Advanced sensor systems for biotelemetry

• US 6,582,365 B1
• Filed: 07/09/1999
• Issued: 06/24/2003
• Est. Priority Date: 07/09/1998
• Status: Expired due to Fees

• Current Assignee: Administrator of The National Aeronautics and Space Administration
• Original Assignee: United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration
• Inventors: Somps, Christopher J., Ricks, Robert D., Hines, John W., Mundt, Carsten W.
• Primary Examiner(s): Hindenburg, Max F.
• Assistant Examiner(s): ASTORINO, MICHAEL C
• Application Number:
  US09/350,736
• Time in Patent Office: 1,446 Days
• Field of Search: 600/300-301, 600/508, 600/549, 600/547, 600/304, 600/551, 128/903, 128/920, 607/32, 607/60, 607/22, 340/870-1-8, 340/500, 340/505, 455/100
• US Class Current: 600/300
• CPC Class Codes: A61B 5/0008 Temperature signals
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/02411 of foetuses
• CPC Class Codes: A61B 5/076 Permanent implantations telemetry using implanted circuitry A61B5/0031; implanted stimulators for therapy A61N1/3605, A61N1/362, A61N1/372
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/344 Foetal cardiography
• CPC Class Codes: Y10S 128/903 Radio telemetry

Abstract

The present invention relates to telemetry-based sensing systems that continuously measures physical, chemical and biological parameters. More specifically, these sensing systems comprise a small, modular, low-power implantable biotelemetry system capable of continuously sensing physiological characteristics using implantable transmitters, a receiver, and a data acquisition system to analyze and record the transmitted signal over several months. The preferred embodiment is a preterm labor and fetal monitoring system.

Key features of the invention include Pulse Interval Modulation (PIM) that is used to send temperature and pressure information out of the biological environment. The RF carrier frequency is 174-216 MHz and a pair of RF bursts (pulses) is transmitted at a frequency of about 1-2 Hz. The transmission range is 3 to 10 feet, depending on the position of the transmitter in the body and its biological environment. The entire transmitter is encapsulated in biocompatible silicone rubber. Power is supplied by on-board silver-oxide batteries. The average power consumption of the current design is less than 30 μW., which yields a lifetime of approximately 6-9 months. Chip-on-Board technology (COB) drastically reduces the size of the printed circuit board from 38×28 mm to 22×8 mm. Unpackaged dies are flip-chip bonded directly onto the printed circuit board, along with surface mount resistors and capacitors. The invention can monitor additional physiological parameters including, but not limited to, ECG, blood gases, glucose, and ions such as calcium, potassium, and sodium.

Claims

1. A telemetry system for measuring at least two physiological characteristics from a position implanted inside a living subject and transmitting the individual characteristics as physiological data to a remote location, the system comprising:

a transmitter for sensing and transmitting physiological data in a pulse interval modulated signal;

a receiver configured to receive and convert the pulse interval modulated signal into digital pulse stream, the receiver decoding the digital pulse stream into voltages proportional to the individual characteristics of the physiological data;

a data acquisition card configured to digitize the physiological data; and

a signal processing system for display and storage of the individual characteristics of the physiological data over time.

2. The telemetry system of claim 1 wherein the signal processing system includes a computer configured to perform multiple real-time analysis routines on a predetermined time period for one or more of the individualized characteristics of the physiological data.

3. The telemetry system of claim 2 wherein the signal processing system includes a computer configured to update the individualized characteristics of the physiological data at a predetermined rate and periodically generate a temporary spreadsheet array.

4. The telemetry system of claim 3 wherein the signal processing system includes a computer configured to save the physiological data after a predefined number of data samples have been collected in the temporary spreadsheet array.

5. The telemetry system of claim 2 wherein the subject is a fetus and the configuration of the computer signal processing system determines a baseline from the first physiological data samples, references the baseline at a defined level for detection of peaks, and correlates each peak to a contraction.

6. The telemetry system of claim 5 wherein the computer is further configured to accumulate all peaks over a predetermined time period and measure the times between successive peaks to determine periodicity.

7. The telemetry system of claim 6 wherein the computer charts said determined contraction periodicity.

8. The telemetry system of claim 5 wherein the computer is further configured to perform a fast Fourier transform on the physiological data and display the resulting spectrum.

9. The telemetry system of claim 5 wherein the computer is further configured to integrate and display the area between the signal and its baseline to characterize labor.

10. The telemetry system of claim 1 wherein the receiver comprises an integrator and sample-and-hold circuit to convert varying time intervals of the physiological data into DC voltage outputs.

11. The telemetry system of claim 1, wherein the transmitter includes a first sensor for a first physiological characteristic and a second sensor for a second physiological characteristic, and wherein said pulse interval modulated signal includes pairs of short pulses wherein the interval between the two pulses of a pair is proportional to a first physiological characteristic and the interval between successive pulse pairs is proportional to a second physiological characteristic.

12. A method of measuring at least two physiological characteristics from a device implanted in a position inside a living subject and transmitting the individual characteristics a physiological data to a remote application, the method comprising:

sensing and transmitting physiological data in a pulse Interval modulated signal to the remote location;

receiving and converting the pulse interval modulated signal into a digital pulse stream into voltages proportional to the individual characteristics of the physiological data;

digitizing the physiological data; and

displaying and storing of the individual characteristics of the physiological data over time.

13. The method of claim 12 wherein receiving and converting step includes converting the pulse internal modulated signal into a digital pulse stream and decoding the digital pulse stream into voltages proportional to the individual characteristics of the physiological data.

14. The method of claim 12 wherein the displaying and storing step includes performing multiple real-time analysis routines on a predetermined time period for one or more of the individualized characteristics of the physiological data.