Multiple local probe measuring device and method

• US 6,583,411 B1
• Filed: 09/13/2000
• Issued: 06/24/2003
• Est. Priority Date: 09/13/2000
• Status: Expired due to Term

• Current Assignee: European Molecular Biology Laboratory
• Original Assignee: European Molecular Biology Laboratory
• Inventors: Hörber, Johann Karl Heinrich, Altmann, Stephan Maximilian
• Primary Examiner(s): Lee, John R.
• Assistant Examiner(s): Vanore, David A.
• Application Number:
  US09/660,885
• Time in Patent Office: 1,014 Days
• Field of Search: 250/306, 250/307, 250/310, 250/311, 250/309
• US Class Current: 850/4
• CPC Class Codes: G01Q 40/00 Calibration, e.g. of probes
• CPC Class Codes: G01Q 70/06 Probe tip arrays
• CPC Class Codes: Y10S 977/874 Probe tip array

Abstract

The invention provides a local probe measuring device for effecting local measurements refering to a sample, comprising a plurality of local probes for local measurements with respect to a sample or a reference surface, a measurement condition adjustment arrangement adapted to commonly adjust measurement conditions of said local probes with respect to the sample or the reference surface, a plurality of detection arrangements, each being associated or adapted to be associated to one particular of said local probes and adapted to independently detect measurement data refering to local measurements effected by said particular local probe. Further, methods for effecting local measurements and local manipulations by means of multiple local probes are provided.

Claims

1. A local probe measuring device for effecting local measurements referring to a sample, the device comprising:

a plurality of local probes for local measurements with respect to a sample or a reference surface;

a rigid mechanical coupling between said local probes;

a position adjusting means for commonly adjusting distance and lateral position relations of said local probes with respect to the sample or the reference surface;

a plurality of detection means, each being associated to a particular one of said local probes to independently detect measurement data from local measurements effected by said particular local probe; and

a controller that controls or stabilizes via said position adjusting means said distance and lateral position relations on the basis of certain measurement data which refer to local measurements effected by at least one of said local probes and which reflect said distance relations.

2. The device according to claim 1, wherein said controller controls or stabilizes via said position adjusting means a distance relation and a lateral positioning relation of at least one of said local probes on the basis of local measurements effected by at least one other local probe.

3. A local probe measuring device for measuring local interactions between a local probe arrangement and a sample, the device comprising:

a plurality of local probes adapted to interact locally with a sample or a reference surface;

a rigid mechanical coupling between the local probes;

a position adjusting means for commonly adjusting for all of said local probes at least one of a distance of the respective local probe with respect to the sample or the reference surface, and a local interaction of the respective local probe with the sample or the reference surfaces, and for commonly adjusting for all of said local probes at least one of a first lateral coordinate of the respective local probe with respect to the sample or the reference surface, and a second lateral coordinate of the respective local probe with respect to the sample or the reference surface; and

a plurality of detection arrangements, each being associated to a particular one of said local probes and each independently detects a local interaction of said particular local probe with the sample or the reference surface; and

a controller that controls or stabilizes via said position adjusting means for at least one of said local probes at least one of said distance and said local interaction on the basis of detection results obtained for at least one of said local probes via the respective detection arrangement, and said controller controls or stabilizes via said position adjusting means for at least one of said local probes at least one of said first lateral coordinate and said second lateral coordinate on the basis of detection results obtained for at least one of said local probes via the respective detection arrangement.

4. The device according to claim 3, wherein said controller controls or stabilizes via said position adjusting means for at least one of said local probes at least one of said distance and said local interaction on basis of detection results obtained for at least one other of said local probes via the respective detection arrangement.

5. The device according to claim 3, wherein said controller controls or stabilizes via said position adjusting means for at least one of said local probes at least one of said distance, said first lateral coordinate, said second lateral coordinate and said local interaction on basis of detection results obtained for at least one other of said local probes via the respective detection arrangement.

6. The device according to claim 5, wherein said controller controls or stabilizes via said position adjusting means for at least one of said local probes said distance and at least one of said first lateral coordinate and said second lateral coordinate of basis of detection results obtained for at least one other of said local probes via the respective detection arrangement.

7. The device according to claim 5, wherein said controller controls or stabilizes via said position adjusting means for said at least one of said local probes said distance, said first lateral coordinate and said second lateral coordinate on basis of detection results obtained for at least one other of said local probes via the respective detection arrangement.

