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Pharmaceutical compositions for rectal and vaginal administration

  • US 6,576,250 B1
  • Filed: 09/19/2000
  • Issued: 06/10/2003
  • Est. Priority Date: 03/27/1998
  • Status: Expired due to Term
First Claim
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1. A method for delivering an active ingredient to a target area in the rectum of a mammal;

  • comprising the steps of;

    (a) administering in the rectum of a mammal a dosage form comprising a therapeutically effective amount of an active ingredient and at least one effervescent penetration enhancer present in an amount sufficient to increase absorption of said active ingredient across a mucosa layer of said target area, (b) causing said active ingredient and said effervescent penetration enhancer to release from said dosage form at said target area in said rectum and to provide effervescent action at said target area;

    so that said effervescent action promotes the absorption of a therapeutically effective amount of said active ingredient across said target area.

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