Methods, systems, and computer program products for analyzing and presenting NMR lipoprotein-based risk assessment results
First Claim
1. A computer program product for automatically generating personalized lipoprotein-based information for a plurality of subjects, the computer program product comprising:
- a computer readable storage medium having computer readable program code embodied in said medium, said computer-readable program code comprising;
computer readable program code for generating lipoprotein measurement values for a patient'"'"'s blood and/or plasma sample, the lipoprotein measurement values including a plurality of lipoprotein subclass variable measurements, including at least two of;
LDL size, LDL concentration, large HDL concentration, and large VLDL concentration;
computer readable program code for comparing the plurality of patient lipoprotein subclass variable values with respective predetermined test criteria for determining whether the subclass variable values are associated with a higher lower risk of developing coronary heart disease;
computer program code for evaluating the lipoprotein measurement values and generating a reduced target value or values for what represents an optimal or low risk value for selected lipoprotein constituents to provide a patient-specific treatment guideline based on the presence of predetermined risk criteria; and
computer readable program code for automatically generating personalized lipoprotein-based reports for a plurality of patients, wherein the computer program code for generating the report includes computer program code for generating a plurality of risk analysis portions representing lower to higher degrees of risk therein, one for each measured lipoprotein subclass, so that a respective one risk analysis portion is aligned adjacent the corresponding measured subclass lipoprotein value, each of the respective risk analysis portions visually indicating when there is a higher risk of coronary heart disease for the measured value by displaying and/or printing the corresponding degree of risk associated with the measured value within a respective risk analysis portion in a visually accentuated manner to thereby provide a contemporaneous reference guideline for interpretation of the measured value, wherein at least one of the risk analysis portions comprises a plurality of discrete horizontal boxes, each representing a predetermined degree of risk and/or a positive or negative risk association, and wherein the computer readable program code for generating the risk analysis portions comprises computer program code that generates one box with a color enhanced border that is in a different color from the other discrete boxes in that risk analysis portion.
3 Assignments
0 Petitions
Accused Products
Abstract
A method for analyzing a patient'"'"'s risk of coronary heart disease by determining the presence of NMR-derived or based lipoprotein constituent value abnormalities includes determining the presence of atherogenic dyslipidemia based on the existence of a clustering of lipoprotein constituent abnormalities as defined by predetermined test criteria. Computer program products and automatically produced reports for presenting NMR-derived lipoprotein risk assessment based on patient-specific lipoprotein subclass results present the measurement results adjacent to a segmented reference risk analysis portion. The actual measured results are visually aligned and enhanced within the risk analysis portion to provide easy reference and understanding of the results relative to a risk of developing coronary heart disease.
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Citations
49 Claims
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1. A computer program product for automatically generating personalized lipoprotein-based information for a plurality of subjects, the computer program product comprising:
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a computer readable storage medium having computer readable program code embodied in said medium, said computer-readable program code comprising;
computer readable program code for generating lipoprotein measurement values for a patient'"'"'s blood and/or plasma sample, the lipoprotein measurement values including a plurality of lipoprotein subclass variable measurements, including at least two of;
LDL size, LDL concentration, large HDL concentration, and large VLDL concentration;
computer readable program code for comparing the plurality of patient lipoprotein subclass variable values with respective predetermined test criteria for determining whether the subclass variable values are associated with a higher lower risk of developing coronary heart disease;
computer program code for evaluating the lipoprotein measurement values and generating a reduced target value or values for what represents an optimal or low risk value for selected lipoprotein constituents to provide a patient-specific treatment guideline based on the presence of predetermined risk criteria; and
computer readable program code for automatically generating personalized lipoprotein-based reports for a plurality of patients, wherein the computer program code for generating the report includes computer program code for generating a plurality of risk analysis portions representing lower to higher degrees of risk therein, one for each measured lipoprotein subclass, so that a respective one risk analysis portion is aligned adjacent the corresponding measured subclass lipoprotein value, each of the respective risk analysis portions visually indicating when there is a higher risk of coronary heart disease for the measured value by displaying and/or printing the corresponding degree of risk associated with the measured value within a respective risk analysis portion in a visually accentuated manner to thereby provide a contemporaneous reference guideline for interpretation of the measured value, wherein at least one of the risk analysis portions comprises a plurality of discrete horizontal boxes, each representing a predetermined degree of risk and/or a positive or negative risk association, and wherein the computer readable program code for generating the risk analysis portions comprises computer program code that generates one box with a color enhanced border that is in a different color from the other discrete boxes in that risk analysis portion. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 32)
analyzing the lipoprotein measurements and providing at least three different lipoprotein result summary segments, a lipid profile segment and a lipoprotein-subclass profile segment, and a separate metabolic abnormality summary segment, wherein the lipid profile segment presents values for total cholesterol, LDL cholesterol, HDL cholesterol, and Triglycerides, wherein the subclass profile segment presents the results of the lipoprotein measurements for the level and size of LDL particles, the level of large HDL, and the level of large VLDL, and wherein the metabolic abnormality summary segment presents the patient'"'"'s risk identification for having a metabolic abnormality.
