Reflectometer

• US 6,574,425 B1
• Filed: 10/30/1998
• Issued: 06/03/2003
• Est. Priority Date: 10/31/1997
• Status: Expired due to Fees

• Current Assignee: Jack L. Aronowitz, Technical Chemicals & Products Incorporated
• Original Assignee: Jack L. Aronowitz
• Inventors: Weiss, John, Weitman, Irwin
• Primary Examiner(s): Evans, F L
• Application Number:
  US09/183,443
• Time in Patent Office: 1,677 Days
• Field of Search: 356/402, 356/420, 356/39, 356/445, 356/446, 435/14, 250/214.AL, 250/214.B
• US Class Current: 356/402
• CPC Class Codes: G01N 21/255 Details, e.g. use of specially adapted sources, lighting or optical systems
• CPC Class Codes: G01N 21/274 Calibration, base line adjustment, drift correction
• CPC Class Codes: G01N 21/4738 Diffuse reflection precedence is given to G01N21/55 - G01N21/57 if specular component is taken into consideration, e.g. also for testing fluids, fibrous materials
• CPC Class Codes: G01N 21/8483 Investigating reagent band test-element handling not specific to a test method G01N33/4875; analytical elements specific to chemical analysis of biological material G01N33/52; autometer with reagent band G01N35/04

Abstract

A modulated light source emits light to illuminate a target surface which possesses a certain color and shade of color. Light that is reflected from the target surface is detected by an optical detector. The output from the optical detector is processed and fed back to the optical detector to compensate for any shift caused by ambient light, temperature or other external factors, and is differentially amplified to generate an output signal indicative of the color and shade of the target surface. The output signal from the differential amplifier is then demodulated by a synchronous detector to produce a substantially steady DC voltage that is indicative of the color or shade of color at the target surface. Where the target surface color shade is indicative of a certain measurable quantity or quality (such as an analyte concentration), the steady DC voltage is converted using a look-up table or mathematical formula into a corresponding quantity or quality measurement. In performing this conversion, compensation is made for any variations in modulated light source intensity due to temperature change.

Claims

1. A reflectometer, comprising:

a modulated light source for emitting light to illuminate a target surface which possesses a certain color and shade of color;

an optical detector for detecting light that is reflected from the target surface and generating a first output indicative of detected light;

means for processing the first output to generate a feedback signal for application to the optical detector to compensate for any shift in the first output resulting from the detection of ambient light by the optical detector, and differentially amplify the first output to generate a second output; and

a detector for synchronously demodulating the second output to generate a substantially steady DC output voltage that is indicative of the color or shade of color at the target surface.

2. The reflectometer as in claim 1 wherein the modulated light source emits light having an intensity that varies with changes in temperature, the reflectometer further comprising:

a temperature sensor thermo-mechanically coupled to the modulated light source, the sensor generating a third output indicative of temperature of the modulated light source; and

means for mathematically correcting the substantially steady DC output voltage in accordance with the third output to account for detected changes in modulated light source temperature.

3. The reflectometer as in claim 2 wherein the modulated light source comprises at least one light emitting diode, and wherein the temperature sensor comprises a diode means having an operating characteristic substantially complementing that of the light emitting diode.

4. The reflectometer as in claim 1 wherein the modulated light source emits light having an intensity that varies with changes in temperature, the reflectometer further comprising:

a temperature compensator thermo-mechanically coupled to the modulated light source; and

means for having the temperature compensator control operation of the modulated light source to counteract for any variations in light intensity due to changes in modulated light source temperature.

5. The reflectometer as in claim 4 wherein the modulated light source comprises at least one light emitting diode, wherein the temperature compensator comprises a diode, and wherein the means for having comprises a series electrical connection of the diode with the light emitting diode.

6. The reflectometer as in claim 1 wherein the modulated light source emits light having an intensity that varies with changes in voltage drop across the modulated light source, the reflectometer further comprising:

a sensor for measuring voltage drop across the modulated light source during target surface illumination; and

means for mathematically correcting the substantially steady DC output voltage in accordance with the measured voltage drop to account for variations in light intensity.

