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Method and apparatus for rapid measurement of HbA1c

  • US 6,582,964 B1
  • Filed: 01/23/2002
  • Issued: 06/24/2003
  • Est. Priority Date: 05/12/1999
  • Status: Expired due to Term
First Claim
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1. A method of determining a diabetic patient'"'"'s compliance with their insulin dosing regime comprising:

  • (i) obtaining an untreated blood specimen from said patient;

    (ii) measuring with a spectrophotometer, absorbance of radiation by each of HbA1c and total Hb in said specimen, the radiation being directed into said specimen in a direction that is substantially parallel to the direction in which red blood cells in said specimen fall under the effect of gravity;

    (iii) using a calibration algorithm for each of said HbA1c and total Hb to calculate a concentration of each of said HbA1c and total Hb in said specimen from said absorbances measured in step (ii); and

    (iv) determining a ratio between the concentrations of HbA1c and total Hb, wherein an elevated concentration ratio of HbA1c to total Hb reflects a lack of patient compliance.

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