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8. A computer program product according to claim 1, wherein the computer readable program code for generating the reports comprises computer program code for arranging the measured lipoprotein values such that the lipoprotein measurement values are substantially vertically aligned relative to one another, and wherein the computer program code for generating the risk analysis portion for LDL particle size generates three discrete boxed segments of risk categories, one associated with lower risk for Pattern A, one associated with intermediate risk for Pattern AB, and one associated with higher risk for Pattern B.
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9. A computer program product according to claim 1, wherein the computer program code for generating lipoprotein measurement values for a patient'"'"'s blood sample comprises computer program code for obtaining NMR-based lipoprotein measurements, and wherein the computer readable program code for comparing the NMR-based lipoprotein measurement values to predetermined test criteria to determine the presence of atherogenic dyslipidemia includes computer program code for comparing the measurement values to predetermined test criteria to determine the presence of small LDL, a low level of large HDL, and an elevated level of large VLDL, whereby the determination is made based on the positive test criteria match of at least two of the conditions.
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10. A computer program product according to claim 1, further comprising computer program code for monitoring the patient'"'"'s lipoprotein measurements over time by automatically comparing data successive personalized patient reports from respective selected patients to identify a decrease, an increase or stability in at least one selected lipoprotein subclass constituent value over time to thereby monitor the trend or impact of drug therapy or other treatment.
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11. A computer program product according to claim 1, wherein the computer code for evaluating processes data associated with selected parameters from both the patient'"'"'s medical and behavioral history.
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12. A computer program product according to claim 1, further comprising computer program code for adjusting the predetermined test criteria as well as the associated risk analysis portions for a particular patient relative to the general population based upon the existence of or susceptibility to an identified high-risk medical condition in the patient.
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13. A computer program product according to claim 1, wherein the measured lipoprotein subclass measured values are presented in columnated numerical format as a quantitative number adjacent a corresponding columnated textual label identifying the corresponding subclass variable value.
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14. A computer program product according to claim 1, further comprising computer program code for electronically generating the report and transmitting the report via email to a physician or clinic.
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15. A computer program product according to claim 2, wherein the computer program code for generating the report comprises computer program code for generating a selectable box adjacent parameters associated with an increased risk of metabolic syndrome or atherogenic dyslipidemia and visually accentuating the box when the increased risk is determined to be present.
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16. A computer program product according to claim 2, wherein the computer readable program code for generating the risk analysis portions in the reports includes computer readable program code for presenting a plurality of the measured lipoprotein subclass values as a series of horizontally extending line graphs which graphically represents the subclass value in a relative continuum of low to high risk, the continuum of low to high risk being defined according to predefined risk criteria associated with statistical data for the general population.
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17. A computer program product according to claim 11, wherein the computer program code evaluates and identifies data that defines whether the patient is diabetic.
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18. A computer program product according to claim 11, wherein the computer program code processes data in the patient'"'"'s history to determine whether the patient has been diagnosed with CHD.
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32. A computer program product according to claim 2, wherein the computer program code for generating the report includes program code for visually accentuating at least one box generated in a risk assessment panel that is separate from the risk analysis portions of the lipoprotein subclass constituent values when an increased risk of metabolic syndrome or atherogenic dyslipidemia is determined to be present.
