Method for standardizing the MR image intensity scale

• US 6,584,216 B1
• Filed: 11/23/1999
• Issued: 06/24/2003
• Est. Priority Date: 11/23/1999
• Status: Expired due to Term

• Current Assignee: Pennsylvania University of The Trustees of The
• Original Assignee: Trustees Of The University Of Pennsylvania (University of Pennsylvania)
• Inventors: Udupa, Jayaram K., Nyúl, László G.
• Primary Examiner(s): Patel, Jayanti K.
• Assistant Examiner(s): Choobin, Barry
• Application Number:
  US09/447,781
• Time in Patent Office: 1,309 Days
• Field of Search: 382/131, 382/128, 382/168, 250/474.1, 600/407, 128/922, 378/21
• US Class Current: 382/131
• CPC Class Codes: G06T 2207/10088 Magnetic resonance imaging [MRI]
• CPC Class Codes: G06T 2207/20101 Interactive definition of point of interest, landmark or seed
• CPC Class Codes: G06T 2207/30004 Biomedical image processing
• CPC Class Codes: G06T 5/40 using histogram techniques
• CPC Class Codes: G06T 5/92 based on global image properties

Abstract

The present invention provides a method for standardizing MR image intensity scales by the use of post-processing intensity transformation techniques applied to routinely acquired images. The method requires neither specialized acquisition protocols, nor calibration phantoms. The standardizing method offers previously unattainable consistency of intensity meaning of tissues by devising a transformation that is specific to a given MRI protocol and/or for any body region to provide standardized images. Essentially, the histogram of a given volume image is deformed to match a “standard” histogram for the corresponding MRI protocol and body-region, thereby minimizing or eliminating the human interaction required in the per-case manual window adjustments needed to visualize MR images at physician viewing stations. The method offers significantly more consistent tissue meaning for MR image intensities than the images before standardization. Also provided are MR images having standardized intensity scales.

Claims

1. A method for standardizing MR image intensity scales for imaging a region of the body of a patient, wherein the method comprises post-processing intensity transforming an MR image acquired by an MRI protocol, wherein a standardized intensity histogram is achieved for the MRI protocol, and for the region of the patient'"'"'s body, comprising:

a) estimating for the MRI protocol and region of the patient'"'"'s body, certain landmarks from a given set of image histograms to form a standard scale histogram (a standardizer),

b) imaging the region of the patient'"'"'s body by the MRI protocol to form an image histogram, and

c) computing the standardized intensity histogram by mapping landmarks determined from the image histogram to corresponding landmarks of the standard scale histogram.

2. The method of claim 1, wherein standardization images of similar intensities have similar tissue meaning, independent of variations within or between MRI scanners.

3. The method of claim 1, wherein standardized images of similar intensities have similar tissue meaning, independent of variations within or between MRI scanners.

4. The method of claim 1, wherein standardization is specific to the MRI protocol.

5. The method of claim 1, wherein standardization is specific to the body region.

6. The method of claim 1, wherein standardization is specific to the specific MRI protocol and the specific body region.

7. The method according to claim 1, wherein the method is automated.

8. The method according to claim 1, wherein a standardizer τ

_Vi is stored in a lookup table.

9. The method according to claim 1, wherein a standardized image _si is stored as an output image.

10. The method according to claim 1, wherein standardization of the image permits using predetermined display window settings and facilitates image segmentation.

11. The method according to claim 8, wherein the images are accompanied by the standardizer lookup table when downloaded to a viewing station.

12. The method according to claim 8, wherein the images are automatically standardized.

13. The method according to claim 12, wherein standardization is built into an MR scanner, permitting production of real time images with the standard scale.

14. The standardized MR image intensity scales for imaging a region of the body of a patient according to claim 1.

15. The standardized MR image of a region of the body of a patient obtained by the method according to claim 1.

16. The standardized MR image of a region of the body of a patient obtained by the automated method according to claim 12.

17. The standardized MR image of a region of the body of a patient obtained by the method according to claim 13.