Apparatus and method for determining tissue characteristics

• US 6,577,391 B1
• Filed: 03/24/2000
• Issued: 06/10/2003
• Est. Priority Date: 03/25/1999
• Status: Expired due to Term

• Current Assignee: Spectro Incorporated (Spectro Scientific, Inc.)
• Original Assignee: Spectro Incorporated (Spectro Scientific, Inc.)
• Inventors: Arche, Glenn S., Sanders, Walter R., Faupel, Mark L., Harrell, Tim, Bambot, Shabbir B., Farquhar, J. David, Kimbrell, Edward L.
• Primary Examiner(s): STAFIRA, MICHAEL PATRICK
• Application Number:
  US09/533,817
• Time in Patent Office: 1,173 Days
• Field of Search: 356/337, 356/39, 356/300, 356/301, 356/302, 600/309, 600/310, 600/317
• US Class Current: 356/337
• CPC Class Codes: A61B 2562/164 the sensor is mounted in or on a conformable substrate or carrier
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/0091 for mammography
• CPC Class Codes: A61B 5/4331 of the cervix A61B5/435 takes precedence
• CPC Class Codes: A61B 5/6843 Monitoring or controlling sensor contact pressure
• CPC Class Codes: G01N 21/21 Polarisation-affecting properties G01N21/19 takes precedence
• CPC Class Codes: G01N 21/474 Details of optical heads therefor, e.g. using optical fibres
• CPC Class Codes: G01N 21/49 within a body or fluid
• CPC Class Codes: G01N 21/64 Fluorescence; Phosphorescence

Abstract

An apparatus embodying the invention includes a probe head with an interrogation surface that is intended to be positioned adjacent or pushed into contact with a target material or tissue. The probe head is constructed to have a plurality of interrogation devices arranged across the face of the interrogation surface. The probe head is also constructed so that the interrogation device can conform to a non-uniform or non-planar surface of the target tissue. In some embodiments, the interrogation surface may have a particular shape that conforms to the shape of a target material. In other embodiments, one or more portions of the interrogation surface could be movable with respect to the remaining portions so that the interrogation surface could be movable with respect to remaining portions so that the interrogation surface can the thereby conform to a non-uniform surface. In still other embodiments, a plurality of separately moveable interrogation devices can be arranged across the interrogation surface. During a measurement process, the interrogation surface would be pressed into contact with the non-uniform surface to cause individual ones of the interrogation devices to move, thereby causing the probe head to conform to the non-uniform surface.

Claims

1. A method of detecting characteristics of a target material, comprising the steps of:

positioning a probe head having a plurality of interrogation devices adjacent a first plurality of interrogation positions on a non-uniform surface area of a target material so that the plurality of interrogation devices conform to the non-uniform surface area; and

detecting optical characteristics of the target material at the first plurality of interrogation positions with the plurality of interrogation devices, wherein a portion of the plurality of interrogation devices are positioned on a first probe face, wherein a portion of the plurality of interrogation devices are positioned on a second probe face, wherein the second probe face is axially slidable with respect to the first probe face, and wherein the positioning step comprises moving the second probe face relative to the first probe face so that the plurality of interrogation devices conform to the non-uniform surface area of the target material.

2. The method of claim 1, wherein optical characteristics of the target material are detected at the first plurality of interrogation positions with the plurality of interrogation through an optical system coupled to the interrogation devices.

3. The method of claim 1, wherein the target tissue comprises biological target tissue.

4. A method of detecting characteristics of a target tissue, comprising the steps of:

positioning a probe head having a plurality of interrogation devices adjacent a first plurality of interrogation positions on a non-uniform surface area of a target tissue so that the plurality of interrogation devices conform to the non-uniform surface area; and

detecting optical characteristics of the target tissue at the first plurality of interrogation positions with the plurality of interrogation devices, wherein a portion of the plurality of interrogation devices are positioned on a first probe face, wherein a portion of the plurality of interrogation devices are positioned on a second probe face, wherein the second probe face is axially slidable with respect to the first probe face, and wherein the positioning step comprises moving the second probe face relative to the first probe face so that the plurality of interrogation devices conform to the non-uniform surface area of the target tissue.