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19. A computer program product for providing patient specific NMR-measured lipoprotein information, the computer program product comprising:
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a computer readable storage medium having computer readable program code means embodied in said medium, said computer-readable program code means comprising;
computer readable program code for obtaining NMR-measurements for a plurality of lipoprotein subclass constituents including at least LDL particle size, LDL concentration, and large HDL concentration;
computer readable program code for determining a coronary heart disease risk level associated with each of the plurality of NMR-measured lipoprotein subclass measurements;
computer program code for evaluating the lipoprotein measurement values and generating a reduced target value or values for what represents an optimal or low risk value for selected lipoprotein constituents to provide a patient-specific treatment guideline based on the presence of predetermined risk criteria; and
computer readable program code for automatically generating a lipoprotein report for a plurality of patients with data corresponding to patient specific NMR-measured lipoprotein subclasses, the computer readable program code for generating the reports including computer readable program code for generating, for each reported measured subclass value, an adjacently positioned associated risk analysis portion according to predetermined risk criteria associated with the measured subclass value, with the risk for a measured value to be represented in the risk analysis portion in at least one of (i) a color-accentuated manner;
(b) a different selected font relative to adjacent portions of the report;
(c) bolded;
(d) italicized;
(e) circled;
(f) boxed;
(g) underlined; and
(h) highlighted to thereby provide a contemporaneous reference guideline for interpretation of the measured lipoprotein subclass value.- View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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33. A computer program product for providing patient specific NMR-measured lipoprotein information, the computer program product comprising:
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a computer readable storage medium having computer readable program code means embodied in said medium, said computer-readable program code means comprising;
computer readable program code for obtaining NMR-measured measurements for a plurality of lipoprotein subclass constituents including at least LDL particle size, LDL concentration, and large HDL concentration;
computer readable program code for determining a coronary heart disease risk level associated with each of the plurality of NMR-measured lipoprotein subclass measurements;
computer program code for evaluating the lipoprotein measurement values and generating a reduced target value or values for what represents an optimal or low risk value for selected lipoprotein constituents to provide a patient-specific treatment guideline based on the presence of predetermined risk criteria; and
computer readable program code for automatically generating a lipoprotein report for a plurality of patients with data corresponding to patient specific NMR-measured lipoprotein subclasses, the computer readable program code for generating the reports including computer readable program code for generating, for each reported measured subclass value, an adjacently positioned associated risk analysis portion that visually accentuates when there is an increased risk of coronary heart disease associated with the respective lipoprotein subclass measurement to thereby provide a contemporaneous reference guideline for interpretation of the measured lipoprotein subclass value, wherein the computer readable program code means for generating the risk analysis portion presents the LDL particle size value as one of;
Pattern A corresponding to lower risk, Pattern B corresponding to higher risk, and Pattern AB corresponding to an intermediate risk; and
wherein said LDL subclass value is identified in said risk analysis portion by visually enhancing the specified pattern associated with the patient-specific LDL subclass value, and wherein the computer readable program code for generating the risk analysis portion includes computer readable program code for presenting each of a plurality of the measured subclass values as a horizontally extending linear bar graph which graphically represents the subclass value relative to a continuum of low to high risk, the continuum of low to high risk being defined according to predefined risk criteria associated with statistical data for the general population.
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34. A computer program product for automatically generating personalized lipoprotein-based assessed risk of coronary heart disease information for a plurality of subjects, the computer program product comprising:
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a computer readable storage medium having computer readable program code embodied in said medium, said computer-readable program code comprising;
computer readable program code for generating NMR-based lipoprotein measurement values for a patient'"'"'s blood plasma or serum sample, the NMR-based lipoprotein measurement values comprising a plurality of lipoprotein constituent values including a constituent value for LDL particle concentration;
computer readable program code for comparing the LDL particle concentration with predetermined test criteria for determining whether the LDL particle concentration is elevated;
computer readable program code for comparing a plurality of NMR-based lipoprotein subclass constituent values to predetermined test criteria associated with abnormal lipoprotein values to determine if there is a clustering of abnormal values for a plurality of different selected lipoprotein subclass constituents according to predetermined test criteria to determine the presence of a metabolic abnormality or atherogenic dyslipidemia;
computer program code for evaluating the lipoprotein measurement values and generating a reduced target value or values for what represents an optimal or low risk value for selected lipoprotein constituents to provide a patient-specific treatment guideline based on the presence of predetermined risk criteria; and
