Pharmaceutical compositions for rectal and vaginal administration
First Claim
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1. A method for delivering an active ingredient to a target area in the rectum of a mammal;
- comprising the steps of;
(a) administering in the rectum of a mammal a dosage form comprising a therapeutically effective amount of an active ingredient and at least one effervescent penetration enhancer present in an amount sufficient to increase absorption of said active ingredient across a mucosa layer of said target area, (b) causing said active ingredient and said effervescent penetration enhancer to release from said dosage form at said target area in said rectum and to provide effervescent action at said target area;
so that said effervescent action promotes the absorption of a therapeutically effective amount of said active ingredient across said target area.
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Abstract
The pharmaceutical compositions of the present invention comprise rectally and vaginally administerable dosage forms that contain effervescent agents as penetration enhancers for drugs. Effervescence occurs in the rectum or vagina, once the dosage form is administered or at a predetermined time following administration. The effervescent agents can be used alone or in combination with pH adjusting substance, which further promote dissolution and absorption of the active ingredient.
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Citations
9 Claims
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1. A method for delivering an active ingredient to a target area in the rectum of a mammal;
- comprising the steps of;
(a) administering in the rectum of a mammal a dosage form comprising a therapeutically effective amount of an active ingredient and at least one effervescent penetration enhancer present in an amount sufficient to increase absorption of said active ingredient across a mucosa layer of said target area, (b) causing said active ingredient and said effervescent penetration enhancer to release from said dosage form at said target area in said rectum and to provide effervescent action at said target area;
so that said effervescent action promotes the absorption of a therapeutically effective amount of said active ingredient across said target area.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- comprising the steps of;
Specification