Non-invasive methods for surgery in the vasculature
First Claim
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1. A non-invasive method for performing surgery in the vasculature of a patient, said method comprising:
- (a) administering intravascularly to said patient a composition comprising, in an aqueous diluent, vesicles comprising a gas or gaseous precursor and a stabilizing compound; and
(b) applying ultrasound to said patient in an amount sufficient to induce activation or rupture of said vesicles.
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Abstract
Novel methods of non-invasive intravascular surgery are disclosed, which include the intravascular administration of a composition comprising gas or gaseous precursor filled vesicles, followed by application of ultrasound in an amount sufficient to induce activation or rupture of the vesicles. The methods optionally also include the step of scanning the patient with diagnostic imaging to determine the presence of the vesicles in the region.
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Citations
77 Claims
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1. A non-invasive method for performing surgery in the vasculature of a patient, said method comprising:
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(a) administering intravascularly to said patient a composition comprising, in an aqueous diluent, vesicles comprising a gas or gaseous precursor and a stabilizing compound; and
(b) applying ultrasound to said patient in an amount sufficient to induce activation or rupture of said vesicles. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
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41. A non-invasive method for the disruption of tissue in the vasculature of a patient, said method comprising:
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(a) administering intravascularly to said patient a composition comprising, in an aqueous diluent, vesicles comprising a gas or gaseous precursor and a stabilizing compound;
(b) scanning the patient with diagnostic imaging to ascertain the presence of said vesicles adjacent to said tissue; and
(c) applying ultrasound to said patient in an amount sufficient to induce activation or rupture of said vesicles adjacent to said tissue. - View Dependent Claims (42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77)
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Specification