computer readable program code for assessing a patient'"'"'s risk of coronary heart disease based on the presence of at least one of an elevated LDL particleconcentration and/or the metabolic abnormality or atherogenic dyslipidemia. - View Dependent Claims (35, 36)
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37. A computer program product for automatically generating personalized lipoprotein-based assessed risk of coronary heart disease information for a plurality of subjects, the computer program product comprising:
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a computer readable storage medium having computer readable program code embodied in said medium, said computer-readable program code comprising;
computer readable program code for generating NMR-based lipoprotein measurement values for a patient'"'"'s blood plasma or serum sample, the NMR-based lipoprotein measurement values comprising a plurality of lipoprotein constituent values including a constituent value for LDL particle concentration;
computer readable program code for comparing the LDL particle concentration with predetermined test criteria for determining whether the LDL particle concentration is elevated;
computer readable program code for comparing a plurality of NMR-based lipoprotein subclass constituent values to predetermined test criteria associated with abnormal lipoprotein values exist to determine if a clustering of abnormal values exist to determine the presence of a metabolic abnormality or atherogenic dyslipidemia;
computer readable program code for assessing a patient'"'"'s risk of coronary heart disease based on the presence of at least one of an elevated LDL particle concentration and/or the metabolic abnormality or atherogenic dyslipidemia; and
computer program code for automatically generating a report of the risk assessment for each patient sample, the computer program code for generating the report including computer program code for;
(a) arranging each of the obtained lipoprotein subclass constituent values in a viewable format which positions the lipoprotein subclass constituent values as a quantified number adjacent to a corresponding risk analysis portion such that a respective risk analysis portion for each lipoprotein subclass constituent value is positioned in side by side alignment with the corresponding lipoprotein subclass constituent value to act as a contemporaneous guide, the risk analysis portion having a plurality of segments a respective one of which characterizes the quantified lipoprotein subclass constituent value'"'"'s determined risk level;
(b) displaying the NMR-measured subclass constituent risk result corresponding to the actual constituent value within the respective risk analysis portion such that the risk associated with the lipoprotein constituent value is readily apparent; and
(c) providing a metabolic abnormality or metabolic syndrome and/or atherogenic dyslipidemia summary identifying whether a clustering of abnormal measured lipoprotein subclass constituent values for selected different lipoprotein subclass constituents exists according to predetermined test criteria and indicating which of the plurality of the measured lipoprotein subclass constituent values are abnormal. - View Dependent Claims (38, 39, 40, 41, 42, 43)
providing at least three different result summary segments, a lipid profile segment and a lipoprotein-subclass profile segment, and a separate metabolic abnormality summary segment, wherein the lipid profile segment presents the results of the lipoprotein measurements for total cholesterol, LDL concentration cholesterol equivalent, HDL concentration cholesterol equivalent, and Triglycerides, wherein the subclass profile segment presents the results of the lipoprotein measurements for concentration and size of LDL particles, large HDL, and large VLDL, and wherein the metabolic abnormality summary segment presents the patient'"'"'s risk identification of a metabolic abnormality.
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40. A computer program product according to claim 37, wherein the computer program code further associates the lipoprotein constituent values for LDL particle concentration number, the level of large HDL, and the level of large VLDL triglyceride with a risk analysis portion which includes at least three discrete segments, and wherein the computer program code that generates the discrete segments identifies the respective measured lipoprotein constituent value as having a particular risk level associated therewith.
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41. A computer program product according to claim 37, further comprising computer program code for adjusting the predetermined risk criteria and corresponding levels of risk representing an increased risk and/or optimal or low risk level relative to the general population based upon the existence of or susceptibility to an identified high-risk medical condition in the patient.
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42. A computer program product according to claim 40, wherein the computer program code for generating the at least three discrete segments define a first desirable, negative, or low risk segment, a second borderline or intermediate risk segment, and a third positive, increased and/or high risk segment.
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43. A computer program product according to claim 40, wherein the computer program code for generating the discrete segments arranges and aligns the risk analysis portions to present the higher risk segments in a substantially vertically aligned manner, and wherein the computer program product further comprises computer program code for arranging the measured values for the lipoprotein constituents within respective boxes, each box disposed proximate to and laterally offset from its corresponding discrete segments of its respective risk analysis portion such that the measured values are arranged in vertical alignment proximate one side of the report and the risk analysis portions are arranged about the opposing side of the report.
