Blood analyte monitoring through subcutaneous measurement
First Claim
1. A process for determining glucose concentration in blood, comprising:
- determining, from a sample of subcutaneous fluid, a subcutaneous glucose concentration, and from the subcutaneous glucose concentration, a glucose concentration in blood by calculation (i) based on a model accounting for mass transfer of the glucose from blood to a subcutaneous region and uptake of the glucose by subcutaneous tissue, and (ii) utilizing a regularization technique in the calculation, wherein the blood glucose concentration is determined from the subcutaneous glucose concentration using the relationship;
where V is the volume of the sensor, S is the subcutaneous glucose concentration, B is the blood glucose concentration, A is the surface area of the region surrounding the sensor, km is a mass transfer coefficient, Km is a Michaelis-Menten constant, and kr′
is the reaction rate constant for uptake of glucose by the subcutaneous tissue.
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Abstract
One embodiment of the invention is a method for obtaining an estimate of an analyte concentration in a first fluid. First, measurements of an analyte concentration in a second fluid are obtained using a sensing device. An analyte concentration estimate in the first fluid is determined from these measurements by minimizing the relation: f[b]=x2[b]+λΨ[b], where b is a vector representing analyte concentration in the first body fluid, X2[b] is a function representing a fit between the estimates and the measurements, λ is a weighting function, and Ψ[b] is a function indicating smoothness of the analyte concentration estimates in the first fluid. Another embodiment includes a sensing device for obtaining the measurements of an analyte concentration in the first fluid and a processor configured and arranged to determine the analyte concentration in the first body fluid according to this method. This method and device can be used, for example, to determine blood glucose concentration from measurements of the glucose concentration in subcutaneous tissue. These measurements may be made using in vitro or in vivo samples. In some instances, a subcutaneously implanted sensing device, such as electrochemical sensor, is used to make the measurements.
1701 Citations
15 Claims
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1. A process for determining glucose concentration in blood, comprising:
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determining, from a sample of subcutaneous fluid, a subcutaneous glucose concentration, and from the subcutaneous glucose concentration, a glucose concentration in blood by calculation (i) based on a model accounting for mass transfer of the glucose from blood to a subcutaneous region and uptake of the glucose by subcutaneous tissue, and (ii) utilizing a regularization technique in the calculation, wherein the blood glucose concentration is determined from the subcutaneous glucose concentration using the relationship;
where V is the volume of the sensor, S is the subcutaneous glucose concentration, B is the blood glucose concentration, A is the surface area of the region surrounding the sensor, km is a mass transfer coefficient, Km is a Michaelis-Menten constant, and kr′
is the reaction rate constant for uptake of glucose by the subcutaneous tissue.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A process for determining analyte concentration in a first body fluid, comprising:
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obtaining measurements of an analyte concentration in a second body fluid, different from the first body fluid; and
determining an analyte concentration estimate in the first fluid from the measurements by minimizing the relation;
- View Dependent Claims (10, 11, 12, 13, 14, 15)
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Specification