8. The device according to claim 3, wherein under local interaction conditions with the sample or the reference surface at least one of said local probe and the respective detection arrangement associated therewith are sensitive to at least one of a change of its distance, a change of its first lateral coordinate and a change of its second lateral coordinate with respect to the sample or the reference surface.

9. The device according to claim 8, wherein at least one local probe and the respective detection arrangement associated therewith are sensitive substantially only to a change of the distance of said local probe with respect to the sample or the reference surface or have a substantially higher sensitivity to a change of the distance of said local probe with respect to the sample or the reference surface than to a change of one or both of said lateral coordinates with respect to the sample or the reference surface.

10. The device according to claim 8, wherein at least one local probe and the respective detection arrangement associated therewith are sensitive substantially only to a change of the first lateral coordinate of said local probe with respect to the sample or the reference surface or have a substantially higher sensitivity to a change of the first lateral coordinate of said local probe with respect to the sample or the reference surface than to a change of one or both of said distance and said second lateral coordinate with respect to the sample or the reference surface.

11. The device according to claim 8, wherein at least one local probe and the respective detection arrangement associated therewith are substantially sensitive only to a change of the second lateral coordinate of said local probe with respect to the sample or the reference surface or have a substantially higher sensitivity to a change of the second lateral coordinate of said local probe with respect to the sample or the reference surface than to a change of one or both of said distance and said first lateral coordinate with respect to the sample or the reference surface.

12. The device according to claim 8, wherein at least one local probe and the respective detection arrangement associated therewith are substantially sensitive only to a change of the distance and the first lateral coordinate of said local probe with respect to the sample or the reference surface or have a substantially higher sensitivity to a change of the distance and the first lateral coordinate of said local probe with respect to the sample or the reference surface than to a change of said second lateral coordinate with respect to the sample or the reference surface.

13. The device according to claim 8, wherein at least one local probe and the respective detection arrangement associated therewith are sensitive substantially only to a change of the distance and the second lateral coordinate of said local probe with respect to the sample or the reference surface or have a substantially higher sensitivity to a change of the distance and the second lateral coordinate of said local probe with to the sample or the reference surface than to a change of said first lateral coordinate with respect to the sample or the reference surface.

14. The device according to claim 8, wherein at least one local probe and the respective detection arrangement associated therewith are substantially sensitive to a change of the first lateral coordinate and the second lateral coordinate of said local probe with respect to the sample or the reference surface.

15. A local probe measuring device for measuring local interactions between a cantilever probe arrangement and a sample, comprising:

a plurality of cantilever probes that interact locally with a sample or a reference surface;

a rigid mechanical coupling between respective base sections of said cantilever probes;

a position adjusting means for commonly adjusting for all of said cantilever probes;

a distance of the base section of the respective cantilever probe with respect to the sample or the reference surface,

a first lateral coordinate of the base section of the respective cantilever probe with respect to the sample or the reference surface, and

a second lateral coordinate of the base section of the respective cantilever probe with respect to the sample or the reference surface, said first and second lateral coordinates defining the lateral position of the base section of the cantilever probe with respect to the sample or the reference surface;

a plurality of detection arrangements, each being associated to a particular one of said cantilever probes and each independently detects at least one of a deflection of said particular cantilever probe, a torsion of said particular cantilever probe and a local interaction of said particular cantilever probe with said sample or reference surface; and

a controller that controls or stabilizes via said position adjusting means for at least one of said cantilever probes at least one of said first and second lateral coordinates on the basis of detection results -obtained for at least one of said cantilever probes via the respective detection arrangement.

16. The device according to claim 15, wherein said controller controls or stabilizes via said positioning arrangement for at least one of said cantilever probes at least one of said distance, said first lateral coordinate, said second lateral coordinate and said local interaction on basis of detection results obtained for at least one other of said cantilever probes via the respective detection arrangement.

17. The device according to claim 15, wherein said controller controls or stabilizes via said position adjusting means for at least one of said cantilever probes said distance and at least one of said first lateral coordinate and said second lateral coordinate on basis of detection results obtained for at least one other of said cantilever probes via the respective detection arrangement.

18. The device according to claim 15, wherein said controller controls or stabilizes via said position adjusting means for at least one of said cantilever probes said distance, said first lateral coordinate and said second lateral coordinate on basis of detection results obtained for at least one other of said cantilever probes via the respective detection arrangement.

19. The device according to claim 15, wherein at least one of said cantilever probes is a triangular cantilever probe and wherein the particular detection arrangement provided measures a deflection of said triangular cantilever probe.

