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Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients

  • US 6,581,599 B1
  • Filed: 11/24/1999
  • Issued: 06/24/2003
  • Est. Priority Date: 11/24/1999
  • Status: Expired due to Term
First Claim
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1. A method of delivering a non-constant concentration of nitric oxide to a spontaneously breathing patient via delivery means comprising the steps of:

  • detecting the onset of inspiration;

    determining an inspiration flow profile for an individual breath;

    supplying an oxygen-containing gas to the delivery means, the oxygen-containing gas having a flow profile determined based on the inspiration flow profile; and

    supplying an nitric oxide-containing gas to the delivery means, the nitric oxide-containing gas having a flow profile that is less than the oxygen-containing gas flow profile at the onset of inspiration, wherein the difference between the flow profile of the oxygen-containing gas and the flow profile of the nitric oxide-containing gas progressively increases throughout inspiration.

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