Guide wire having extendable contact sensors for measuring temperature of vessel walls

• US 6,575,623 B2
• Filed: 10/01/2001
• Issued: 06/10/2003
• Est. Priority Date: 11/10/2000
• Status: Active Grant

• Current Assignee: Cryotherapeutics GMBH
• Original Assignee: Cardiostream, Inc.
• Inventors: Werneth, Randell L.
• Primary Examiner(s): Gutierrez, Diego
• Assistant Examiner(s): Jagan, Mirellys
• Application Number:
  US09/969,557
• Publication Number:
  US 20020067754A1
• Time in Patent Office: 617 Days
• Field of Search: 374/148, 374/166, 374/179, 600/549
• US Class Current: 374/179
• CPC Class Codes: A61B 18/02 by cooling, e.g. cryogenic techniques devices for cooling specific reflex points of the body within cell-life limits A61H39/06
• CPC Class Codes: A61B 2017/0007 Pyrometers
• CPC Class Codes: A61B 2017/00084 Temperature
• CPC Class Codes: A61B 2017/22051 with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation A61B2017/22048, A61B2017/3486 take precedence
• CPC Class Codes: A61B 2018/0262 using a circulating cryogenic fluid
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/6851 Guide wires
• CPC Class Codes: A61B 5/6859 with multiple distal splines
• CPC Class Codes: A61B 5/6885 Monitoring or controlling sensor contact pressure
• CPC Class Codes: A61M 2230/50 Temperature
• CPC Class Codes: A61M 25/09 Guide wires

Abstract

The present invention may be embodied in a device for detection of vulnerable plaque in a vessel based on a temperature increase of the vessel'"'"'s wall. The device may be a guide wire having an extendable assembly having resilient delivery wires for placing the temperature sensor in contact with the vessel'"'"'s inner wall.

Claims

1. A guide wire for sensing inner-wall temperature of a vessel, comprising:

a tube having a lumen within the tube;

a distal end with an opening into the lumen, and an external surface at a relatively constant radius from a generally central axis through the tube;

an inner wire assembly to be located within and slid along the lumen;

the inner wire assembly having a distal end that may be extended through the opening in the distal end of the tube; and

a temperature sensor assembly having

a plurality of temperature sensors; and

a plurality of resilient arcuate delivery wires;

each delivery wire having a proximal end and a distal end;

each delivery wire'"'"'s distal end being attached to the inner wire assembly at a first location near the inner wire assembly'"'"'s distal end and each delivery wire'"'"'s proximal end being attached to the inner wire assembly at a second location spaced apart from first location in a direction away from the inner wire assembly'"'"'s distal end such that a peak is formed by the arcuate delivery wire;

wherein a distance between the peak and the central axis is generally equal to or greater than the tube'"'"'s external radius, and one of the plurality of temperature sensors is located near the peak of each arcuate delivery wire; and

wherein, when the temperature sensor assembly is located within the lumen, the resilient arcuate delivery wires are deformed to fit within the lumen and, when the inner wire assembly is located with respect to the tube such that the temperature sensor assembly is extended beyond the opening, the arcuate delivery wires form the peaks for placing the temperature sensors in contact with the vessel'"'"'s inner wall for sensing the temperature of the vessel'"'"'s inner wall and wherein the wires contact the vessel'"'"'s inner wall with a force of less than about 1.00 pound per square inch of vessel wall.

2. A guide wire as defined in claim 1, wherein the tube includes a guide-wire coil at the tube'"'"'s distal end.

3. A guide wire as defined in claim 1, wherein the delivery wires are preformed of nitinol.

4. A guide wire as defined in claim 1, wherein each delivery wire'"'"'s distal end is fixed to the inner wire assembly at the first location and the delivery wire'"'"'s proximal end is fixed to the inner wire assembly at the second location.

5. A guide wire as defined in claim 1, wherein each delivery wire'"'"'s distal end is fixed to the inner wire assembly at the first location and the delivery wire'"'"'s proximal end is attached to the wire assembly by being fixed to a sliding ring that may slide along the wire assembly as the delivery wires are deformed to fit within the lumen.

6. A guide wire as defined in claim 1, wherein the tube includes an end valve at the tube'"'"'s distal end for sealing the opening when the sensor assembly is within the lumen and is not extended through the opening.

7. A guide wire as defined in claim 1, wherein the distal end of the wire assembly includes a cap for covering the opening when the sensor assembly is within the lumen and is not extended through the opening.

