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Blood analyte monitoring through subcutaneous measurement

  • US 6,579,690 B1
  • Filed: 07/24/2000
  • Issued: 06/17/2003
  • Est. Priority Date: 12/05/1997
  • Status: Expired due to Term
First Claim
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1. A process for determining glucose concentration in blood, comprising:

  • determining, from a sample of subcutaneous fluid, a subcutaneous glucose concentration, and from the subcutaneous glucose concentration, a glucose concentration in blood by calculation (i) based on a model accounting for mass transfer of the glucose from blood to a subcutaneous region and uptake of the glucose by subcutaneous tissue, and (ii) utilizing a regularization technique in the calculation, wherein the blood glucose concentration is determined from the subcutaneous glucose concentration using the relationship;



    S


    t
    =km

    A

    (B-S)
    -Vkr



    S
    Km+S

    embedded image

    where V is the volume of the sensor, S is the subcutaneous glucose concentration, B is the blood glucose concentration, A is the surface area of the region surrounding the sensor, km is a mass transfer coefficient, Km is a Michaelis-Menten constant, and kr

    is the reaction rate constant for uptake of glucose by the subcutaneous tissue.

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