Controller/detector interfaces for microfluidic systems

• US 6,582,576 B1
• Filed: 10/07/1999
• Issued: 06/24/2003
• Est. Priority Date: 08/29/1997
• Status: Expired due to Term

• Current Assignee: Caliper Holdings Incorporated
• Original Assignee: Caliper Holdings Incorporated
• Inventors: Chow, Calvin Y. H., Kennedy, Colin B., Parce, John Wallace, Bousse, Luc J., McReynolds, Richard J.
• Primary Examiner(s): Nguyen, Nam
• Assistant Examiner(s): STARSIAK, JOHN S
• Application Number:
  US09/413,766
• Time in Patent Office: 1,356 Days
• Field of Search: 204/450, 204/451, 204/452, 204/453, 204/454, 204/455, 204/600, 204/601, 204/602, 204/603, 204/604, 204/605
• US Class Current: 204/601
• CPC Class Codes: B01J 19/0093 Microreactors, e.g. miniaturised or microfabricated reactors laboratory containers with capillary fluid transport in microfabricated channels or chambers B01L3/5027
• CPC Class Codes: B01J 2219/00853 Employing electrode arrangements
• CPC Class Codes: B01L 2200/027 for microfluidic devices
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2400/0415 electrical forces, e.g. electrokinetic
• CPC Class Codes: B01L 3/502715 characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
• CPC Class Codes: B01L 9/527 for microfluidic devices, e.g. used for lab-on-a-chip
• CPC Class Codes: G01N 27/44743 Introducing samples
• CPC Class Codes: G01N 27/44791 Microapparatus sample containers with integrated microfluidic structures B01L3/5027
• CPC Class Codes: G01N 27/453 Cells therefor
• CPC Class Codes: Y10T 436/2575 Volumetric liquid transfer

Abstract

The present invention is generally directed to improved methods, structures and systems for interfacing microfluidic devices with ancillary systems that are used in conjunction with such devices. These systems typically include control and monitoring systems for controlling the performance of the processes carried out within the device, e.g., controlling internal fluid transport and direction, monitoring and controlling environmental conditions and monitoring results of the processes performed, e.g., detection.

Claims

1. A microfluidic device comprising:

a body structure having an interior portion;

a microscale channel network disposed in the interior portion of the body structure;

a plurality of ports disposed through a portion of the body structure in fluid communication with said microscale channel network; and

a plurality of electrical conduits independently coupling the plurality of ports with a plurality of electrical contact pads disposed on a first exterior surface of the body structure;

wherein at least one of said electrical conduits has a thickness less than 1500 Å and

comprises at least a first metal component made of titanium/tungsten alloy.

2. The microfluidic device of claim 1, wherein the first metal component is between about 50 Å

and about 600 Å

thick.

3. The microfluidic device of claim 1, wherein the first metal component is between about 300 Å

and about 500 Å

thick.

4. The microfluidic device of claim 1, wherein the first metal component made of titanium/tungsten alloy includes a platinum overlayer that does not substantially degrade under applied current densities greater than 0.1 mA/cm².

5. The microfluidic device of claim 1, wherein the first metal component made of titanium/tungsten alloy includes a platinum overlayer that does not substantially degrade under applied current densities greater than 1 mA/cm².

6. The microfluidic device of claim 1, wherein the first metal component made of titanium/tungsten alloy includes a platinum overlayer that does not substantially degrade at a temperature between about 500 °

C. and about 1400 °

C.

7. A microfluidic device comprising:

a body structure having an interior portion;

a microscale channel network disposed in the interior portion of the body structure;

a plurality of ports disposed through a portion of the body structure in fluid communication with said microscale channel network; and

a plurality of electrical conduits independently coupling the plurality of ports with a plurality of electrical contact pads disposed on a first exterior surface of the body structure; and

wherein at least one of said electrical conduits has a thickness less than 1500 Å and

comprises at least a first metal component and a platinum conductive layer overlaying the first metal component, and wherein the first metal component is selected from the group of tungsten, palladium, ruthenium, iridium, osmium and rhodium.

8. The microfluidic device of claim 7, wherein the platinum conductive layer is between about 400 Å

and about 1200Å

thick.

9. The microfluidic device of claim 7, wherein the platinum conductive layer is between about 700 Å

and about 1100 Å

thick.

10. A microfluidic device comprising:

a body structure having an interior portion;

a microscale channel network disposed in the interior portion of the body structure;

a plurality of ports disposed through a portion of the body structure in fluid communication with said microscale channel network; and

a plurality of electrical conduits independently coupling the plurality of ports with a plurality of electrical contact pads disposed on a first exterior surface of the body structure; and

wherein at least one of said electrical conduits has a thickness less than 1500 Å and

comprises at least a first metal component made of titanium/tungsten alloy with a platinum overlayer that does not substantially degrade under applied current densities greater than 10 mA/cm².