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44. A computer program product for automatically generating personalized lipoprotein-based assessed risk of coronary heart disease information for a plurality of subjects, the computer program product comprising:
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a computer readable storage medium having computer readable program code embodied in said medium, said computer-readable program code comprising;
computer readable program code for generating NMR-based lipoprotein measurement values for a patient'"'"'s blood plasma or serum sample, the NMR-based lipoprotein measurement values comprising a plurality of lipoprotein constituent values including a constituent value for LDL particle concentration;
computer readable program code for comparing the LDL particle concentration with predetermined test criteria for determining whether the LDL particle concentration is elevated;
computer readable program code for comparing a plurality of NMR-based lipoprotein subclass constituent values to predetermined test criteria associated with abnormal lipoprotein values to determine if there is a clustering of abnormal values to determine the presence of a metabolic abnormality or atherogenic dyslipidemia; and
computer readable program code for assessing a patient'"'"'s risk of coronary heart disease based on the presence of at least one of an elevated LDL particleconcentration and/or the metabolic abnormality or atherogenic dyslipidemia, wherein the computer program code for assessing a patient'"'"'s risk of coronary heart disease includes computer program code that identifies the presence of both an elevated LDL particle concentration and the determination of an increased risk for having the metabolic abnormality, metabolic syndrome and/or atherogenic dyslipidemia, and wherein the computer program code for comparing a plurality of NMR-based lipoprotein subclass constituent values to predetermined test criteria associated with abnormal lipoprotein values to determine if there is a clustering of abnormal values for a plurality of different selected lipoprotein subclass constituents exists to determine the presence of a metabolic abnormality or atherogenic dyslipidemia lack a LDL particle concentration value.
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45. A computer program product for automatically generating personalized lipoprotein-based assessed risk of coronary heart disease information for a plurality of subjects, the computer program product comprising:
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a computer readable storage medium having computer readable program code embodied in said medium, said computer-readable program code comprising;
computer readable program code for generating NMR-based lipoprotein measurement values for a patient'"'"'s blood plasma or serum sample, the NMR-based lipoprotein measurement values comprising a plurality of lipoprotein constituent values including a constituent value for LDL particle concentration;
computer readable program code for comparing the LDL particle concentration with predetermined test criteria for determining whether the LDL particle concentration is elevated;
computer readable program code for comparing a plurality of NMR-based lipoprotein subclass constituent values to predetermined test criteria associated with abnormal lipoprotein values to determine if there is a clustering of abnormal values for a plurality of different selected lipoprotein subclass constituents to determine the presence of a metabolic abnormality or atherogenic dyslipidemia;
computer readable program code for assessing a patient'"'"'s risk of coronary heart disease based on the presence of at least one of an elevated LDL particle concentration and/or the metabolic abnormality or atherogenic dyslipidemia; and
computer program code for evaluating the lipoprotein measurement values and generating different values or ranges of values for the predetermined risk criteria that establishes the estimated risk level for at least one selected subclass constituent relative to the general population for a patient-specific treatment guideline based on the presence of predetermined risk criteria. - View Dependent Claims (46, 47, 48)
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49. A computer program product for automatically generating personalized lipoprotein-based assessed risk of coronary heart disease information for a plurality of subjects, the computer program product comprising:
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a computer readable storage medium having computer readable program code embodied in said medium, said computer-readable program code comprising;
computer readable program code for generating NMR-based lipoprotein measurement values for a patient'"'"'s blood plasma or serum sample, the NMR-based lipoprotein measurement values comprising a plurality of lipoprotein constituent values including a constituent value for LDL particle concentration;
computer readable program code for comparing the LDL particle concentration with predetermined test criteria for determining whether the LDL particle concentration is elevated;
computer readable program code for comparing a plurality of NMR-based lipoprotein subclass constituent values to predetermined test criteria associated with abnormal lipoprotein values to determine if there is a clustering of abnormal values associated with a plurality of different selected lipoprotein subclass constituents to determine the presence of a metabolic abnormality, metabolic syndrome, and/or atherogenic dyslipidemia;
computer readable program code for assessing a patient'"'"'s risk of coronary heart disease based on the presence of at least one of an elevated LDL particle concentration and/or the metabolic abnormality, syndrome and/or atherogenic dyslipidemia; and
computer program code for electronically generating the report and transmitting the report via email to a physician.
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Specification