7. The reflectometer as in claim 1 wherein the optical detector comprises:

a photo transistor for receiving and detecting light that is reflected from the target surface and generating a first differential signal;

a transistor for setting the quiescent operating point and generating a second differential signal; and

means for connecting the photo transistor and transistor at a common emitter connection in a differential configuration.

8. The reflectometer as in claim 7 further comprising a current mirror for supplying fixed constant current into the common emitter connection between the differentially connected photo transistor and transistor.

9. The reflectometer as in claim 7 wherein the means for processing processes the second differential signal to generate the feedback signal for application to the photo transistor to bias the photo transistor to the quiescent operating point.

10. The reflectometer as in claim 9 wherein the means for processing comprises an integrator for comparing the second differential signal to a reference voltage and integrating a result of the comparison to generate the feedback signal, wherein the feedback signal is indicative of an error between the quiescent operating point and a shift caused by DC ambient light detected at the photo transistor.

11. The reflectometer as in claim 1 wherein the modulated light source comprises:

at least two light emitting diodes; and

means for mounting the light emitting diodes each at an orientation angle away from an orientation angle of the optical detector so as to provide for substantially uniform illumination of the target surface with minimal specular reflection to the optical detector.

12. The reflectometer as in claim 11 wherein the two light emitting diodes are of different color.

13. The reflectometer as in claim 1 wherein the detector for synchronously demodulating comprises a full wave synchronous detector producing a DC voltage proportional to the peak to peak voltage of the second output signal.

14. The reflectometer as in claim 1 further including a hand held case for containing the modulated light source, optical detector, amplifier, and synchronous detector.

15. The reflectometer as in claim 14 wherein the target surface comprises a color developing membrane of a transdermal patch, and the hand held case includes a reader head adapted for mating with the color developing membrane of the transdermal patch.

16. The reflectometer as in claim 15 wherein the transdermal patch includes an opening exposing the color developing membrane to view, and the reader head includes a nose configured for insertion into the transdermal patch opening.

17. The reflectometer as in claim 16 wherein the nose of the reader head includes a transparent window for flattening the color developing membrane when the reader head is inserted into the transdermal patch opening.

18. The reflectometer as in claim 16 wherein the opening in the transdermal patch has a certain size and shape, and wherein the nose configuration of the reader head has a complementary size and shape.

19. The reflectometer as in claim 16 wherein the opening is circular, and wherein the nose configuration has a cylindrical shape adapted to fit within the circular opening.

20. The reflectometer as in claim 19 wherein the cylindrical shape of the nose configuration is tapered to allow the reader head to find the circular opening.

21. The reflectometer as in claim 1 further including a desk top case for containing the modulated light source, optical detector, amplifier, and synchronous detector.

22. The reflectometer as in claim 21 wherein the target surface comprises a color developing testing strip, and the desk top case includes a reader site adapted for constraining the color developing test strip.

23. The reflectometer as in claim 1 wherein the target surface color shade is indicative of a certain measurable quantity or quality, the reflectometer further comprising a processor for converting the steady DC voltage indicative of the color or shade of color at the target surface into a corresponding quantity or quality measurement.

24. The reflectometer as in claim 23 further comprising a stored look-up table or mathematical formula correlating steady DC voltage values to corresponding quantity or quality measurements, the processor consulting the look-up table or mathematical formula in making its conversion.

25. The reflectometer as in claim 24 wherein the measurable quantity or quality comprises an analyte concentration.

26. The reflectometer as in claim 25 wherein the analyte concentration comprises either a glucose level or a cholesterol level.

27. The reflectometer as in claim 1 wherein the modulated light source emits light having an intensity that varies with changes in temperature, and wherein the target surface color shade is indicative of a certain measurable quantity or quality, the reflectometer further comprising:

a sensor generating a temperature signal indicative of light source temperature; and

a processor for correcting the steady DC voltage indicative of the color or shade of color at the target surface in accordance with the temperature signal to generate a compensated DC voltage, and for converting the compensated DC voltage into a corresponding quantity or quality measurement.