Method and system for stabilizing reflected light

• US 6,580,935 B1
• Filed: 04/28/2000
• Issued: 06/17/2003
• Est. Priority Date: 03/12/1999
• Status: Expired due to Term

• Current Assignee: Cirrex Systems, LLC
• Original Assignee: Cirrex Corp. (Cirrex Systems, LLC)
• Inventors: Wach, Michael L., Marple, Eric T.
• Primary Examiner(s): Winakur, Eric F.
• Assistant Examiner(s): KREMER, MATTHEW J
• Application Number:
  US09/560,590
• Time in Patent Office: 1,145 Days
• Field of Search: 600/309-310, 600/322-324, 600/336, 600/473, 600/476, 356/39-42, 356/300-303, 385/115, 385/121
• US Class Current: 600/310
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: G02B 6/02052 comprising optical elements other than gratings, e.g. filters comprising gratings G02B6/02057

Abstract

A light stabilizing interface operatively linked to a collection wave guides for combining and stabilizing reflected light into a substantially even spatial distribution of light energy with a substantially uniform light intensity. The stabilization and substantially even spatial distribution of reflected light can be accomplished by mixing and transmitting device in the form of a single optical fiber and optical junction wave guides in the form of optical fibers having a smaller diameter relative to the mixing and transmitting device. The stabilization and substantially even spatial distribution of reflected light also can be accomplished by a single, integral device that includes a collection wave guide matching section and a transition region. The transition region terminates in a shaped end region that is designed to substantially match the geometry of the input interface of the light processing unit. The method and system for stabilizing reflected light can also enhance the drug development process by providing real-time in-vivo chemical analysis of the interactions between drugs and living tissue.

Claims

1. A reflected light stabilizing system comprising:

a light source unit for generating light;

a plurality of optical feed wave guides operatively linked to said light source for propagating the light in a first direction;

a light management system operatively linked to said plurality of optical feed wave guides for accepting light in said first direction and outputting said light to a sample, said light management system further operative to collect light reflected from the sample;

a plurality of optical collection wave guides for collecting the reflected light from the light management system propagating in a second direction;

a light stabilizing interface operatively linked to said plurality of collection wave guides for combining and stabilizing the reflected light into a substantially even spatial distribution of light energy with a substantially uniform light intensity; and

a light processing unit operatively linked to said light stabilizing interface for processing the light energy.

2. The system of claim 1, further comprising a plurality of optical connection wave guides disposed between said light stabilizing interface and the light processing unit.

3. The system of claim 2, wherein the plurality of optical connection wave guides are arranged into a substantially linear array.

4. The system of claim 1, wherein said light stabilizing interface includes a shaped end which is operatively linked to said light processing unit.

5. The system of claim 4, wherein the shaped end of the light stabilizing interface has a polygonal shape.

6. The system of claim 5, wherein the shaped end of the light stabilizing interface is substantially rectilinear.

7. The system of claim 1, wherein the light processing unit is an instrument that disperses the light energy.

8. The system of claim 1, wherein the light processing unit includes a wavelength separator unit.

9. The system of claim 8, wherein the light processing unit is a spectrograph.

10. The system of claim 1, further comprising a filter disposed between said optical collection wave guides and said light stabilizing interface.

11. The system of claim 1, further comprising a filter disposed between the optical feed wave guides and said light stabilizing interface.

12. The system of claim 1, wherein the light stabilizing interface comprises a single optical wave guide.

13. The system of claim 12, wherein the single optical wave guide is an optical fiber having a first diameter and each feed wave guide has a second diameter, said first diameter is substantially larger than said second diameter.

14. The system of claim 12, wherein said single optical wave guide has a substantially cylindrical shape.

15. A method for creating a substantially even spatial distribution of reflected light energy, comprising the steps of:

generating light with a light source unit;

propagating the light through a plurality of optical feed wave guides to a light management system;

outputting light to a sample;

collecting reflected light with the light management system;

collecting the reflected light from the light management system with a plurality of optical collection wave guides;

feeding the collected reflected light from the optical collection wave guides into a light stabilizing interface;

stabilizing and combining the reflected light into a substantially even spatial distribution of light energy with a substantially uniform light intensity with the light stabilizing interface; and

feeding the distributed light energy from the light stabilizing interface into a light processing unit.

16. The method of claim 15, further comprising the step of feeding the distributed light energy from the light stabilizing interface into a plurality of optical wave guides operatively linked to the light processing unit.

17. The method of claim 16, further comprising the step of arranging the plurality of optical wave guides operatively linked to the light processing unit into a substantially linear array.

18. The method of claim 15, further comprising the step of feeding the distributed light energy from a shaped end of the light stabilizing interface into a light processing unit.

19. The method of claim 18, wherein the shaped end of the light stabilizing interface has a polygonal shape.

20. The method of claim 18, wherein the shaped end of the light stabilizing interface is substantially rectilinear.

21. The method of claim 15, wherein the light processing unit is an instrument that disperses the light energy.

22. The method of claim 15, wherein the light processing unit includes a wavelength separator unit.

23. The method of claim 22, wherein the light processing unit is a spectrograph.

24. The method of claim 15, further comprising the step of filtering one of the reflected light and distributed light energy.

25. The method of claim 15, wherein the light stabilizing interface comprises a single optical wave guide.

26. The method of claim 25, wherein the single optical wave guide is an optical fiber having a first diameter and each feed wave guide has a second diameter, said first diameter is substantially larger than said second diameter.