Human protease inhibitor and polynucleotides encoding the same

• US 6,583,269 B1
• Filed: 12/18/2001
• Issued: 06/24/2003
• Est. Priority Date: 12/18/2000
• Status: Expired due to Fees

• Current Assignee: Lexicon Genetics, Incorporated
• Original Assignee: Lexicon Genetics, Incorporated
• Inventors: Hu, Yi, Walke, D. Wade, Nepomnichy, Boris
• Primary Examiner(s): Prouty, Rebecca E.
• Assistant Examiner(s): Walicka, Malgorzata A.
• Application Number:
  US10/024,427
• Time in Patent Office: 553 Days
• Field of Search: 536/23.2, 536/24.33, 536/23.5, 435/69.2, 435/320.1, 435/252.3, 435/325, 530/350
• US Class Current: 530/350
• CPC Class Codes: A61K 48/00 Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• CPC Class Codes: C07K 14/47 from mammals
• CPC Class Codes: C07K 14/8107 Endopeptidase (E.C. 3.4.21-99) inhibitors
• CPC Class Codes: C07K 14/8121 Serpins

Abstract

Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.

Claims

1. An isolated cDNA molecule comprising at least 80 contiguous bases of nucleotide sequence of the serpin encoding sequence described in SEQ ID NO:

1.

2. An isolated cDNA molecule comprising a nucleotide sequence that:

(a) encodes the amino acid sequence shown in SEQ ID NO;

2; and

(b) hybridizes under stringent conditions with wash conditions of 0.1×

SSC/0.1% SDS at 68°

C. to the nucleotide sequence of SEQ ID NO;

1 or the complement thereof.

3. An isolated recombinant expression vector comprising a nucleotide sequence encoding the amino acid sequence shown in SEQ ID NO:

2.

4. An isolated protein comprising the amino acid sequence shown in SEQ ID NO:

2.

5. An isolated cDNA molecule comprising the nucleotide sequence of SEQ ID NO:

1.