Powder filling systems, apparatus and methods

• US 6,581,650 B2
• Filed: 06/04/2001
• Issued: 06/24/2003
• Est. Priority Date: 04/26/1996
• Status: Expired due to Term

• Current Assignee: Novartis Pharma AG (Novartis Ag)
• Original Assignee: Nektar Therapeutics Incorporated
• Inventors: Rocchio, Michael J., Parks, Derrick J., Wightman, Dennis E., Naydo, Kyle, Smith, Adrian E.
• Primary Examiner(s): MAUST, TIMOTHY LEWIS
• Application Number:
  US09/873,771
• Publication Number:
  US 20010047837A1
• Time in Patent Office: 750 Days
• Field of Search: 141/18, 141/12, 141/2-8, 141/67-71, 141/115, 141/125, 141/129, 141/234, 141/237, 141/238, 141/241, 141/242, 141/280, 141/286, 141/83, 141/94, 141/95, 222/345, 222/346, 222/368, 222/636, 222/189.06, 209/311, 209/312, 209/315, 209/318, 209/380, 209/344, 209/352, 209/369, 128/203.15, 604/158
• US Class Current: 141/12
• CPC Class Codes: B65B 1/366 about a horizontal axis of symmetry
• CPC Class Codes: B65B 9/042 for fluent material

Abstract

The invention provides methods, systems and apparatus for the metered transport of fine powders into receptacles. According to one exemplary method, the fine powder is first fluidized. At least a portion of the fluidized fine powder is then captured. The captured fine powder is then transferred to a receptacle, with the transferred powder being sufficiently uncompacted so that it may be dispersed upon removal from the receptacle.

Claims

1. An apparatus for filling a receptacle with powder medicament, the apparatus comprising:

a supply of powder medicament;

a chamber; and

a screen between the supply of powder medicament and the chamber, the screen being translatable to fluidize the powder medicament;

wherein the apparatus is configured such that a vacuum may be applied to the chamber to assist in capturing powder and wherein pressure may be applied to the chamber to eject captured powder from the chamber and into a receptacle.

2. An apparatus according to claim 1 wherein the chamber is in a rotatable member that is rotatable between a powder capturing position and a powder ejecting position.

3. An apparatus according to claim 1 further comprising a controller capable of causing the vacuum or the pressure to be applied to the chamber.

4. An apparatus according to claim 1 wherein the screen is positioned so that powder medicament flows through one or more apertures in the screen.

5. An apparatus according to claim 1 wherein the screen is cyclically translatable.

6. An apparatus according to claim 5 wherein the screen is cyclically translatable in an oscillating pattern.

7. An apparatus according to claim 6 wherein the screen is adapted to be oscillated at a frequency of from about 1 Hz to 500 Hz.

8. An apparatus according to claim 1 wherein the screen is generally V-shaped.

9. An apparatus according to claim 1 wherein the screen is flat.

10. An apparatus according to claim 1 further comprising a second screen.

11. An apparatus according to claim 10 wherein one of the screens is generally V-shaped.

12. An apparatus according to claim 1 further comprising a funnel between the screen and the chamber, the funnel assisting in channeling fluidized powder into the chamber.

13. An apparatus according to claim 1 further comprising a trimming member to remove excess powder from the chamber.

14. An apparatus according to claim 1 further comprising a line in communication with the chamber, the line being connectble to a source of vacuum and to a source of pressure.

15. An apparatus according to claim 14 further comprising a controller capable of selectively connecting the line to the source of vacuum or to the source of pressure.

16. An apparatus according to claim 14 further comprising a filter between the chamber and the source of vacuum.

17. An apparatus according to claim 16 wherein the filter has apertures of about 0.8 micrometers or less.

18. A method of filling a receptacle with powder medicament, the method comprising:

providing a chamber and a screen above the chamber;

translating the screen to fluidize the powder medicament;

applying a vacuum to the chamber to assist in capturing the powder medicament in the chamber; and

applying pressure to the chamber to eject the powder medicament from the chamber and into a receptacle.

19. A method according to claim 18 further comprising moving the chamber before applying pressure to the chamber.

20. A method according to claim 18 wherein the receptacle comprises a blister package.

21. A method according to claim 18 wherein the powder medicament comprises fine particles having a mean size of less than about 10 μ

m.