8. A guide wire as defined in claim 1, wherein the inner wire assembly includes a wire having channels for forming feed-through lumens, when the inner wire assembly is placed within the tube'"'"'s lumen, for signal wires coupled to the temperature sensors.

9. A guide wire as defined in claim 1, wherein the temperature sensors are thermo-sensing contact junctions.

10. A guide wire as defined in claim 1, wherein the plurality of temperature sensors comprise at least four sensors.

13. A method for determining the location of a vulnerable plaque in a blood vessel of a subject, said method comprising:

inserting a temperature sensing guide wire of claim 1, 11 or 12 into a blood vessel of the subject;

sliding the inner wire assembly distally so as to extend the distal end thereof through the opening in the distal end of the tube, thereby releasing the resilient arcuate delivery wires such that the temperature sensors contact the vessel'"'"'s inner wall; and

manipulating the guide wire along the vessel'"'"'s inner wall while the temperature sensors contact and report the temperature at various locations along the vessel'"'"'s inner wall; and

determining a location along the vessel'"'"'s inner wall having a higher temperature compared to temperature at other locations, wherein the higher temperature locates the vulnerable plaque in the blood vessel.

11. A guide wire for sensing inner-wall temperature of a vessel, comprising:

a tube having a lumen within the tube;

a distal end with an opening into the lumen, and an external surface at a relatively constant radius from a generally central axis through the tube;

a) inner wire assembly to be located within and slid along the lumen;

the inner wire assembly having a distal end that may be extended through the opening in the distal end of the tube and a wire having channels for forming feed-through lumens, when the inner wire assembly is placed within the tube'"'"'s lumen, for signal wires coupled to temperature sensors;

b) an end valve for sealing the opening when the sensor assembly is within the lumen and is not extended through the opening;

c) a temperature sensor assembly having

a plurality of temperature sensors; and

a plurality of resilient arcuate delivery wires;

each delivery wire having a proximal end and a distal end;

each delivery wire'"'"'s distal end being attached to the inner wire assembly at a first location near the inner wire assembly'"'"'s distal end and each delivery wire'"'"'s proximal end being attached to the inner wire assembly at a second location spaced apart from first location in a direction away from the inner wire assembly'"'"'s distal end such that a peak is formed by the arcuate delivery wire,

wherein a distance between the peak and the central axis is generally equal to or greater than the tube'"'"'s external radius, and one of the plurality of temperature sensors is located near the peak of each arcuate delivery wire; and

wherein, when the temperature sensor assembly is located within the lumen, the resilient arcuate delivery wires are deformed to fit within the lumen and, when the inner wire assembly is located with respect to the tube such that the temperature sensor assembly is extended beyond the opening, the arcuate delivery wires form the peaks for placing the temperature sensors in contact with the vessel'"'"'s inner wall for sensing the temperature of the vessel'"'"'s inner wall.

12. A guide wire for sensing inner-wall temperature of a vessel, comprising:

a tube having a lumen within the tube;

a distal end with an opening into the lumen, and an external surface at a relatively constant radius from a generally central axis through the tube;

an inner wire assembly to be located within and slid along the lumen;

the inner wire assembly comprising a distal end that may be extended through the opening in the distal end of the tube and a wire having channels for forming feed-through lumens for signal wires coupled to the temperature sensors;

an end valve for sealing the opening when the sensor assembly is within the lumen and is not extended through the opening;

a temperature sensor assembly having

a plurality of temperature sensors;

a plurality of resilient arcuate delivery wires;

each delivery wire having a proximal end and a distal end;

each delivery wire'"'"'s distal end being attached to the inner wire assembly at a first location near the inner wire assembly'"'"'s distal end and each delivery wire'"'"'s proximal end being attached to the inner wire assembly at a second location spaced apart from first location in a direction away from the inner wire assembly'"'"'s distal end such that a peak is formed by the arcuate delivery wire;

wherein a distance between the peak and the central axis is generally equal to or greater than the tube'"'"'s external radius, and one of the plurality of temperature sensors is located near the peak of each arcuate delivery wire; and

wherein, when the temperature sensor assembly is located within the lumen, the resilient arcuate delivery wires are deformed to fit within the lumen and, when the inner wire assembly is located with respect to the tube such that the temperature sensor assembly is extended beyond the opening, the arcuate delivery wires form the peaks for placing the temperature sensors in contact with the vessel'"'"'s inner wall for sensing the temperature of the vessel'"'"'s inner wall.