Carbohydrate mixture

• US 6,576,251 B1
• Filed: 11/09/1999
• Issued: 06/10/2003
• Est. Priority Date: 01/16/1997
• Status: Expired due to Term

• Current Assignee: nv nutricia
• Original Assignee: nv nutricia
• Inventors: Stahl, Bernd, Sawatzki, Gunther
• Primary Examiner(s): Wilson, James O.
• Assistant Examiner(s): Maier, Leigh C.
• Application Number:
  US09/341,775
• Time in Patent Office: 1,309 Days
• Field of Search: 514/23, 514/25, 514/53, 514/54, 514/58, 514/61, 424/439
• US Class Current: 424/439
• CPC Class Codes: A23L 29/30 containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin products from apiculture A23L21/20; artificial sweetening agents A23L27/30
• CPC Class Codes: A23L 33/125 containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates indigestible substances A23L33/21
• CPC Class Codes: A61K 31/702 Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Abstract

The invention relates to a carbohydrate mixture for dietetic foods administered by the enteral or parenteral route and pharmaceuticals, characterized in that said mixture consists of (a) monosaccharide(s), (b) oligosaccharide(s) (at most hexasaccharides) and (c) polysaccharide(s) (at least heptasaccharides), where the mixing ratio a, b, c, in respect of weight, is: α=1, b=40 to 1000, and c=1 to 50, and in that it contains at least 1 weight percent of fucose occurring either freely and/or bound to an oligosaccharide and/or a polysaccharide. According to the invention, the carbohydrate mixture has both a nutritional and a biological effect which is considerably greater than the corresponding action of the individual constituents.

Claims

1. Carbohydrate mixture for dietetic, enteral and parenteral foods and also pharmaceuticals,

characterised in that

it is made up of a=monosaccharide(s), b=oligosaccharide(s) having 2 to 6 monosaccharide units and c=polysacchanide(s) having 7 or more monosaccharide units with a mixing ratio a:

b;

c, based on weight,

a=1

b=40 to 1000 and

c=1 to 50, and

contains at least 1 wt % fucose in free form and/or in a form bound to an oligosaccharide and/or a polysaccharide.

2. Carbohydrate mixture according to claim 1,

characterised in that

the mixing ratio a: b;

c;

is ca. 1;

80;

20.

3. Carbohydrate mixture according to claim 1, characterised in that it contains at least 5 wt % fucose.

4. Carbohydrate mixture according to claim 3, characterised in that it contains from 5 to 10 wt % fucose.

5. Carbohydrate mixture according to claim 1,

characterised in that

the fucose is bound to the oligosaccharides and polysaccharides as follows:

α

1-2, α

1-3, α

1-4, α

1-6.

6. Carbohydrate mixture according to claim 1,

characterised in that

it contains at least 1 wt % sialic acid(s) in free form and/or a form bound to an oligosaccharide and/or a polysaccharide.

7. Carbohydrate mixture according to claim 6,

characterised in that

it contains 1 to 5 wt % sialic acid(s).

8. Carbohydrate mixture according to claim 6 wherein the sialic acid(s) are in bound form as sialyllactose and/or disialyllactose or disialyllacto-N-tetraose.

9. Carbohydrate mixture according to claim 6

characterised in that the sialic acid(s) is (are) bound to the oligosaccharides as follows:

α

2-3, α

2-6, α

2-8.

10. Carbohydrate mixture according to claim 1,

characterised in that

the monosaccharides essentially consist of the following monomers or the oligosaccharides and polysaccharides are essentially composed of the following monomers, which can be modified by —

OSO3H and/or —

OPO3H groups;

N-acetylnerminic acid, N-glycolyineuraminic acid and/or O-acerylated forms thereof, D-glucose, D-fructose, D-galactose, D-mannose, L-fucose, D-N-acetylglucosamine, D-N-acetylgalactosamine, D-xylose, L-rhamnose, D-arabinose, D-allose, D-talose, L-idose, D-ribose and monosaccharides with carboxyl groups.

11. Carbohydrate mixture according to claim 8 wherein the monosaccharide with a carboxyl group is D-galacturonic acid.

12. Carbohydrate mixture according to claim 1, characterised in that the monosaccharides, oligosaccharides and polysaccharides can be or have been fucosylated and optionally sialylated.

13. A method for prophylaxis and/or treatment of symptoms/diseases, which are connected with the association/adhesion of pathogenic substances and organisms to epithelia or other endogenous cells which comprises administering to an infant in need thereof the mixture of claim 1 in an amount of at least 100 mg/kg body weight/day.

14. A method for prophylaxis and/or treatment of symptoms/diseases, which are connected with the association/adhesion of pathogenic substances and organisms to epithelia or other endogenous cells which comprises administering to an infant in need thereof the mixture of claim 1 in an amount of about 500 mg/kg body weight/day.

15. A method for prophylaxis and/or treatment of symptoms/diseases, which are connected with the association/adhesion of pathogenic substances and organisms to epithella or other endogenous cells which comprises administering to an adult in need thereof the mixture of claim 1 in an amount of at least 200 mg/kg body weight/day.

16. A method for prophylaxis and/or treatment of symptoms/diseases, which are connected with the association/adhesion of pathogenic substances and organisms to epithelia or other endogenous cells which comprises administering to an adult in need thereof the mixture of claim 1 in an amount of about 1 g/kg body weight/day.