Dual mode antimicrobial compositions
First Claim
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1. An article that resists microbial infection, the article having interior and exterior surfaces, the article comprising:
- a metallic silver layer on at least one of the surfaces of the article;
a polyether polyurethaneurea block copolymer layer; and
an effective amount of an antimicrobial agent incorporated into the polymer layer and being capable of diffusing from the polymer layer.
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Abstract
The present invention provides compositions which reduce the possibility of inducing microbial resistance. The compositions comprise a fast-acting antimicrobial agent and a long-lasting antimicrobial agent. The combined effect of the antimicrobial agents reduces microbial infection and resistance. Articles comprising the compositions of the present invention and methods for their manufacture are also provided.
319 Citations
34 Claims
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1. An article that resists microbial infection, the article having interior and exterior surfaces, the article comprising:
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a metallic silver layer on at least one of the surfaces of the article;
a polyether polyurethaneurea block copolymer layer; and
an effective amount of an antimicrobial agent incorporated into the polymer layer and being capable of diffusing from the polymer layer. - View Dependent Claims (2, 3, 4, 24, 25)
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5. A coated article comprising:
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an article having a plurality of surfaces; and
a coating covering at least part of the surfaces, wherein the coating comprises;
a silver layer deposited on at least part of one of the surfaces of the article; and
an outer layer, covering the silver layer, comprising a durable and lubricious polyether polyurethaneurea block copolymer and an effective amount of an antimicrobial agent and, wherein the antimicrobial agent is capable of diffusing from the outer layer. - View Dependent Claims (6, 7, 8, 9, 21, 22, 23, 26)
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10. A method for producing a microbe resistant article comprising:
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a) depositing a layer of metallic silver on a surface of the article;
b) preparing a coating solution capable of producing a coating by dissolving polymer or monomers which react to form polymer in solvent;
c) incorporating at least one antimicrobial agent into the coating solution; and
d) coating over the metallic silver layer with the coating solution containing the antimicrobial agent such that the antimicrobial agent is capable of diffusing from the coating, and where the polymer is a polyether polyurethaneurea block copolymer. - View Dependent Claims (11, 12, 13, 14, 27, 28, 31, 32)
cleaning the surface of the catheter;
activating the surface of the catheter;
forming the metallic silver layer on the article by dipping the article into a bath having a silver salt such that the silver salt is reduced to a metallic silver layer that is deposited on the surface of the catheter; and
stabilizing the metal silver layer.
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15. A coated article comprising:
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a first antimicrobial agent disposed on a surface of the article; and
a second antimicrobial agent disposed in a coating covering the first antimicrobial agent, wherein the first antimicrobial agent is a continuous surface-coated metallic silver that is capable of releasing silver ions and has a longer lasting antimicrobial activity than the second antimicrobial agent, and wherein the second antimicrobial agent is capable of diffusing from the coating more rapidly than the first antimicrobial agent. - View Dependent Claims (16, 17, 18, 19, 20, 30)
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29. An article comprising:
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a catheter having exterior and interior surfaces, the catheter being made of a polymer selected from a group consisting of;
latex and silicone;
a metallic silver layer deposited on at least one of the catheter surfaces, the layer having a thickness between about 2 angstroms and about 10 microns;
a polyether polyurethane-urea block copolymer coating disposed to cover the metallic silver layer; and
chlorhexidine, in an amount between about 1% to about 10% based on the dry weight of the block copolymer coating, releasably disposed within the block copolymer coating.
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33. An article having a plurality of surfaces and comprising:
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a coating including (1) a silver layer deposited on at least part of one of the surfaces of the article, (2) a hydrogel polymer layer covering the silver layer, and (3) an effective amount of an antimicrobial agent disposed within the hydrogel polymer layer and capable of diffusing therefrom.
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34. A method of producing a microbe resistant article, the method comprising:
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a) cleaning and activating a surface of the article;
b) forming a metallic silver layer on the activated surface by dipping the article into a bath having a silver salt that is reduced to form a metallic silver layer on the activated surface;
c) stabilizing the metallic silver layer; and
d) coating the metallic silver layer with a polymer solution comprising at least one antimicrobial agent such that the antimicrobial agent is capable of diffusing therefrom.
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Specification