20. The device according to claim 15, wherein at least one of said cantilever probes is a beam-shaped cantilever probe and wherein in the particular detection arrangement provided measures at least one of a deflection and a torsion of said beam-shaped cantilever probe.

21. The device according to claim 20, wherein said detection arrangement measures a torsion of said beam-shaped cantilever probe.

22. The device according to claim 20, wherein said detection arrangement measures both a deflection and a torsion of said beam-shaped cantilever probe substantially independently of each other.

23. The device according to claim 15, wherein a first beam-shaped cantilever probe and a second beam-shaped cantilever probe of said cantilever probes extend at an angle of about 90 degrees with respect to each other and that a first and a second detection arrangement are provided, the first detection arrangement measures at least a torsion of the first beam-shaped cantilever probe and the second detection arrangement measures at least a torsion of the second beam-shaped cantilever probe.

24. The device according to claim 23, wherein said detection arrangements additionally measure a deflection of the respective beam-shaped cantilever probes substantially independently of the torsion of said beam-shaped cantilever probe.

25. The device according to claim 15, wherein a first of said cantilever probes is a cantilever probe, which is substantially softer with respect to torsion and bending as a second of said cantilever probes, and wherein a first and a second detection arrangement are provided, the first detection arrangement independently measures a torsion and a deflection of the first cantilever probe and the second detection arrangement measures at least a deflection of the second cantilever probe.

26. The device according to claim 25, wherein said second cantilever probe is a triangular cantilever probe.

27. The device according to claim 15, wherein said detection arrangements are based on at least one of an optical detection, a thermal detection, a capacitive detection, a piezo-electric detection and a detection of electronic tunneling.

28. The device according to claim 27, wherein at least one of said detection arrangements comprises an optical detection arrangement.

29. The device according to claim 27, characterized in that at least one of said detection arrangements comprises a position sensitive detector that receives a laser beam reflected by a tip portion of the respective cantilever probe.

30. The device according to claim 29, characterized in that the laser beam directed to the tip portion of one of the cantilever probes and the resulting reflected laser beam substantially extend in a longitudinal direction of the respective cantilever probe, if seen in a projection on a surface of said sample or on said reference surface or in a projection on a support surface for supporting said sample.

31. The device according to claim 29, wherein the laser beam directed to the tip portion of one of the cantilever probes and the resulting reflected laser beam substantially extend in a direction orthogonal to the longitudinal direction of the respective cantilever probe, if seen in a projection on a surface of said sample or on said reference surface or in a projection on a support surface for supporting said sample.

32. The device according to claim 29, wherein for at least one of said cantilever probes the respective position sensitive detector resolves an incidence position of the reflected laser beam on the detector only within one dimension.

33. The device according to claim 29, wherein for at least one of said cantilever probes the respective position sensitive detector resolves an incidence position of the reflected laser beam on the detector within two dimensions.

34. A method of effecting local measurements referring to a sample, the method comprising:

providing at least two local probes in a positional relation with respect to a sample or a reference surface;

adjusting a distance relation and a lateral positioning relation of the respective local probe for at least one of said local probes with respect to the sample or the reference surface, on the basis of measurements effected with respect to at least one other of said local probes; and

effecting a measurement with respect said at least one local probe with reference to said measurements effected with respect to said at least one other local probe.

35. The method according to claim 34, wherein said lateral positioning relation is adjusted with respect to only one lateral coordinate on the basis of measurements effected with respect to at least one other of said local probes.

36. The method according to claim 34, wherein said lateral positioning relation is adjusted with respect to two lateral coordinates on the basis of measurements effected with respect to at least one other of said local probes, wherein said two lateral coordinates define the lateral position of the local probe with respect to the sample or reference surface.

37. A method of effecting local manipulations referring to a sample, the method comprising:

providing at least two local probes in a positional relation with respect to a sample or a reference surface;

adjusting a distance relation and a lateral positioning relation of the respective local probe with respect to the sample or the reference surface, said distance relation and said lateral positioning relation being adjusted on the basis of measurements effected with respect to at least one other of said local probes; and

manipulating said sample by means of said at least one local probe with reference to said measurements effected with respect to said at least one other local probe.

38. The method according to claim 37, wherein said lateral positioning relation is adjusted with respect to only one lateral coordinate on the basis of measurements effected with respect to at least one other of said local probes.

39. The method according to claim 37, wherein said lateral positioning relation is adjusted with respect to two lateral coordinates on the basis of measurements effected with respect to at least one other of said local probes, and wherein said two lateral coordinates define the lateral position of the local probe with respect to the sample or reference surface.