Method for treating wounds, promoting healing and avoiding amputations in diabetic and non-diabetic patients

• US 6,582,716 B2
• Filed: 06/15/2001
• Issued: 06/24/2003
• Est. Priority Date: 06/16/2000
• Status: Expired due to Term

• Current Assignee: Thomas T. Aoki
• Original Assignee: Thomas T. Aoki
• Inventors: Aoki, Thomas T.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Bennett, Rachel M.
• Application Number:
  US09/881,835
• Publication Number:
  US 20010053382A1
• Time in Patent Office: 739 Days
• Field of Search: 424/422, 424/423, 424/400, 514/3, 514/4
• US Class Current: 424/422
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61K 38/28 Insulins

Abstract

The present invention is a system and method capable of increasing glucose oxidation in an affected area and therefore providing more energy for treating wounds, promoting healing and avoiding amputations in both diabetic and non-diabetic patients. The current invention is the treating of wounds, promoting healing and avoiding lower extremity amputations using insulin pulses to a patient utilizing Chronic Intermittent Intravenous Insulin Therapy to achieve an increase in glucose oxidation in tissues surrounding an affected area, therefore treating wounds, promoting healing and avoiding amputations in both diabetic and non-diabetic patients.

Claims

1. A method for treating wounds, promoting healing and avoiding amputations in diabetic and non-diabetic patients by improving the dietary fuel capabilities and correct an overutilization of free fatty acids thereby enhancing available energy in tissue surrounding an affected area comprising the steps of:

a) determining a steady baseline respiratory quotient of a patient and obtaining a subsequent respiratory quotient every 30 minutes, the steady baseline respiratory quotient being two identical consecutive respiratory quotients less than 0.90 measured five minutes apart,

b) having the patient consume a liquid or food containing 60 to 100 grams of glucose,

c) administering a pulse of insulin through an intravenous site at a six minute interval of time until the subsequent respiratory quotient shows an improvement over the steady baseline respiratory quotient, the pulse of insulin being 20 to 35 milliunits of insulin per kilogram of body weight for a non-diabetic and a Type I diabetic, the pulse of insulin being 70-200 milliunits of insulin per kilogram of body weight for a Type II diabetic, the improvement over the steady baseline respiratory quotient being a respiratory quotient of 0.90 or greater, the subsequent respiratory quotient improvement over the steady baseline respiratory quotient being a measurement of increased glucose oxidation by tissue surrounding the affected area;

d) allowing the patient to rest one hour, and

e) repeating the steps a-d at least three times.

2. The method of claim 1, wherein the intravenous site further comprises a needle or catheter located in the patient'"'"'s body, hand or forearm.

3. The method of claim 1, wherein the pulse of insulin is administered by an intravenous infusion device.

4. The method of claim 1, wherein the intravenous site is converted to a heparin or a saline lock during step (d).

5. The method of claim 1, wherein said steps a-e are repeated at least once a week.

6. The method of claim 5, wherein said steps a-e are repeated three or more times a week.