Implantable blood glucose sensor system
First Claim
1. A subcutaneous-implant capsule for use in monitoring at least one of presence and activity of a specific chemical analyte, the subcutaneous-implant capsule comprising:
- an external wall defining an enclosure for subcutaneous implantation, said wall having at least a portion that is semi-permeable to said chemical analyte;
a macromolecular material contained within the enclosure, said material exhibiting physical change in response to contact with said chemical analyte;
a sensor also contained within the enclosure for providing a response to said physical change in the macromolecular material, and a transmitter for transmitting a signal from said sensor wherein the external wall of the enclosure totally encloses said sensor, said transmitter and the macromolecular material.
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Abstract
An implanted sensing device (1) for monitoring an analyte (e.g. blood-glucose) includes a non-toxic macromolecular material (2) encapsulated within an envelope (3) of bio-compatible semi-permeable membrane. A sensor (4) responds to change of a physical property (e.g. viscosity) of the material (2) when the analyte contacts the material (2), to signal the change to a measurement circuit (5) that together with the sensor (4) and a transponder (6) are included within the envelope (3). The transponder (6) is interrogated externally of the implanted sensor (1) by an interrogation unit (7) to transmit measurement data for processing and storage. The interrogation signal is utilized within the device (1) to power the circuit (5) and transponder (6) and conveys data to the device for re-calibration or resetting of signal-datum values to compensate for aging or drift.
531 Citations
19 Claims
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1. A subcutaneous-implant capsule for use in monitoring at least one of presence and activity of a specific chemical analyte, the subcutaneous-implant capsule comprising:
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an external wall defining an enclosure for subcutaneous implantation, said wall having at least a portion that is semi-permeable to said chemical analyte;
a macromolecular material contained within the enclosure, said material exhibiting physical change in response to contact with said chemical analyte;
a sensor also contained within the enclosure for providing a response to said physical change in the macromolecular material, and a transmitter for transmitting a signal from said sensor wherein the external wall of the enclosure totally encloses said sensor, said transmitter and the macromolecular material. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A sensing system for use in monitoring at least one of presence and activity of a specific chemical analyte, the sensing system comprising:
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a bio-compatible implant capsule and interrogating means that is operable for interrogating said capsule, said capsule defining a wall enclosure for bio-compatible implantation, said wall enclosure being at least partially semi-permeable to the specific chemical analyte, a macromolecular material contained within the enclosure, said macromolecular material exhibiting a physical change in response to contact with said specific chemical analyte, a sensor located within the enclosure to respond to said physical change, and a transmitter operable in response to interrogation of said capsule by said interrogating means, the transmitter transmitting to said interrogating means a signal dependent on the response of said sensor, and wherein said wall enclosure totally encloses said sensor, said transmitter and said material. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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15. A sensing device for use in monitoring at least one of presence and activity of a specific chemical analyte, the sensing apparatus comprising:
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an enclosure having a membrane-wall that is semipermeable to said chemical analyte, a macromolecular material contained within the enclosure, said macromolecular material exhibiting physical change in response to contact with said chemical analyte, a sensor contained within the enclosure, said sensor being responsive to said physical change exhibited by said macromolecular material to provide an electrical response to said change, and further means contained within the enclosure, said further means being connected within the enclosure to said sensor, and said further means comprising means for deriving a signal dependent on said electrical response of said sensor, and signal-transmitting means for transmitting said signal from within said enclosure to radiate from the sensing device. - View Dependent Claims (16)
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- 17. A sensing system for use in monitoring at least one of presence and activity of a specific chemical analyte, comprising a sensing device and interrogating means that is operable for interrogating said sensing device, said sensing device comprising an enclosure having a membrane-wall that is semi-permeable to said chemical analyte, macromolecular material contained within the enclosure, said material exhibiting physical change in response to contact with said chemical analyte, a sensor contained within the enclosure to respond to said physical change, and further means contained within the enclosure, said further means being connected within said enclosure to said sensor, and said further means being operative in response to interrogation of said sensing means by said interrogating means to transmit to said interrogation means a signal dependent on the response of said sensor to said physical change, said signal being transmitted to said interrogation means by radiation from within the sensing device.
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19. A sensing device for use in monitoring at least one of the presence and activity of a specific chemical analyte, the sensing device comprising:
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an enclosure having a membrane-wall that is semi-permeable to said chemical analyte;
a macromolecular material contained within the enclosure, said macromolecular material exhibiting physical change in response to contact with said chemical analyte;
a sensor contained within the enclosure to respond to said physical change of the macromolecular material in response to contact with said chemical analyte, and a transmitter dependent on the response of said sensor for transmitting a signal from said sensing device; and
wherein said macromolecular material comprises a material having a rheological parameter exhibiting a change thereof in response to contact with said chemical analyte, and said response of the sensor is dependent upon said change in said rheological parameter.
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Specification