Isolated selective organ cooling method and apparatus

• US 6,576,002 B2
• Filed: 01/04/2001
• Issued: 06/10/2003
• Est. Priority Date: 03/24/1998
• Status: Expired due to Term

• Current Assignee: Zoll Circulation Incorporated (Asahi Kasei Corporation)
• Original Assignee: Innercool therapies Incorporated (Taxus Cardium Pharmaceuticals Group, Inc.)
• Inventors: Dobak, John D. III
• Primary Examiner(s): GIBSON, ROY DEAN
• Application Number:
  US09/754,452
• Publication Number:
  US 20010002442A1
• Time in Patent Office: 887 Days
• Field of Search: 607/96, 607/104, 607/106, 607/113, 606/20, 606/24, 606/27, 606/28, 604/113, 604/114, 604/43, 604/264, 604/280, 604/284
• US Class Current: 607/105
• CPC Class Codes: A61B 2018/0212 using an instrument inserted into a body lumen, e.g. catheter
• CPC Class Codes: A61B 2018/0262 using a circulating cryogenic fluid
• CPC Class Codes: A61F 2007/0056 for cooling
• CPC Class Codes: A61F 2007/126 for invasive application, e.g. for introducing into blood vessels
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities

Abstract

A selective organ cooling device with a separate warming device for preventing secondary cooling which can result from cooling the selected organ. The cooling device applies cooling to the blood flowing in a selected blood vessel, while the body temperature control device warms the whole body either directly, or by warming blood returning to the heart from the selected organ, via a vein.

Claims

1. A selective organ cooling system, comprising:

a flexible catheter insertable into a blood vessel serving a selected organ of a patient;

a cooling element attached to a distal end of said catheter, said cooling element comprising a plurality of heat transfer segments, said cooling element further comprising a flexible bellows connecting each of said heat transfer segments to adjacent said heat transfer segments;

a plurality of surface irregularities on each said segment of said cooling element, said surface irregularities being shaped and arranged to create turbulence in adjacent fluid; and

a heat transfer device adapted to apply warming to the remainder of the patient'"'"'s body, exclusive of the selected organ being cooled by said cooling element.

2. A selective organ cooling system as recited in claim 1, wherein:

said surface irregularities comprise a helical ridge and a helical groove formed on each said heat transfer segment; and

said helical ridge on each said heat transfer segment has an opposite helical twist to said helical ridges on adjacent said heat transfer segments.

3. A selective organ cooling system as recited in claim 1, wherein a plurality of said surface irregularities are formed on the interior of each said heat transfer segment, said interior surface irregularities being shaped and arranged to create turbulence in fluid within each said heat transfer segment, said interior surface irregularities having a depth at least equal to the boundary layer thickness of flow within each said heat transfer segment.

4. A selective organ cooling system as recited in claim 3, wherein:

said interior surface irregularities comprise a helical ridge and a helical groove formed within each said heat transfer segment; and

said helical ridge within each said heat transfer segment has an opposite helical twist to said helical ridges within adjacent said heat transfer segments.

5. A method for selectively controlling the temperature of a selected organ of a patient, while preventing whole body cooling, said method comprising:

providing a catheter having a cooling element attached to a distal end thereof, said cooling element comprising a plurality of heat transfer segments separated by flexible bellows;

inserting said catheter through the vascular system of the patient, by flexing said bellows to curve said cooling element as required to place said cooling element in a blood vessel serving the selected organ;

circulating fluid through said cooling element;

creating turbulence in the blood in the selected blood vessel and in said circulated fluid, by creating helical flow with helical ridges and helical grooves on the exterior and interior of each said heat transfer segment of said cooling element;

increasing said turbulence by reversing said helical flow at each said heat transfer segment with said helical ridges and helical grooves having opposite twist from said helical ridges and said helical grooves on adjacent said heat transfer segments;

transferring heat from the blood in the selected blood vessel to said heat transfer segments of said cooling element, and transferring said heat from said heat transfer segments to said circulated fluid, to selectively cool the selected organ; and

applying heat via a warming device to prevent cooling of a substantial portion of the remainder of the patient'"'"'s body, exclusive of the selected organ being cooled.