Oxidant scavengers
First Claim
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1. A method of treating a pathological condition of a patient resulting from degradation of NO·
- or a biologically active form thereof comprising administering to said patient an effective amount of a compound having the activity of a catalytic antioxidant under conditions such that said treatment is effected.
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Abstract
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
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Citations
6 Claims
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1. A method of treating a pathological condition of a patient resulting from degradation of NO·
- or a biologically active form thereof comprising administering to said patient an effective amount of a compound having the activity of a catalytic antioxidant under conditions such that said treatment is effected.
- View Dependent Claims (2, 4)
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3. A method of treating a pathological condition of a patient resulting from peroxynitrite accumulation comprising administering to said patient an effective amount of a compound having the activity of a catalytic antioxidant under conditions such that said treatment is effected.
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5. A method of modulating NO·
- function as a neurotransmitter in a mammal comprising contacting said mammal with an amount of an oxidant scavenger of the formula,
or a pharmaceutically acceptable salt thereof wherein; R1 is a bond, wherein X is a halogen and Y is an alkyl group and wherein indicates bonding to R2 at any position and indicates bonding to R2 and the substituent at any position; and R2 is a bond, —
(CY′
2)n−
, —
(CY′
2—
CY′
=CY′
)n−
, —
(CY′
2—
Y′
2—
CH=CH)n−
, —
(CY′
=CY′
)n−
, orwherein Y′
is hydrogen or an alkyl group and wherein n is 1 to 8; andR3 is —
Y″
, —
OH, —
NH2, —
N−
(Y″
)3, —
COOH, —
COO−
, —
SO3H, —
SO3−
, —
C—
PO3H2 or —
C—
POO3H−
, where Y″
is an alkyl group, optionally complexed with a metal selected from the group consisting of manganese, copper and iron, sufficient to effect said modulation.
- function as a neurotransmitter in a mammal comprising contacting said mammal with an amount of an oxidant scavenger of the formula,
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6. A method of modulating NO·
- function as a neurotransmitter in a mammal comprising contacting said mammal with an amount of an oxidant scavenger of the formula,
or a pharmaceutically acceptable salt thereof, or metal complex thereof wherein said metal is selected from the group consisting of manganese, copper and iron, wherein; each R1′
is independently a bond,wherein Y″
is an alkyl group, and whereinindicates bonding to R3′
at any position andindicates bonding to R2′ and
the R1′
phenyl substituent at any position;each R2′
is independently a bond, or —
(CH2 )n—
wherein n is 1-4,each R3′
is independently —
Y″
, —
Y′
″
, —
H, —
OH, —
OY″
, —
NO2, —
CN, —
NH2, —
COOH, —
COY″
, —
COO−
, or a heterocyclic group wherein Y″
is as defined above and Y′
″
is a primary, secondary, tertiary or quaternary amine,wherein when R1′
isR3′
is not COOH, COY″
or COO−
,wherein when R1′
isR3′
is not —
NO2, andwherein —
R1′
—
R2′
—
R3′
, collectively, are not —
H, sufficient to effect said modulation.
- function as a neurotransmitter in a mammal comprising contacting said mammal with an amount of an oxidant scavenger of the formula,
Specification