Bioengineered vascular graft support prostheses

• US 6,572,650 B1
• Filed: 06/11/2001
• Issued: 06/03/2003
• Est. Priority Date: 06/05/1998
• Status: Expired due to Fees

• Current Assignee: Organogenesis Inc. (Organogenesis Holdings, Inc.)
• Original Assignee: Duke University School of Medicine (Duke University), Organogenesis Inc. (Organogenesis Holdings, Inc.)
• Inventors: Davies, Mark, Carr, Robert M. Jr., Huynh, Tam, Abraham, Ginger A., Hagen, Otto Per
• Primary Examiner(s): McDermott, Corrine
• Assistant Examiner(s): Phan, Hieu
• Application Number:
  US09/719,072
• Time in Patent Office: 722 Days
• Field of Search: 623/1.38, 623/1.14, 623/1.27, 623/1.28, 623/1.24, 623/1.25, 623/1-4-
• US Class Current: 623/1.38
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/3629 Intestinal tissue, e.g. small intestinal submucosa
• CPC Class Codes: A61L 27/40 Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
• CPC Class Codes: A61L 27/507 for artificial blood vessels apparatus for applying cells on a blood vessel prosthesis A61F2/062
• CPC Class Codes: B29C 53/40 for articles of definite length, i.e. discrete articles
• CPC Class Codes: B29C 53/562 spirally

Abstract

The invention is directed to bioengineered vascular graft support prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.

Claims

1. A method for producing a collagen tube comprising at least one layer of submucosal collagen of small intestine wherein the method comprises:

(a) rolling the submucosal collagen around a mandrel and over itself one complete revolution to form a two layer submucosal collagen tube;

(b) drying the tube on the mandrel;

(c) contacting the tube with a crosslinking agent to crosslink the collagen;

(d) removing the crosslinking agent by rinsing the tube;

(e) drying the crosslinked tube on the mandrel; and

,

(f) removing the tube from the mandrel.

2. The method of claim 1 further comprising the step

(g) contacting the collagen tube with a peracetic acid to sterilize the collagen tube.

3. A method of using a bioremodelable prosthesis comprising a collagen tube comprising at least one layer of processed tissue matrix of crosslinked submucosal collagen to prevent stretch injury in an autologous vein graft having two ends implanted in the arterial circulation comprising:

(a) removing a segment of vasculature;

(b) anastomosizing a first end of the vein graft;

(c) passing the vein graft through a collagen tube;

(d) anastomosizing a second end of the vein graft; and

,

(e) covering the vein graft and both anastomoses with said collagen tube.