Methods for monitoring affective brain function

• US 6,572,562 B2
• Filed: 03/06/2001
• Issued: 06/03/2003
• Est. Priority Date: 03/06/2001
• Status: Active Grant

• Current Assignee: EyeTracking, Inc.
• Original Assignee: EyeTracking, Inc.
• Inventors: Marshall, Sandra P.
• Primary Examiner(s): MAUST, TIMOTHY LEWIS
• Application Number:
  US09/801,068
• Publication Number:
  US 20030078513A1
• Time in Patent Office: 819 Days
• Field of Search: 600/544, 600/545, 600/558, 351/205, 351/209, 351/246
• US Class Current: 600/558
• CPC Class Codes: A61B 3/112 for measuring diameter of pupils
• CPC Class Codes: A61B 5/16 Devices for psychotechnics using teaching or educational appliances G09B1/00 - G09B7/00; Testing reaction times ; Devices for evaluating the psychological state
• CPC Class Codes: A61B 5/163 by tracking eye movement, gaze, or pupil change

Abstract

An evaluation of affective brain function and, more particularly, to the monitoring of such function as an indication of the reception of visual stimulus. Such evaluation primarily involves analyzing dilation responses as a measure of whether the visual stimulus evokes a positive or negative affective response.

Claims

1. A method for assessing a sensory response of a subject to visual stimulus, comprising the steps of:

a) monitoring pupillary response of the subject during exposure to visual stimulus using a suitably adapted apparatus; and

b) translating the pupillary response into data representative of abrupt changes in pupil diameter, wherein abrupt changes are defined by a change in pupil size by 5% or more in less than 20 milliseconds.

2. The method of claim 1 further comprising the step of calculating a dilation index based on the abrupt changes in pupil diameter.

3. The method of claim 1, wherein step a) further comprises monitoring left and right pupillary responses of the subject.

4. The method of claim 1, wherein step a) further comprises monitoring left pupillary response of the subject.

5. The method of claim 1, wherein step b) further comprises subjecting the data to wavelet analysis to minimize light reflex responses.

6. The method of claim 1, wherein the visual stimulus is non-static and step a) further comprises monitoring pupillary response over time.

7. A method for assessing sensory response of a subject to visual stimulus over a period of time being divisible by a number of equal time increments, comprising the steps of:

a) monitoring left and right pupillary response of the subject during exposure to visual stimulus using a suitably adapted apparatus, wherein said pupillary response includes a plurality of dilation reflexes;

b) translating the pupillary response into data representative of the dilation reflexes; and

c) converting the data into a measure of the sensory response over time by calculating an average dilation index during each of said time increments, wherein said dilation index comprises a measure of the dilation reflexes each of the time increments.

8. The method of claim 7, wherein the number of time increments is between 2 and 100.

9. The method of claim 8, wherein the number of time increments is 4.

10. The method of claim 7, wherein step c) further comprises determining the difference between the average dilation index in the right and left eye during each of said time increments.

11. The method of claim 7, wherein step c) further comprises determining the ratio between the average dilation index in the right and left eye during each of said time increments.

12. A method for categorizing a visual stimulus as attractive or aversive, comprising the steps of:

a) monitoring left eye pupillary responses of a subject during exposure to the visual stimulus over a given time period using a suitably adapted apparatus; and

b) translating the pupillary response into data representative of abrupt changes in pupil diameter;

wherein the visual stimulus is categorized as attractive if the left eye demonstrates an average number of abrupt changes per second that is equal to or between one and two, and aversive if the left eye demonstrates an average number of abrupt changes per second that is less than one or more than two.