Implantable device and use therefor
First Claim
1. An implantable device for delivering a pre-selected molecule into systemic circulation, the device comprising in combination:
- (a) a blood permeable element comprising at least one filament anchorable to an inner wall of a blood vessel which when anchored to the inner wall of the vessel permits blood in the vessel to pass therethrough; and
(b) a capsule having the pre-selected molecule disposed therein, wherein the capsule, when introduced into the vessel, is retained within the vessel by the blood permeable element and the pre-selected molecule is released into blood passing the capsule.
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Accused Products
Abstract
Disclosed is an implantable device for delivering a pre-selected molecule, for example, a hormone, into a mammal'"'"'s systemic circulation. The device comprises a blood permeable element that can be anchored to an inner wall of an intact blood vessel. The device also comprises a capsule that is held in place within the blood vessel by the anchored blood permeable element. The capsule encloses viable cells which produce and secrete the pre-selected molecule into blood passing the capsule. The invention also provides a minimally invasive method for percutaneously introducing into a preselected blood vessel the device of the invention.
101 Citations
29 Claims
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1. An implantable device for delivering a pre-selected molecule into systemic circulation, the device comprising in combination:
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(a) a blood permeable element comprising at least one filament anchorable to an inner wall of a blood vessel which when anchored to the inner wall of the vessel permits blood in the vessel to pass therethrough; and
(b) a capsule having the pre-selected molecule disposed therein, wherein the capsule, when introduced into the vessel, is retained within the vessel by the blood permeable element and the pre-selected molecule is released into blood passing the capsule. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. An implantable device for delivering a pre-selected molecule into systemic circulation, the device comprising in combination:
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(a) a blood permeable element comprising a head and a plurality of legs extending therefrom anchorable to an inner wall of a blood vessel which when anchored to the inner wall of the blood vessel permits blood in the vessel to pass therethrough; and
(b) a capsule having the pre-selected molecule disposed therein, wherein the capsule, when introduced into the vessel, is retained within the vessel by the blood permeable element and the pre-selected molecule is released into blood passing the capsule. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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Specification