Hybrid matrix implants and explants
First Claim
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1. An extracorporeal apparatus comprising:
- a composition comprising a body of matrix material comprising insoluble collagen fibrils, there being embedded within the body of matrix material (a) a plurality of cultured vertebrate cells and (b) a plurality of microspheres; and
a means for shunting blood from an animal to the composition and then back into a blood vessel of the animal.
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Abstract
An implantable device having a body of matrix material made up of insoluble collagen fibrils, and disposed therewithin
(a) a plurality of vertebrate cells; and
(b) a plurality of microspheres each of which consists primarily of one or more of the following materials: collagen, polystyrene, dextran, polyacrylamide, cellulose, calcium alginate, latex, polysulfone, or glass.
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Citations
20 Claims
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1. An extracorporeal apparatus comprising:
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a composition comprising a body of matrix material comprising insoluble collagen fibrils, there being embedded within the body of matrix material (a) a plurality of cultured vertebrate cells and (b) a plurality of microspheres; and
a means for shunting blood from an animal to the composition and then back into a blood vessel of the animal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
providing the extracorporeal apparatus of claim 2; - and
shunting a portion of the patient'"'"'s blood through the apparatus and back into the patient'"'"'s bloodstream, so that the polypeptide secreted by the cells mixes with the blood.
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Specification