Devices for the inhibition or suppression of cellular proliferation in tubular body structures
First Claim
1. A device for inhibiting the growth or mitigating the extent of disease or undesirable proliferation of cells through the localized delivery of radiation to a natural or synthetic target tissue, comprising one or more substrate layers each layer having at least one source of radiation, and one or more shielding layers arranged adjacent to said one or more substrate layers,wherein said radiation source is comprised of one or more radioactive isotopes, and whereby said one or more shielding layers limits the radiation radiated from said one or more radiation layers through said one or more shielding layers.
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Accused Products
Abstract
A surgically implantable radioactive wrap is positioned around the wall of a body vessel, duct or passageway to maintain patency of these structures by mitigating overexuberant cellular proliferation. Such excessive cellular growth may occur as the result of a disease process or following a trauma or an intentional surgical or intravascular intervention. The device provides for delivery of ionizing radiation to a localized target tissue site. Integral design features provide for the shielding of non-targeted tissues and for the attachment of the device to the target tissue structure. A radiation attenuation element serves to absorb extraneous low-energy electrons incidentally emitted by the treatment source and provides for a more uniform radiation dose distribution through the full thickness of the target tissues. The wrap can be easily applied with minimal handling and with limited radiation exposure to operating personnel.
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Citations
18 Claims
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1. A device for inhibiting the growth or mitigating the extent of disease or undesirable proliferation of cells through the localized delivery of radiation to a natural or synthetic target tissue, comprising one or more substrate layers each layer having at least one source of radiation, and one or more shielding layers arranged adjacent to said one or more substrate layers,
wherein said radiation source is comprised of one or more radioactive isotopes, and whereby said one or more shielding layers limits the radiation radiated from said one or more radiation layers through said one or more shielding layers.
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10. A device for inhibiting the growth or mitigating the extent of disease or undesirable proliferation of cells through the localized delivery of radiation to a natural or synthetic target tissue, comprising one or more substrate layers each layer having at least one source of radiation,
wherein said radiation source is comprised of one or more radioactive isotopes, and wherein the total dose of radiation delivered to tissue is between 10 and 200 Gy at a depth of 2 millimeters.
Specification