the container or its components by shaping or joining plastic parts B29C59/00, B29C65/00; by laminating B32B37/00; manufacture of microstructural devices in general B81C
• CPC Class Codes: B01L 3/50273 characterised by the means or forces applied to move the fluids micropumps F04B19/006, of the membrane type F04B43/043
• CPC Class Codes: B01L 3/502738 characterised by integrated valves microvalves F16K99/0001
• CPC Class Codes: B01L 3/502746 characterised by the means for controlling flow resistance, e.g. flow controllers, baffles B01L3/502738 takes precedence
• CPC Class Codes: Y10T 29/49005 Acoustic transducer
• CPC Class Codes: Y10T 29/49007 Indicating transducer
• CPC Class Codes: Y10T 29/49117 Conductor or circuit manufacturing
• CPC Class Codes: Y10T 436/2575 Volumetric liquid transfer

Abstract

The current invention provides a device, and a method for using the device, for ensuring that a capillary or wicking fill device is fully filled. In particular this invention is directed to, but not limited to, use with capillary or wicking action filled electrochemical sensors suitable for use in analyzing blood or interstitial fluids.

Claims

1. A device for sampling a fluid, comprising:

a pre-chamber having a first interior surface, a first volume and a first mesh material of a first mesh size, the pre-chamber being adapted to exert a first capillary force;

a sensing chamber in fluid communication with the pre-chamber, the sensing chamber having a second interior surface, a second volume and a second mesh material of a second mesh size that is smaller than the first mesh size, the sensing chamber being adapted to exert a second capillary force;

wherein the first volume is not less than the second volume, and wherein a differential exists between the first and second capillary forces, the differential being sufficient to cause flow of fluid from the pre-chamber to substantially fill the sensing chamber.

2. The device of claim 1, wherein the first and second mesh materials comprise materials selected from the group consisting of polyolefin, polyester, polyetrafluoroethylene, cellulose, polystyrene, polycarbonate, polysulfone, and mixtures thereof.

3. The device of claim 1, wherein the first mesh material comprises a first fibrous filling material.

4. The device of claim 3, wherein the second mesh material comprises a second fibrous filling material.

5. The device of claim 3, wherein the first and second fibrous filling materials comprise materials selected from the group consisting of polyolefin, polyester, polyetrafluoroethylene, cellulose, polystyrene, polycarbonate, polysulfone, and mixtures thereof.

6. The device of claim 3, wherein the first and second fibrous filling materials comprise non-woven or melt-blown polymers.

7. The device of claim 3, wherein the second mesh material comprises a second porous material.

8. The device of claim 7, wherein the first and second porous materials comprise macroporous membranes comprising polymeric materials selected from the group consisting of polysulfone, polyvinylidenediflouride, polyetrafluoroethylene, cellulose acetate, polymethacrylate, polyacrylate, and mixtures thereof.

9. The device of claim 3, wherein the first and second porous materials comprise materials selected from the group consisting of a sintered powder, a macroporous membrane, and mixtures thereof.

10. The device of claim 1, wherein the first mesh material comprises a first porous material.

11. The device of claim 1, wherein the first mesh material comprises a first powder.

12. The device of claim 11, wherein the second mesh material comprises a powder.

13. The device of claim 12, wherein the first and second powders are insoluble in a sample of the fluid.

14. The device of claim 12, wherein the first and second powders are soluble in a sample of the fluid.

15. The device of claim 12, wherein the first and second powders comprise materials selected from the group consisting of microcrystalline cellulose, soluble salts, insoluble salts, sucrose, and mixtures thereof.

16. The device of claim 1, wherein the first and second mesh materials comprise one or more materials, which can be the same or different, selected from the group consisting of a mesh material, a fibrous filling material, a porous material, and a powder.

17. The device of claim 1, wherein the sensing chamber further comprises electrodes capable of use in an electrochemical cell.

18. The device of claim 17, wherein at least one of the electrodes comprises a noble metal.

19. The device of claim 18, wherein at least one of the electrodes comprises a metal selected from the group consisting of palladium, platinum and silver.

20. The device of claim 1, further comprising a detector capable of detecting a condition wherein the pre-chamber contains a volume of fluid sufficient to substantially fill the sensing chamber.

21. A glucose monitoring strip comprising the device of claim 1.

22. The device of claim 1, wherein the first interior surface further comprises a first surface treatment.

23. The device of claim 22, wherein the second interior surface further comprises a second surface treatment.

24. The device of claim 23, wherein the first and second surface treatments comprise hydrophilic substances.

25. The device of claim 23, wherein the first and second surface treatments comprise hydrophobic substances.

26. The device of claim 23, wherein the first and second surface treatments comprise substances selected from the group consisting of a surfactant, a block copolymer, a hygroscopic compound, an ionizable substances, and mixtures thereof.

27. The device of claim 1, wherein the second interior surface further comprises a second surface treatment.

28. The device of claim 1, wherein the device is further adapted to detect the presence or absence of an analyte in a sample of the fluid.

29. The device of claim 28, wherein the device is further adapted to determine a quantitative measurement of the analyte.

30. The device of claim 29, wherein the analyte comprises a substance selected from the group consisting of lactate, cholesterol, enzymes, nucleic acids, lipids, polysaccharides, metabolites.

31. The device of claim 29, wherein the analyte comprises glucose.

32. The device of claim 1, wherein the fluid comprises a biological fluid.

33. The device of claim 32, wherein the biological fluid comprises a fluid of an animal or plant.

34. The device of claim 33, wherein the fluid is selected from the group consisting of interstitial fluid, blood, tears, expectorate, saliva, urine, semen, vomitus, sputum, fruit juice, vegetable juice, plant sap, and nectar.

35. The device of claim 32, wherein the biological fluid comprises a food product.

36. The device of claim 1, wherein the fluid comprises a non-biological water-based solution.

37. A device for sampling a fluid, comprising:

at least one pre-chamber having a first interior surface and a first volume, the pre-chamber being adapted to exert a first capillary force; and

a sensing chamber in fluid communication with the at least one pre-chamber, the sensing chamber having a second interior surface and a second volume, the sensing chamber being adapted to exert a second capillary force;

wherein the first volume is not less than the second volume, and wherein a differential exists between the first and second capillary forces, the differential being sufficient to cause flow of fluid from the at least one pre-chamber to substantially fill the sensing chamber, and wherein two or more chambers comprise two or more materials, which can be the same or different, selected from the group consisting of a mesh material, a fibrous filling material, and a powder.