Apparatus for implementing hyperthermia

• US 6,579,496 B1
• Filed: 05/25/1999
• Issued: 06/17/2003
• Est. Priority Date: 05/25/1999
• Status: Expired due to Term

• Current Assignee: Thermasolutions
• Original Assignee: Viacirq Incorporated
• Inventors: Clupper, Marc, Rainier, Brad, Keeling, Glenn, Fausset, Michael
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): Bianco, Patricia
• Application Number:
  US09/318,420
• Time in Patent Office: 1,484 Days
• Field of Search: 604/4.01, 604/6.08, 604/6.09, 604/6.1, 604/6.11, 604/6.13, 604/6.16, 604/27-30, 604/5.01, 604/5.04, 604/6.01, 604/19, 604/65-67, 604/113-14, 604/122-23, 604/131, 604/151, 604/167.01, 604/167-3-1, 604/104-106, 601/3, 606/27, 422/44, 422/46, 422/82-2-, 422/105, 422/107-109, 422/113, 210/175-76, 210/85, 210/87, 210/634, 210/638, 210/739, 210/741-742, 210/767, 210/57, 210/90, 210/181, 210/252, 210/348, 210/416.1, 210/502.1, 607/104-106, 607/108-114, 417/15, 417/18, 417/20, 417/22, 165/200-201, 165/279-89, 165/287-88, 165/296
• US Class Current: 422/44
• CPC Class Codes: A61M 1/1664 with temperature control
• CPC Class Codes: A61M 1/28 Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
• CPC Class Codes: A61M 1/369 Temperature treatment
• CPC Class Codes: A61M 2205/18 with alarm
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 2205/366 by liquid heat exchangers
• CPC Class Codes: A61M 2205/50 with microprocessors or computers

Abstract

An apparatus and system for extracorporeal treatment utilizes a hemodialysis machine capable of heating dialysis fluid to 48° C., an optional parallel plate hemodialyzer together with a sorbent-based detoxifier, a tubular heat exchanger and a high flow pump—in addition to various probes and catheters—to effect extracorporeal treatment without adverse physiological effect and without the specific need for general anesthesia. The system inheres in the combined high flow of the pump-up to 2400 ml per minute—and the high temperature—52° C.—achievable in the heat exchanger, which together provide unprecedented speed and efficiency in the administration of hyperthemia treatments. The system is also a potentiating system in the administration of heat sensitive pharmaceutically active agents and is praticularly useful in the isolated anatomic areas of a patient.

Claims

1. An apparatus for implementing hyperthermia comprising:

at least one catheter for creating a fluid external to an animal or patient for which hyperthermia is indicated;

a pump in fluid communication with said at least one catheter, wherein said pump pumps fluid at approximately 2400 ml. per minute;

a heat exchanger through which said fluid circuit flows, said heat exchanger having a fluid reservoir for maintaining fluid in the reservoir at approximately 52°

C.;

at least one each of a pressure sensor, temperature sensor, and alarm; and

a computer and user interface means, adapted to receive signals from the pressure sensor and temperature sensor, for regulating a desured patient temperature, wherein said apparatus is capable of establishing the desired patient temperature in as little as twenty minutes.

2. The apparatus according to claim 1 wherein said alarm includes means for visual and audible detection when said alarm is activated.

3. The apparatus according to claim 2 wherein said heat exchanger is fluidly interconnected to both a heater and a cooler.

4. The apparatus according to claim 3 wherein said heater is a 1500 Wall heater and said cooler is a 1200 Watt cooler.

5. The apparatus according to claim 4 wherein said catheter is equipped with a bypass valve.

6. An apparatus for implementing hyperthermia in a subject comprising:

a first fluid circuit including;

a supply of a first fluid; and

a heater for heating a flow of the first fluid to an elevated temperature, wherein said heater establishes the elevated temperature of approximately 52°

C.;

a second fluid circuit including;

an inlet for a flow of a second fluid having a temperature which is lower than the elevate temperature of the first fluid, said inlet being adapted to be placed in fluid communication with the subject;

a pump for pumping the second fluid at a flow rate of substantially 2400 ml per minute; and

an outlet for the flow of the second fluid, said outlet being adapted to be placed in fluid communication with the subject;

a heat exchanger in fluid communication with each of the first and second fluid circuits for placing the flow of the first fluid in heat exchange relationship with the flow of the second fluid in order to raise the temperature of the second fluid for delivery to the subject; and

a control system for regulating the first and second fluid circuit in order to establish a desired treatment temperature for the patient.

7. The apparatus according to claim 6, wherein said control system includes a temperature sensor provided in the second fluid circuit downstream of the heat exchange.

8. The apparatus according to claim 7, wherein the control system includes a pressure sensor in the second fluid circuit downstream of said heat exchanger.

9. The apparatus according to claim 8, wherein the control system includes an air bubble detector in the second fluid circuit downstream of said heat exchange.

10. The apparatus according to claim 8, wherein said control system further includes an alarm for signaling at least one of an over-temperatures and over-pressure condition in the second fluid circuit.

11. The apparatus according to claim 6, wherein said heater constitutes a 1500 watt heater.

12. The apparatus according to claim 11, wherein said first fluid circuit further includes a cooler for the flow of the first fluid.

13. The apparatus according to claim 12, wherein said cooler is constituted by a 1200 watt cooler.

14. The apparatus according to claim 6, wherein the control system functions to regulate the temperature of the second fluid so as to not exceed 42°

C.

15. The apparatus according to claim 6, wherein said second fluid circuit further includes a bypass circuit having a valve for selectively interconnecting the inlet and outlet.

16. The apparatus according to claim 6, wherein said second fluid circuit further includes a hemodialyzer in fluid communication with the second fluid.

17. The apparatus according to claim 16, wherein the hemodialyzer is fluidly interposed between said pump and the heat exchanger.